DegronMD

Uniprot ID: Q9Y2H9

Source protein: Microtubule-associated serine/threonine-protein kinase 1

Source gene: MAST1

Class: LIG_APCC_ABBA_1

Location: 662:667

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.9918

ASA_SCORE: 60

COIL: 0.795

CONS_SCORE: 0.7078

DSS_SCORE: 0.3447

HELIX: 0.0097

FCONS_SCORE: 0.9446

RIG_SCORE: 0.7758

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.S668L	TCGA-A6-6781	COAD	TCGA	FIPHLE	LIG_APCC_ABBA_1	0.3056
p.S668L	TCGA-E2-A152	BRCA	TCGA	FIPHLE	LIG_APCC_ABBA_1	0.3056
p.S668L	DO4449	BRCA	ICGC	FIPHLE	LIG_APCC_ABBA_1	0.3056
p.S668L	DO8447	COAD	ICGC	FIPHLE	LIG_APCC_ABBA_1	0.3056
p.E661K	TCGA-FS-A1ZP	SKCM	TCGA	FIPHLE	LIG_APCC_ABBA_1	0.3056
p.E661K	DO37703	SKCM	ICGC	FIPHLE	LIG_APCC_ABBA_1	0.3056
p.Q658H	TCGA-G2-AA3D	BLCA	TCGA	FIPHLE	LIG_APCC_ABBA_1	0.2222
p.Q658H	DO51884	BLCA	ICGC	FIPHLE	LIG_APCC_ABBA_1	0.2222
p.S673I	SIDM00145	T-Lymphoblastic Leukemia	GDSC	FIPHLE	LIG_APCC_ABBA_1	0.1667
p.S673I	ACH-001127	Leukemia	CCLE	FIPHLE	LIG_APCC_ABBA_1	0.1667
p.S673I	MOLT-4	haematopoietic_and_lymphoid_tissue	COSMIC	FIPHLE	LIG_APCC_ABBA_1	0.1667
p.F662L	ACH-001991	Primary	CCLE	FIPHLE	LIG_APCC_ABBA_1	0.587

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q9Y2H9	Microtubule-associated serine/threonine-protein kinase 1	LIG_APCC_ABBA_1	662:667	FIPHLE	APC,CDC20,FZR1	0.9918	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons