DegronMD

Uniprot ID: O00592

Source protein: Podocalyxin

Source gene: PODXL

Class: DEG_SCF_FBW7_1

Location: 178:184

E3 ligase: FBXW7

DEGRON score: 0.9822

ASA_SCORE: 99.3286

COIL: 0.9467

CONS_SCORE: 0.2926

DSS_SCORE: 0.7872

HELIX: 0.0083

FCONS_SCORE: 0.8272

RIG_SCORE: 0.616

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.R190Q	TCGA-5C-A9VH	LIHC	TCGA	LTTPHPT	DEG_SCF_FBW7_1	0.1667
p.R190Q	TCGA-BR-8487	STAD	TCGA	LTTPHPT	DEG_SCF_FBW7_1	0.1667
p.P183S	TCGA-66-2756	LUSC	TCGA	LTTPHPT	DEG_SCF_FBW7_1	0.5641
p.P186T	TCGA-68-8250	LUSC	TCGA	LTTPHPT	DEG_SCF_FBW7_1	0.2778
p.P189S	TCGA-BF-A5EP	SKCM	TCGA	LTTPHPT	DEG_SCF_FBW7_1	0.1944
p.P192L	TCGA-LN-A4A9	ESCA	TCGA	LTTPHPT	DEG_SCF_FBW7_1	0.1111
p.Q193K	DO224942	BRCA	ICGC	LTTPHPT	DEG_SCF_FBW7_1	0.5278
p.Q193K	DO229041	LICA	ICGC	LTTPHPT	DEG_SCF_FBW7_1	0.5278
p.H184Y	DO1160	BRCA	ICGC	LTTPHPT	DEG_SCF_FBW7_1	0.7229
p.T181M	DO222574	BTCA	ICGC	LTTPHPT	DEG_SCF_FBW7_1	0.7423
p.P188L	DO222952	BTCA	ICGC	LTTPHPT	DEG_SCF_FBW7_1	0.6667
p.A177E	DO229041	LICA	ICGC	LTTPHPT	DEG_SCF_FBW7_1	0.3056
p.S190R	DO229045	LICA	ICGC	LTTPHPT	DEG_SCF_FBW7_1	0.1667
p.R192Q	DO52166	LIHC	ICGC	LTTPHPT	DEG_SCF_FBW7_1	0.1111
p.R192Q	DO47867	STAD	ICGC	LTTPHPT	DEG_SCF_FBW7_1	0.1111
p.P188T	DO26993	LUSC	ICGC	LTTPHPT	DEG_SCF_FBW7_1	0.6667
p.P185S	DO27128	LUSC	ICGC	LTTPHPT	DEG_SCF_FBW7_1	0.75
p.P191S	DO223906	SKCM	ICGC	LTTPHPT	DEG_SCF_FBW7_1	0.1389
p.T169I	DO42568	UCEC	ICGC	LTTPHPT	DEG_SCF_FBW7_1	0.0833
p.P186R	SIDM00775	Non-Small Cell Lung Carcinoma	GDSC	LTTPHPT	DEG_SCF_FBW7_1	0.2778
p.P186R	ACH-000785	Lung Cancer	CCLE	LTTPHPT	DEG_SCF_FBW7_1	0.2778
p.P186R	NCI-H2126	lung	COSMIC	LTTPHPT	DEG_SCF_FBW7_1	0.2778

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O00592	Podocalyxin	DEG_SCF_FBW7_1	178:184	LTTPHPT	FBXW7	0.9822	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons