DegronMD - Q86SE5(RALYL)

Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.R171H	TCGA-06-0185	GBM	TCGA	AVTTT	DEG_SPOP_SBC_1	162:166	Mutation rewiring degron network	0.1944
p.R171H	TCGA-BA-5556	HNSC	TCGA	AVTTT	DEG_SPOP_SBC_1	162:166	Mutation rewiring degron network	0.1944
p.R171H	TCGA-BR-4280	STAD	TCGA	AVTTT	DEG_SPOP_SBC_1	162:166	Mutation rewiring degron network	0.1944
p.R171H	TCGA-DH-5141	LGG	TCGA	AVTTT	DEG_SPOP_SBC_1	162:166	Mutation rewiring degron network	0.1944
p.R171H	SIDM01048	Plasma Cell Myeloma	GDSC	AVTTT	DEG_SPOP_SBC_1	162:166	Mutation rewiring degron network	0.1944
p.R171H	EJM	haematopoietic and lymphoid tissue	COSMIC	AVTTT	DEG_SPOP_SBC_1	162:166	Mutation rewiring degron network	0.1944
p.R164H	TCGA-27-2527	GBM	TCGA	AVTTT	DEG_SPOP_SBC_1	162:166	Mutation altering degron motif	0.8244
p.R164H	TCGA-L5-A43J	ESCA	TCGA	AVTTT	DEG_SPOP_SBC_1	162:166	Mutation altering degron motif	0.8244
p.R164C	TCGA-4Z-AA89	BLCA	TCGA	AVTTT	DEG_SPOP_SBC_1	162:166	Mutation altering degron motif	0.8301
p.R164C	TCGA-LN-A49Y	ESCA	TCGA	AVTTT	DEG_SPOP_SBC_1	162:166	Mutation altering degron motif	0.8301
p.R164C	TCGA-T3-A92N	HNSC	TCGA	AVTTT	DEG_SPOP_SBC_1	162:166	Mutation altering degron motif	0.8301
p.R158C	TCGA-AA-A02R	COAD	TCGA	AVTTT	DEG_SPOP_SBC_1	162:166	Mutation rewiring degron network	0.2222
p.R158C	SIDM00548	Squamous Cell Lung Carcinoma	GDSC	AVTTT	DEG_SPOP_SBC_1	162:166	Mutation rewiring degron network	0.2222
p.R158C	SIDM01145	Gastric Carcinoma	GDSC	AVTTT	DEG_SPOP_SBC_1	162:166	Mutation rewiring degron network	0.2222
p.R158C	SIDM01449	Pancreatic Carcinoma	GDSC	AVTTT	DEG_SPOP_SBC_1	162:166	Mutation rewiring degron network	0.2222
p.R158C	LK-2	lung	COSMIC	AVTTT	DEG_SPOP_SBC_1	162:166	Mutation rewiring degron network	0.2222
p.R158C	NCI-SNU-16	stomach	COSMIC	AVTTT	DEG_SPOP_SBC_1	162:166	Mutation rewiring degron network	0.2222
p.P168L	TCGA-AP-A1DV	UCEC	TCGA	AVTTT	DEG_SPOP_SBC_1	162:166	Mutation rewiring degron network	0.2778
p.P168L	TCGA-CG-5721	STAD	TCGA	AVTTT	DEG_SPOP_SBC_1	162:166	Mutation rewiring degron network	0.2778
p.P172S	TCGA-BF-AAP0	SKCM	TCGA	AVTTT	DEG_SPOP_SBC_1	162:166	Mutation rewiring degron network	0.1667
p.R171C	TCGA-BG-A18B	UCEC	TCGA	AVTTT	DEG_SPOP_SBC_1	162:166	Mutation rewiring degron network	0.1944
p.V166I	TCGA-BR-8682	STAD	TCGA	AVTTT	DEG_SPOP_SBC_1	162:166	Mutation altering degron motif	0.7076
p.P161L	TCGA-DA-A1HY	SKCM	TCGA	AVTTT	DEG_SPOP_SBC_1	162:166	Mutation rewiring degron network	0.3056
p.P163S	TCGA-FS-A1ZQ	SKCM	TCGA	AVTTT	DEG_SPOP_SBC_1	162:166	Mutation altering degron motif	0.6752
p.R164G	TCGA-L9-A7SV	LUAD	TCGA	AVTTT	DEG_SPOP_SBC_1	162:166	Mutation altering degron motif	0.7568
p.R167L	DO228971	LICA	ICGC	AVTTT	DEG_SPOP_SBC_1	162:166	Mutation rewiring degron network	0.3056
p.R168K	DO49085	LUSC	ICGC	AVTTT	DEG_SPOP_SBC_1	162:166	Mutation rewiring degron network	0.2778
p.P159S	DO220875	MELA	ICGC	AVTTT	DEG_SPOP_SBC_1	162:166	Mutation rewiring degron network	0.25
p.P159S	DO219462	SKCM	ICGC	AVTTT	DEG_SPOP_SBC_1	162:166	Mutation rewiring degron network	0.25
p.R167C	DO220894	MELA	ICGC	AVTTT	DEG_SPOP_SBC_1	162:166	Mutation rewiring degron network	0.3056
p.P155L	DO222542	MELA	ICGC	AVTTT	DEG_SPOP_SBC_1	162:166	Mutation rewiring degron network	0.1389
p.P155L	DO38192	STAD	ICGC	AVTTT	DEG_SPOP_SBC_1	162:166	Mutation rewiring degron network	0.1389
p.P155L	DO43186	UCEC	ICGC	AVTTT	DEG_SPOP_SBC_1	162:166	Mutation rewiring degron network	0.1389
p.G169R	DO48665	SKCM	ICGC	AVTTT	DEG_SPOP_SBC_1	162:166	Mutation rewiring degron network	0.25
p.R171S	SIDM00046	Non-Small Cell Lung Carcinoma	GDSC	AVTTT	DEG_SPOP_SBC_1	162:166	Mutation rewiring degron network	0.1944
p.R171S	H3255	lung	COSMIC	AVTTT	DEG_SPOP_SBC_1	162:166	Mutation rewiring degron network	0.1944
p.P172T	SIDM01150	Non-Small Cell Lung Carcinoma	GDSC	AVTTT	DEG_SPOP_SBC_1	162:166	Mutation rewiring degron network	0.1667
p.P172T	NCI-H838	lung	COSMIC	AVTTT	DEG_SPOP_SBC_1	162:166	Mutation rewiring degron network	0.1667
p.R158S	ACH-000109	Lung Cancer	CCLE	AVTTT	DEG_SPOP_SBC_1	162:166	Mutation rewiring degron network	0.2222
p.R158S	H3255	lung	COSMIC	AVTTT	DEG_SPOP_SBC_1	162:166	Mutation rewiring degron network	0.2222
p.R167H	ACH-000320	Pancreatic Cancer	CCLE	AVTTT	DEG_SPOP_SBC_1	162:166	Mutation rewiring degron network	0.3056
p.R167H	ACH-000412	Colon/Colorectal Cancer	CCLE	AVTTT	DEG_SPOP_SBC_1	162:166	Mutation rewiring degron network	0.3056
p.R167H	ACH-000660	Lymphoma	CCLE	AVTTT	DEG_SPOP_SBC_1	162:166	Mutation rewiring degron network	0.3056
p.R167H	ACH-000776	Brain Cancer	CCLE	AVTTT	DEG_SPOP_SBC_1	162:166	Mutation rewiring degron network	0.3056
p.R167H	ACH-001127	Leukemia	CCLE	AVTTT	DEG_SPOP_SBC_1	162:166	Mutation rewiring degron network	0.3056
p.P159T	ACH-000416	Lung Cancer	CCLE	AVTTT	DEG_SPOP_SBC_1	162:166	Mutation rewiring degron network	0.25
p.P159T	NCI-H838	lung	COSMIC	AVTTT	DEG_SPOP_SBC_1	162:166	Mutation rewiring degron network	0.25
p.R158H	ACH-000821	Myeloma	CCLE	AVTTT	DEG_SPOP_SBC_1	162:166	Mutation rewiring degron network	0.2222
p.R158H	EJM	haematopoietic and lymphoid tissue	COSMIC	AVTTT	DEG_SPOP_SBC_1	162:166	Mutation rewiring degron network	0.2222
p.T166I	ACH-001669	Leukemia	CCLE	AVTTT	DEG_SPOP_SBC_1	162:166	Mutation altering degron motif	0.8189
p.T166I	ACH-002238	Leukemia	CCLE	AVTTT	DEG_SPOP_SBC_1	162:166	Mutation altering degron motif	0.8189
p.T166I	GR-ST	haematopoietic and lymphoid tissue	COSMIC	AVTTT	DEG_SPOP_SBC_1	162:166	Mutation altering degron motif	0.8189
p.V153I	ACH-002042	Thyroid Cancer	CCLE	AVTTT	DEG_SPOP_SBC_1	162:166	Mutation rewiring degron network	0.0833
p.T155I	GR-ST	haematopoietic and lymphoid tissue	COSMIC	AVTTT	DEG_SPOP_SBC_1	162:166	Mutation rewiring degron network	0.1389
p.Q158K	SW900	lung	COSMIC	AVTTT	DEG_SPOP_SBC_1	162:166	Mutation rewiring degron network	0.2222
p.A172V	SNU-1040	large intestine	COSMIC	AVTTT	DEG_SPOP_SBC_1	162:166	Mutation rewiring degron network	0.1667
p.C173Y	SNU-283	large intestine	COSMIC	AVTTT	DEG_SPOP_SBC_1	162:166	Mutation rewiring degron network	0.1389

DegronMD: protein-targeted degradation, mutation and drug response to degrons

RALYL

UniProt ID: Q86SE5

Entrez ID: 138046

Protein name: RNA-binding Raly-like protein (hRALYL) (Heterogeneous nuclear ribonucleoprotein C-like 3) (hnRNP core protein C-like 3)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for RALYL in