DegronMD

Uniprot ID: Q9Y2H9

Source protein: Microtubule-associated serine/threonine-protein kinase 1

Source gene: MAST1

Class: DEG_SCF_FBW7_1

Location: 1207:1214

E3 ligase: FBXW7

DEGRON score: 0.9935

ASA_SCORE: 75.85

COIL: 0.8809

CONS_SCORE: 0.4925

DSS_SCORE: 0.7057

HELIX: 0.069

FCONS_SCORE: 1.2093

RIG_SCORE: 0.5789

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.A1208T	TCGA-A5-A0GI	UCEC	TCGA	LAHTPSPT	DEG_SCF_FBW7_1	0.6028
p.A1208T	DO41807	UCEC	ICGC	LAHTPSPT	DEG_SCF_FBW7_1	0.6028
p.G1200D	TCGA-AF-2687	READ	TCGA	LAHTPSPT	DEG_SCF_FBW7_1	0.1389
p.G1200D	DO36902	READ	ICGC	LAHTPSPT	DEG_SCF_FBW7_1	0.1389
p.G1223D	SIDM00487	Colorectal Carcinoma	GDSC	LAHTPSPT	DEG_SCF_FBW7_1	0.0833
p.G1223D	ACH-000963	Colon/Colorectal Cancer	CCLE	LAHTPSPT	DEG_SCF_FBW7_1	0.0833
p.G1223D	CCK-81	large_intestine	COSMIC	LAHTPSPT	DEG_SCF_FBW7_1	0.0833
p.L1204V	ACH-001336	Cervical Cancer	CCLE	LAHTPSPT	DEG_SCF_FBW7_1	0.25

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q9Y2H9	Microtubule-associated serine/threonine-protein kinase 1	DEG_SCF_FBW7_1	1207:1214	LAHTPSPT	FBXW7	0.9935	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons