DegronMD

Uniprot ID: Q9Y2H9

Source protein: Microtubule-associated serine/threonine-protein kinase 1

Source gene: MAST1

Class: DEG_APCC_DBOX_1

Location: 752:760

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.9725

ASA_SCORE: 74.8111

COIL: 0.7756

CONS_SCORE: 0.3645

DSS_SCORE: 0.5816

HELIX: 0.1343

FCONS_SCORE: 1.0461

RIG_SCORE: 0.6877

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.R753W	TCGA-EO-A3B0	UCEC	TCGA	KREGLGGLT	DEG_APCC_DBOX_1	0.8634
p.R753W	DO219773	UCEC	ICGC	KREGLGGLT	DEG_APCC_DBOX_1	0.8634
p.G769S	TCGA-T3-A92N	HNSC	TCGA	KREGLGGLT	DEG_APCC_DBOX_1	0.0833
p.G769S	DO219073	HNSC	ICGC	KREGLGGLT	DEG_APCC_DBOX_1	0.0833
p.G744S	SIDM00393	Gastric Carcinoma	GDSC	KREGLGGLT	DEG_APCC_DBOX_1	0.1111
p.G744S	ACH-001653	Gastric Cancer	CCLE	KREGLGGLT	DEG_APCC_DBOX_1	0.1111
p.G744S	SK-GT-2	stomach	COSMIC	KREGLGGLT	DEG_APCC_DBOX_1	0.1111

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q9Y2H9	Microtubule-associated serine/threonine-protein kinase 1	DEG_APCC_DBOX_1	752:760	KREGLGGLT	APC,CDC20,FZR1	0.9725	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons