DegronMD

Uniprot ID: Q12888

Source protein: TP53-binding protein 1

Source gene: TP53BP1

Class: DEG_APCC_KENBOX_2

Location: 84:88

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.9912

ASA_SCORE: 118.88

COIL: 0.7578

CONS_SCORE: 0.2965

DSS_SCORE: 0.6096

HELIX: 0.2022

FCONS_SCORE: 0.994

RIG_SCORE: 0.7213

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.R78Q	TCGA-C8-A8HP	BRCA	TCGA	LKENK	DEG_APCC_KENBOX_2	0.6111
p.S83I	TCGA-DF-A2KU	UCEC	TCGA	LKENK	DEG_APCC_KENBOX_2	0.3056
p.A95S	TCGA-KQ-A41S	BLCA	TCGA	LKENK	DEG_APCC_KENBOX_2	0.1389
p.A90S	DO223593	BLCA	ICGC	LKENK	DEG_APCC_KENBOX_2	0.2778
p.S95Y	DO229018	LICA	ICGC	LKENK	DEG_APCC_KENBOX_2	0.1389
p.N97K	DO229031	LICA	ICGC	LKENK	DEG_APCC_KENBOX_2	0.0833
p.D91E	DO229035	LICA	ICGC	LKENK	DEG_APCC_KENBOX_2	0.25
p.P92T	DO229009	LICA	ICGC	LKENK	DEG_APCC_KENBOX_2	0.2222
p.S78I	DO223286	UCEC	ICGC	LKENK	DEG_APCC_KENBOX_2	0.6111

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q12888	TP53-binding protein 1	DEG_APCC_KENBOX_2	84:88	LKENK	APC,CDC20,FZR1	0.9912	More...
Q8N3K9	Cardiomyopathy-associated protein 5	DEG_APCC_KENBOX_2	3016:3020	LKENK	APC,CDC20,FZR1	0.9733	More...
Q96J02	E3 ubiquitin-protein ligase Itchy homolog	DEG_APCC_KENBOX_2	29:33	LKENK	APC,CDC20,FZR1	0.5521	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons