DegronMD

Uniprot ID: O15054

Source protein: Lysine-specific demethylase 6B

Source gene: KDM6B

Class: DEG_SCF_FBW7_1

Location: 453:460

E3 ligase: FBXW7

DEGRON score: 0.923

ASA_SCORE: 93.6

COIL: 0.952

CONS_SCORE: 0.4719

DSS_SCORE: 0.6458

HELIX: 0.0209

FCONS_SCORE: 1.1531

RIG_SCORE: 0.5549

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.P470A	TCGA-33-4538	LUSC	TCGA	PAATPHLS	DEG_SCF_FBW7_1	0.0556
p.P470A	DO26695	LUSC	ICGC	PAATPHLS	DEG_SCF_FBW7_1	0.0556
p.R446L	TCGA-D3-A2JB	SKCM	TCGA	PAATPHLS	DEG_SCF_FBW7_1	0.1389
p.R446L	DO47607	SKCM	ICGC	PAATPHLS	DEG_SCF_FBW7_1	0.1389
p.S444I	TCGA-IB-7651	PAAD	TCGA	PAATPHLS	DEG_SCF_FBW7_1	0.0833
p.S444I	DO46657	PAAD	ICGC	PAATPHLS	DEG_SCF_FBW7_1	0.0833
p.R446W	TCGA-MY-A913	CESC	TCGA	PAATPHLS	DEG_SCF_FBW7_1	0.1389
p.R446W	DO49980	CESC	ICGC	PAATPHLS	DEG_SCF_FBW7_1	0.1389
p.R446W	SIDM00660	Colorectal Carcinoma	GDSC	PAATPHLS	DEG_SCF_FBW7_1	0.1389
p.R446W	ACH-000985	Colon/Colorectal Cancer	CCLE	PAATPHLS	DEG_SCF_FBW7_1	0.1389
p.R446W	LS-411N	large_intestine	COSMIC	PAATPHLS	DEG_SCF_FBW7_1	0.1389
p.A454D	DO50387	ESAD	ICGC	PAATPHLS	DEG_SCF_FBW7_1	0.6682
p.P448L	DO37432	SKCM	ICGC	PAATPHLS	DEG_SCF_FBW7_1	0.1944

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O15054	Lysine-specific demethylase 6B	DEG_SCF_FBW7_1	453:460	PAATPHLS	FBXW7	0.923	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons