DegronMD

Uniprot ID: Q8N3K9

Source protein: Cardiomyopathy-associated protein 5

Source gene: CMYA5

Class: DEG_SCF_FBW7_2

Location: 515:522

E3 ligase: FBXW7

DEGRON score: 0.9418

ASA_SCORE: 103.175

COIL: 0.9495

CONS_SCORE: 0.3016

DSS_SCORE: 0.6316

HELIX: 0.0215

FCONS_SCORE: 0.9458

RIG_SCORE: 0.6997

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.P519T	TCGA-55-6712	LUAD	TCGA	IAITPEPE	DEG_SCF_FBW7_2	0.7031
p.P519T	DO25310	LUAD	ICGC	IAITPEPE	DEG_SCF_FBW7_2	0.7031
p.E529Q	TCGA-56-7730	LUSC	TCGA	IAITPEPE	DEG_SCF_FBW7_2	0.1389
p.E529Q	DO26617	LUSC	ICGC	IAITPEPE	DEG_SCF_FBW7_2	0.1389
p.V532I	TCGA-76-4926	GBM	TCGA	IAITPEPE	DEG_SCF_FBW7_2	0.0556
p.V532I	DO12478	GBM	ICGC	IAITPEPE	DEG_SCF_FBW7_2	0.0556
p.V532I	SIDM01293	Colorectal Carcinoma	GDSC	IAITPEPE	DEG_SCF_FBW7_2	0.0556
p.D523Y	TCGA-AG-A002	READ	TCGA	IAITPEPE	DEG_SCF_FBW7_2	0.3056
p.D523Y	DO222762	COCA	ICGC	IAITPEPE	DEG_SCF_FBW7_2	0.3056
p.L513I	TCGA-B5-A0K3	UCEC	TCGA	IAITPEPE	DEG_SCF_FBW7_2	0.2778
p.L513I	DO43314	UCEC	ICGC	IAITPEPE	DEG_SCF_FBW7_2	0.2778
p.I531N	TCGA-D1-A103	UCEC	TCGA	IAITPEPE	DEG_SCF_FBW7_2	0.0833
p.I531N	DO42312	UCEC	ICGC	IAITPEPE	DEG_SCF_FBW7_2	0.0833
p.E530K	TCGA-IB-7651	PAAD	TCGA	IAITPEPE	DEG_SCF_FBW7_2	0.1111
p.E530K	DO46657	PAAD	ICGC	IAITPEPE	DEG_SCF_FBW7_2	0.1111
p.E530G	TCGA-W3-A828	SKCM	TCGA	IAITPEPE	DEG_SCF_FBW7_2	0.1111
p.E530G	DO51273	SKCM	ICGC	IAITPEPE	DEG_SCF_FBW7_2	0.1111
p.I531M	DO233900	GACA	ICGC	IAITPEPE	DEG_SCF_FBW7_2	0.0833
p.S512T	DO228883	LICA	ICGC	IAITPEPE	DEG_SCF_FBW7_2	0.25
p.V532G	SIDM00232	Kidney Carcinoma	GDSC	IAITPEPE	DEG_SCF_FBW7_2	0.0556
p.V532G	ACH-002168	Kidney Cancer	CCLE	IAITPEPE	DEG_SCF_FBW7_2	0.0556
p.A516D	ACH-001518	Endometrial/Uterine Cancer	CCLE	IAITPEPE	DEG_SCF_FBW7_2	0.6682

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q8N3K9	Cardiomyopathy-associated protein 5	DEG_SCF_FBW7_2	515:522	IAITPEPE	FBXW7	0.9418	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons