DegronMD

Uniprot ID: Q86SE5

Source protein: RNA-binding Raly-like protein

Source gene: RALYL

Class: DEG_SPOP_SBC_1

Location: 162:166

E3 ligase: SPOP

DEGRON score: 0.9953

ASA_SCORE: 79.3

COIL: 0.8888

CONS_SCORE: 0.3948

DSS_SCORE: 0.5123

HELIX: 0.0414

FCONS_SCORE: 0.9095

RIG_SCORE: 0.8017

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.R171H	TCGA-06-0185	GBM	TCGA	AVTTT	DEG_SPOP_SBC_1	0.1944
p.R171H	TCGA-BA-5556	HNSC	TCGA	AVTTT	DEG_SPOP_SBC_1	0.1944
p.R171H	TCGA-BR-4280	STAD	TCGA	AVTTT	DEG_SPOP_SBC_1	0.1944
p.R171H	TCGA-DH-5141	LGG	TCGA	AVTTT	DEG_SPOP_SBC_1	0.1944
p.R171H	SIDM01048	Plasma Cell Myeloma	GDSC	AVTTT	DEG_SPOP_SBC_1	0.1944
p.R171H	EJM	haematopoietic_and_lymphoid_tissue	COSMIC	AVTTT	DEG_SPOP_SBC_1	0.1944
p.R164H	TCGA-27-2527	GBM	TCGA	AVTTT	DEG_SPOP_SBC_1	0.8244
p.R164H	TCGA-L5-A43J	ESCA	TCGA	AVTTT	DEG_SPOP_SBC_1	0.8244
p.R164C	TCGA-4Z-AA89	BLCA	TCGA	AVTTT	DEG_SPOP_SBC_1	0.8301
p.R164C	TCGA-LN-A49Y	ESCA	TCGA	AVTTT	DEG_SPOP_SBC_1	0.8301
p.R164C	TCGA-T3-A92N	HNSC	TCGA	AVTTT	DEG_SPOP_SBC_1	0.8301
p.R158C	TCGA-AA-A02R	COAD	TCGA	AVTTT	DEG_SPOP_SBC_1	0.2222
p.R158C	SIDM00548	Squamous Cell Lung Carcinoma	GDSC	AVTTT	DEG_SPOP_SBC_1	0.2222
p.R158C	SIDM01145	Gastric Carcinoma	GDSC	AVTTT	DEG_SPOP_SBC_1	0.2222
p.R158C	SIDM01449	Pancreatic Carcinoma	GDSC	AVTTT	DEG_SPOP_SBC_1	0.2222
p.R158C	LK-2	lung	COSMIC	AVTTT	DEG_SPOP_SBC_1	0.2222
p.R158C	NCI-SNU-16	stomach	COSMIC	AVTTT	DEG_SPOP_SBC_1	0.2222
p.P168L	TCGA-AP-A1DV	UCEC	TCGA	AVTTT	DEG_SPOP_SBC_1	0.2778
p.P168L	TCGA-CG-5721	STAD	TCGA	AVTTT	DEG_SPOP_SBC_1	0.2778
p.P172S	TCGA-BF-AAP0	SKCM	TCGA	AVTTT	DEG_SPOP_SBC_1	0.1667
p.R171C	TCGA-BG-A18B	UCEC	TCGA	AVTTT	DEG_SPOP_SBC_1	0.1944
p.V166I	TCGA-BR-8682	STAD	TCGA	AVTTT	DEG_SPOP_SBC_1	0.7076
p.P161L	TCGA-DA-A1HY	SKCM	TCGA	AVTTT	DEG_SPOP_SBC_1	0.3056
p.P163S	TCGA-FS-A1ZQ	SKCM	TCGA	AVTTT	DEG_SPOP_SBC_1	0.6752
p.R164G	TCGA-L9-A7SV	LUAD	TCGA	AVTTT	DEG_SPOP_SBC_1	0.7568
p.R167L	DO228971	LICA	ICGC	AVTTT	DEG_SPOP_SBC_1	0.3056
p.R168K	DO49085	LUSC	ICGC	AVTTT	DEG_SPOP_SBC_1	0.2778
p.P159S	DO220875	MELA	ICGC	AVTTT	DEG_SPOP_SBC_1	0.25
p.P159S	DO219462	SKCM	ICGC	AVTTT	DEG_SPOP_SBC_1	0.25
p.R167C	DO220894	MELA	ICGC	AVTTT	DEG_SPOP_SBC_1	0.3056
p.P155L	DO222542	MELA	ICGC	AVTTT	DEG_SPOP_SBC_1	0.1389
p.P155L	DO38192	STAD	ICGC	AVTTT	DEG_SPOP_SBC_1	0.1389
p.P155L	DO43186	UCEC	ICGC	AVTTT	DEG_SPOP_SBC_1	0.1389
p.G169R	DO48665	SKCM	ICGC	AVTTT	DEG_SPOP_SBC_1	0.25
p.R171S	SIDM00046	Non-Small Cell Lung Carcinoma	GDSC	AVTTT	DEG_SPOP_SBC_1	0.1944
p.R171S	H3255	lung	COSMIC	AVTTT	DEG_SPOP_SBC_1	0.1944
p.P172T	SIDM01150	Non-Small Cell Lung Carcinoma	GDSC	AVTTT	DEG_SPOP_SBC_1	0.1667
p.P172T	NCI-H838	lung	COSMIC	AVTTT	DEG_SPOP_SBC_1	0.1667
p.R158S	ACH-000109	Lung Cancer	CCLE	AVTTT	DEG_SPOP_SBC_1	0.2222
p.R158S	H3255	lung	COSMIC	AVTTT	DEG_SPOP_SBC_1	0.2222
p.R167H	ACH-000320	Pancreatic Cancer	CCLE	AVTTT	DEG_SPOP_SBC_1	0.3056
p.R167H	ACH-000412	Colon/Colorectal Cancer	CCLE	AVTTT	DEG_SPOP_SBC_1	0.3056
p.R167H	ACH-000660	Lymphoma	CCLE	AVTTT	DEG_SPOP_SBC_1	0.3056
p.R167H	ACH-000776	Brain Cancer	CCLE	AVTTT	DEG_SPOP_SBC_1	0.3056
p.R167H	ACH-001127	Leukemia	CCLE	AVTTT	DEG_SPOP_SBC_1	0.3056
p.P159T	ACH-000416	Lung Cancer	CCLE	AVTTT	DEG_SPOP_SBC_1	0.25
p.P159T	NCI-H838	lung	COSMIC	AVTTT	DEG_SPOP_SBC_1	0.25
p.R158H	ACH-000821	Myeloma	CCLE	AVTTT	DEG_SPOP_SBC_1	0.2222
p.R158H	EJM	haematopoietic_and_lymphoid_tissue	COSMIC	AVTTT	DEG_SPOP_SBC_1	0.2222
p.T166I	ACH-001669	Leukemia	CCLE	AVTTT	DEG_SPOP_SBC_1	0.8189
p.T166I	ACH-002238	Leukemia	CCLE	AVTTT	DEG_SPOP_SBC_1	0.8189
p.T166I	GR-ST	haematopoietic_and_lymphoid_tissue	COSMIC	AVTTT	DEG_SPOP_SBC_1	0.8189
p.V153I	ACH-002042	Thyroid Cancer	CCLE	AVTTT	DEG_SPOP_SBC_1	0.0833
p.T155I	GR-ST	haematopoietic_and_lymphoid_tissue	COSMIC	AVTTT	DEG_SPOP_SBC_1	0.1389
p.Q158K	SW900	lung	COSMIC	AVTTT	DEG_SPOP_SBC_1	0.2222
p.A172V	SNU-1040	large_intestine	COSMIC	AVTTT	DEG_SPOP_SBC_1	0.1667
p.C173Y	SNU-283	large_intestine	COSMIC	AVTTT	DEG_SPOP_SBC_1	0.1389

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O15054	Lysine-specific demethylase 6B	DEG_SPOP_SBC_1	750:754	AVTTT	SPOP	0.963	More...
O95104	SR-related and CTD-associated factor 4	DEG_SPOP_SBC_1	284:288	AVTTT	SPOP	0.5941	More...
P52756	RNA-binding protein 5	DEG_SPOP_SBC_1	400:404	AVTTT	SPOP	0.6447	More...
Q6Q4G3	Aminopeptidase Q	DEG_SPOP_SBC_1	79:83	AVTTT	SPOP	0.9845	More...
Q86SE5	RNA-binding Raly-like protein	DEG_SPOP_SBC_1	162:166	AVTTT	SPOP	0.9953	More...
Q8IWI9	MAX gene-associated protein	DEG_SPOP_SBC_1	1596:1600	AVTTT	SPOP	0.5077	More...
Q9H3R2	Mucin-13	DEG_SPOP_SBC_1	27:31	AVTTT	SPOP	0.8418	More...
Q9NSU2	Three-prime repair exonuclease 1	DEG_SPOP_SBC_1	247:251	AVTTT	SPOP	0.9952	More...
Q9UKJ1	Paired immunoglobulin-like type 2 receptor alpha	DEG_SPOP_SBC_1	152:156	AVTTT	SPOP	0.5634	More...
Q9Y2H9	Microtubule-associated serine/threonine-protein kinase 1	DEG_SPOP_SBC_1	1048:1052	AVTTT	SPOP	0.8655	More...
Q9UKJ0	Paired immunoglobulin-like type 2 receptor beta	DEG_SPOP_SBC_1	152:156	AVTTT	SPOP	0.7899	More...
A2A368	Melanoma-associated antigen B16	DEG_SPOP_SBC_1	74:78	AVTTT	SPOP	0.5345	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: AVTTT

Degron related mutations and impact score

Drug responses associated with RALYL mutations

All proteins holding degron of AVTTT