DegronMD

Uniprot ID: O00592

Source protein: Podocalyxin

Source gene: PODXL

Class: DEG_SCF_FBW7_1

Location: 328:334

E3 ligase: FBXW7

DEGRON score: 0.9939

ASA_SCORE: 93.8286

COIL: 0.9477

CONS_SCORE: 0.4442

DSS_SCORE: 0.6085

HELIX: 0.016

FCONS_SCORE: 1.2213

RIG_SCORE: 0.5964

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.T330P	TCGA-AP-A056	UCEC	TCGA	PKTPSPT	DEG_SCF_FBW7_1	0.7031
p.R326Q	TCGA-AP-A1DV	UCEC	TCGA	PKTPSPT	DEG_SCF_FBW7_1	0.2778
p.R326Q	TCGA-AZ-4315	COAD	TCGA	PKTPSPT	DEG_SCF_FBW7_1	0.2778
p.R326Q	SIDM00178	Melanoma	GDSC	PKTPSPT	DEG_SCF_FBW7_1	0.2778
p.R326Q	ACH-002386	Skin Cancer	CCLE	PKTPSPT	DEG_SCF_FBW7_1	0.2778
p.E338K	TCGA-B5-A11E	UCEC	TCGA	PKTPSPT	DEG_SCF_FBW7_1	0.2222
p.W341L	TCGA-ER-A1A1	SKCM	TCGA	PKTPSPT	DEG_SCF_FBW7_1	0.1389
p.H339P	DO224904	BRCA	ICGC	PKTPSPT	DEG_SCF_FBW7_1	0.6389
p.S318C	DO219629	BRCA	ICGC	PKTPSPT	DEG_SCF_FBW7_1	0.0556
p.R328Q	DO8842	COAD	ICGC	PKTPSPT	DEG_SCF_FBW7_1	0.7329
p.R328Q	DO43186	UCEC	ICGC	PKTPSPT	DEG_SCF_FBW7_1	0.7329
p.S319N	DO14918	HNSC	ICGC	PKTPSPT	DEG_SCF_FBW7_1	0.0833
p.A338D	DO228974	LICA	ICGC	PKTPSPT	DEG_SCF_FBW7_1	0.2222
p.T326N	DO229019	LICA	ICGC	PKTPSPT	DEG_SCF_FBW7_1	0.2778
p.T325N	DO229038	LICA	ICGC	PKTPSPT	DEG_SCF_FBW7_1	0.25
p.P333S	DO222868	MELA	ICGC	PKTPSPT	DEG_SCF_FBW7_1	0.5641
p.L325F	DO46380	OV	ICGC	PKTPSPT	DEG_SCF_FBW7_1	0.25
p.W343L	DO37413	SKCM	ICGC	PKTPSPT	DEG_SCF_FBW7_1	0.1944
p.E340K	DO41644	UCEC	ICGC	PKTPSPT	DEG_SCF_FBW7_1	0.1667
p.T332P	DO43971	UCEC	ICGC	PKTPSPT	DEG_SCF_FBW7_1	0.7031
p.P328L	SIDM00545	Melanoma	GDSC	PKTPSPT	DEG_SCF_FBW7_1	0.6471
p.P328L	ACH-000987	Skin Cancer	CCLE	PKTPSPT	DEG_SCF_FBW7_1	0.6471
p.P328L	Mewo	skin	COSMIC	PKTPSPT	DEG_SCF_FBW7_1	0.6471
p.A336V	SIDM00511	Small Cell Lung Carcinoma	GDSC	PKTPSPT	DEG_SCF_FBW7_1	0.2778
p.A336V	ACH-000257	Lung Cancer	CCLE	PKTPSPT	DEG_SCF_FBW7_1	0.2778
p.A336V	COR-L279	lung	COSMIC	PKTPSPT	DEG_SCF_FBW7_1	0.2778
p.T334A	SIDM00567	Other Solid Cancers	GDSC	PKTPSPT	DEG_SCF_FBW7_1	0.7139
p.T334A	ACH-000776	Brain Cancer	CCLE	PKTPSPT	DEG_SCF_FBW7_1	0.7139
p.T334A	ONS-76	central_nervous_system	COSMIC	PKTPSPT	DEG_SCF_FBW7_1	0.7139
p.P328S	ACH-001067	Brain Cancer	CCLE	PKTPSPT	DEG_SCF_FBW7_1	0.6752
p.D341E	HCC-827	lung	COSMIC	PKTPSPT	DEG_SCF_FBW7_1	0.1389

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: PKTPSPT

Degron related mutations and impact score

Drug responses associated with PODXL mutations

All proteins holding degron of PKTPSPT

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O00592	Podocalyxin	DEG_SCF_FBW7_1	328:334	PKTPSPT	FBXW7	0.9939	More...