DegronMD

Uniprot ID: Q9Y2H9

Source protein: Microtubule-associated serine/threonine-protein kinase 1

Source gene: MAST1

Class: DEG_SCF_TRCP1_1

Location: 345:351

E3 ligase: BTRC

DEGRON score: 0.6301

ASA_SCORE: 71.8857

COIL: 0.8951

CONS_SCORE: 0.4564

DSS_SCORE: 0.7646

HELIX: 0.0689

FCONS_SCORE: 1.1267

RIG_SCORE: 0.5243

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.D356V	TCGA-33-4583	LUSC	TCGA	DSGGSNT	DEG_SCF_TRCP1_1	0.1944
p.D356V	DO27112	LUSC	ICGC	DSGGSNT	DEG_SCF_TRCP1_1	0.1944
p.N350S	TCGA-EE-A3J5	SKCM	TCGA	DSGGSNT	DEG_SCF_TRCP1_1	0.5958
p.N350S	DO47331	SKCM	ICGC	DSGGSNT	DEG_SCF_TRCP1_1	0.5958
p.D356N	TCGA-YG-AA3P	SKCM	TCGA	DSGGSNT	DEG_SCF_TRCP1_1	0.1944
p.D356N	DO220891	MELA	ICGC	DSGGSNT	DEG_SCF_TRCP1_1	0.1944
p.D356N	DO51300	SKCM	ICGC	DSGGSNT	DEG_SCF_TRCP1_1	0.1944
p.L341V	DO48425	BLCA	ICGC	DSGGSNT	DEG_SCF_TRCP1_1	0.2222
p.G348C	DO229045	LICA	ICGC	DSGGSNT	DEG_SCF_TRCP1_1	0.6489
p.S358C	DO230946	LUSC	ICGC	DSGGSNT	DEG_SCF_TRCP1_1	0.1389
p.S358C	DO224605	LUSC	ICGC	DSGGSNT	DEG_SCF_TRCP1_1	0.1389
p.R361H	SIDM01016	T-Lymphoblastic Leukemia	GDSC	DSGGSNT	DEG_SCF_TRCP1_1	0.0556
p.R361H	ACH-000995	Leukemia	CCLE	DSGGSNT	DEG_SCF_TRCP1_1	0.0556
p.R361H	ACH-001061	Colon/Colorectal Cancer	CCLE	DSGGSNT	DEG_SCF_TRCP1_1	0.0556
p.R361H	Jurkat	haematopoietic_and_lymphoid_tissue	COSMIC	DSGGSNT	DEG_SCF_TRCP1_1	0.0556
p.S346T	SIDM00491	Thyroid Gland Carcinoma	GDSC	DSGGSNT	DEG_SCF_TRCP1_1	0.7116
p.S346T	ACH-001443	Thyroid Cancer	CCLE	DSGGSNT	DEG_SCF_TRCP1_1	0.7116
p.S346T	ASH-3	thyroid	COSMIC	DSGGSNT	DEG_SCF_TRCP1_1	0.7116
p.R357H	Jurkat	haematopoietic_and_lymphoid_tissue	COSMIC	DSGGSNT	DEG_SCF_TRCP1_1	0.1667
p.S342T	ASH-3	thyroid	COSMIC	DSGGSNT	DEG_SCF_TRCP1_1	0.25

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q9Y2H9	Microtubule-associated serine/threonine-protein kinase 1	DEG_SCF_TRCP1_1	345:351	DSGGSNT	BTRC	0.6301	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons