DegronMD

Uniprot ID: Q8N3K9

Source protein: Cardiomyopathy-associated protein 5

Source gene: CMYA5

Class: DEG_APCC_KENBOX_2

Location: 3016:3020

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.9733

ASA_SCORE: 127.92

COIL: 0.8678

CONS_SCORE: 0.6198

DSS_SCORE: 0.5914

HELIX: 0.1142

FCONS_SCORE: 1.3189

RIG_SCORE: 0.6895

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.K3012N	TCGA-D9-A6EC	SKCM	TCGA	LKENK	DEG_APCC_KENBOX_2	0.3333
p.K3012N	DO50291	SKCM	ICGC	LKENK	DEG_APCC_KENBOX_2	0.3333
p.S3006N	DO224559	LAML	ICGC	LKENK	DEG_APCC_KENBOX_2	0.0556
p.H3025D	SIDM01070	Non-Small Cell Lung Carcinoma	GDSC	LKENK	DEG_APCC_KENBOX_2	0.1944
p.H3025D	ACH-000840	Lung Cancer	CCLE	LKENK	DEG_APCC_KENBOX_2	0.1944
p.H3025D	HCC-366	lung	COSMIC	LKENK	DEG_APCC_KENBOX_2	0.1944
p.E3030D	SIDM00193	Colorectal Carcinoma	GDSC	LKENK	DEG_APCC_KENBOX_2	0.0556
p.E3030D	ACH-000991	Colon/Colorectal Cancer	CCLE	LKENK	DEG_APCC_KENBOX_2	0.0556
p.E3030D	SNU-81	large_intestine	COSMIC	LKENK	DEG_APCC_KENBOX_2	0.0556
p.K3012Q	SIDM01510	Non-Small Cell Lung Carcinoma	GDSC	LKENK	DEG_APCC_KENBOX_2	0.3333
p.K3012Q	ACH-000925	Lung Cancer	CCLE	LKENK	DEG_APCC_KENBOX_2	0.3333
p.T3024A	ACH-001610	Brain Cancer	CCLE	LKENK	DEG_APCC_KENBOX_2	0.2222
p.N3019S	ACH-001692	Head and Neck Cancer	CCLE	LKENK	DEG_APCC_KENBOX_2	0.7069

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q12888	TP53-binding protein 1	DEG_APCC_KENBOX_2	84:88	LKENK	APC,CDC20,FZR1	0.9912	More...
Q8N3K9	Cardiomyopathy-associated protein 5	DEG_APCC_KENBOX_2	3016:3020	LKENK	APC,CDC20,FZR1	0.9733	More...
Q96J02	E3 ubiquitin-protein ligase Itchy homolog	DEG_APCC_KENBOX_2	29:33	LKENK	APC,CDC20,FZR1	0.5521	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons