DegronMD

Uniprot ID: O00592

Source protein: Podocalyxin

Source gene: PODXL

Class: DEG_SCF_FBW7_1

Location: 197:204

E3 ligase: FBXW7

DEGRON score: 0.9797

ASA_SCORE: 88.025

COIL: 0.9539

CONS_SCORE: 0.3419

DSS_SCORE: 0.7234

HELIX: 0.0188

FCONS_SCORE: 0.9731

RIG_SCORE: 0.5849

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.R190Q	TCGA-5C-A9VH	LIHC	TCGA	PVATPTSS	DEG_SCF_FBW7_1	0.1389
p.R190Q	TCGA-BR-8487	STAD	TCGA	PVATPTSS	DEG_SCF_FBW7_1	0.1389
p.H208Y	TCGA-68-8250	LUSC	TCGA	PVATPTSS	DEG_SCF_FBW7_1	0.2222
p.H208Y	DO219219	LUSC	ICGC	PVATPTSS	DEG_SCF_FBW7_1	0.2222
p.T195M	TCGA-73-4668	LUAD	TCGA	PVATPTSS	DEG_SCF_FBW7_1	0.7222
p.T195M	TCGA-CR-7397	HNSC	TCGA	PVATPTSS	DEG_SCF_FBW7_1	0.7222
p.P189S	TCGA-BF-A5EP	SKCM	TCGA	PVATPTSS	DEG_SCF_FBW7_1	0.1111
p.S213L	TCGA-EE-A2MF	SKCM	TCGA	PVATPTSS	DEG_SCF_FBW7_1	0.0833
p.P192L	TCGA-LN-A4A9	ESCA	TCGA	PVATPTSS	DEG_SCF_FBW7_1	0.1944
p.H206Y	TCGA-O2-A52Q	LUSC	TCGA	PVATPTSS	DEG_SCF_FBW7_1	0.2778
p.Q193K	DO224942	BRCA	ICGC	PVATPTSS	DEG_SCF_FBW7_1	0.6667
p.Q193K	DO229041	LICA	ICGC	PVATPTSS	DEG_SCF_FBW7_1	0.6667
p.P188L	DO222952	BTCA	ICGC	PVATPTSS	DEG_SCF_FBW7_1	0.5278
p.S196L	DO229010	COCA	ICGC	PVATPTSS	DEG_SCF_FBW7_1	0.3056
p.S196L	DO229016	COCA	ICGC	PVATPTSS	DEG_SCF_FBW7_1	0.3056
p.S196L	DO229003	COCA	ICGC	PVATPTSS	DEG_SCF_FBW7_1	0.3056
p.S196L	DO229005	COCA	ICGC	PVATPTSS	DEG_SCF_FBW7_1	0.3056
p.S196L	DO52365	LUSC	ICGC	PVATPTSS	DEG_SCF_FBW7_1	0.3056
p.T197M	DO228123	EOPC	ICGC	PVATPTSS	DEG_SCF_FBW7_1	0.7423
p.T197M	DO50365	ESAD	ICGC	PVATPTSS	DEG_SCF_FBW7_1	0.7423
p.T197M	DO15583	HNSC	ICGC	PVATPTSS	DEG_SCF_FBW7_1	0.7423
p.T197M	DO23961	LUAD	ICGC	PVATPTSS	DEG_SCF_FBW7_1	0.7423
p.L211F	DO11854	GBM	ICGC	PVATPTSS	DEG_SCF_FBW7_1	0.25
p.H198N	DO229032	LICA	ICGC	PVATPTSS	DEG_SCF_FBW7_1	0.7423
p.S190R	DO229045	LICA	ICGC	PVATPTSS	DEG_SCF_FBW7_1	0.1389
p.R192Q	DO52166	LIHC	ICGC	PVATPTSS	DEG_SCF_FBW7_1	0.1944
p.R192Q	DO47867	STAD	ICGC	PVATPTSS	DEG_SCF_FBW7_1	0.1944
p.P188T	DO26993	LUSC	ICGC	PVATPTSS	DEG_SCF_FBW7_1	0.5278
p.H210Y	DO26993	LUSC	ICGC	PVATPTSS	DEG_SCF_FBW7_1	0.1667
p.P191S	DO223906	SKCM	ICGC	PVATPTSS	DEG_SCF_FBW7_1	0.1667
p.I212M	ACH-001991	Primary	CCLE	PVATPTSS	DEG_SCF_FBW7_1	0.1111

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: PVATPTSS

Degron related mutations and impact score

Drug responses associated with PODXL mutations

All proteins holding degron of PVATPTSS

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O00592	Podocalyxin	DEG_SCF_FBW7_1	197:204	PVATPTSS	FBXW7	0.9797	More...