DegronMD

Uniprot ID: O00592

Source protein: Podocalyxin

Source gene: PODXL

Class: DEG_SCF_FBW7_1

Location: 47:52

E3 ligase: FBXW7

DEGRON score: 0.8404

ASA_SCORE: 83.3333

COIL: 0.8857

CONS_SCORE: 0.2358

DSS_SCORE: 0.5949

HELIX: 0.0348

FCONS_SCORE: 0.7504

RIG_SCORE: 0.6502

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.V53A	TCGA-AA-3811	COAD	TCGA	PTPASS	DEG_SCF_FBW7_1	0.3056
p.I55T	TCGA-AP-A1DV	UCEC	TCGA	PTPASS	DEG_SCF_FBW7_1	0.25
p.P47L	TCGA-BR-7851	STAD	TCGA	PTPASS	DEG_SCF_FBW7_1	0.6471
p.P49S	TCGA-D3-A8GB	SKCM	TCGA	PTPASS	DEG_SCF_FBW7_1	0.6752
p.P49S	DO15623	HNSC	ICGC	PTPASS	DEG_SCF_FBW7_1	0.6752
p.P47S	TCGA-D6-6516	HNSC	TCGA	PTPASS	DEG_SCF_FBW7_1	0.6752
p.A46T	TCGA-EO-A22U	UCEC	TCGA	PTPASS	DEG_SCF_FBW7_1	0.3056
p.A57T	TCGA-IB-7651	PAAD	TCGA	PTPASS	DEG_SCF_FBW7_1	0.1944
p.V55A	DO7962	COAD	ICGC	PTPASS	DEG_SCF_FBW7_1	0.25
p.A59T	DO46657	PAAD	ICGC	PTPASS	DEG_SCF_FBW7_1	0.1389
p.P51S	DO50280	SKCM	ICGC	PTPASS	DEG_SCF_FBW7_1	0.6752
p.P49L	DO38711	STAD	ICGC	PTPASS	DEG_SCF_FBW7_1	0.7582
p.I57T	DO43186	UCEC	ICGC	PTPASS	DEG_SCF_FBW7_1	0.1944
p.A48T	DO43755	UCEC	ICGC	PTPASS	DEG_SCF_FBW7_1	0.7139

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O00592	Podocalyxin	DEG_SCF_FBW7_1	47:52	PTPASS	FBXW7	0.8404	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons