DegronMD

Uniprot ID: O15021

Source protein: Microtubule-associated serine/threonine-protein kinase 4

Source gene: MAST4

Class: DEG_SCF_FBW7_1

Location: 1018:1024

E3 ligase: FBXW7

DEGRON score: 0.982

ASA_SCORE: 71.5143

COIL: 0.8503

CONS_SCORE: 0.406

DSS_SCORE: 0.6964

HELIX: 0.0866

FCONS_SCORE: 1.0921

RIG_SCORE: 0.6793

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.L1030M	TCGA-D3-A2J8	SKCM	TCGA	VTTPAST	DEG_SCF_FBW7_1	0.1667
p.P1021Q	TCGA-DU-7298	LGG	TCGA	VTTPAST	DEG_SCF_FBW7_1	0.7035
p.Q1013K	TCGA-EB-A3XF	SKCM	TCGA	VTTPAST	DEG_SCF_FBW7_1	0.1944
p.E1017K	TCGA-GD-A6C6	BLCA	TCGA	VTTPAST	DEG_SCF_FBW7_1	0.3056
p.I1018M	DO26404	LUAD	ICGC	VTTPAST	DEG_SCF_FBW7_1	0.7618

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O15021	Microtubule-associated serine/threonine-protein kinase 4	DEG_SCF_FBW7_1	1018:1024	VTTPAST	FBXW7	0.982	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons