DegronMD

Uniprot ID: Q96J02

Source protein: E3 ubiquitin-protein ligase Itchy homolog

Source gene: ITCH

Class: DEG_APCC_KENBOX_2

Location: 29:33

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.5521

ASA_SCORE: 89.08

COIL: 0.7148

CONS_SCORE: 0.4471

DSS_SCORE: 0.3068

HELIX: 0.134

FCONS_SCORE: 0.9372

RIG_SCORE: 0.773

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.V43I	TCGA-A5-A1OF	UCEC	TCGA	LKENK	DEG_APCC_KENBOX_2	0.0556
p.V43I	DO42568	UCEC	ICGC	LKENK	DEG_APCC_KENBOX_2	0.0556
p.Q21E	TCGA-XF-A9SZ	BLCA	TCGA	LKENK	DEG_APCC_KENBOX_2	0.1111
p.Q21E	DO51919	BLCA	ICGC	LKENK	DEG_APCC_KENBOX_2	0.1111
p.V43L	DO228985	LICA	ICGC	LKENK	DEG_APCC_KENBOX_2	0.0556
p.P41L	SIDM01105	Melanoma	GDSC	LKENK	DEG_APCC_KENBOX_2	0.1111
p.P41L	SK-MEL-3	skin	COSMIC	LKENK	DEG_APCC_KENBOX_2	0.1111
p.K33M	ACH-001061	Colon/Colorectal Cancer	CCLE	LKENK	DEG_APCC_KENBOX_2	0.6951

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q12888	TP53-binding protein 1	DEG_APCC_KENBOX_2	84:88	LKENK	APC,CDC20,FZR1	0.9912	More...
Q8N3K9	Cardiomyopathy-associated protein 5	DEG_APCC_KENBOX_2	3016:3020	LKENK	APC,CDC20,FZR1	0.9733	More...
Q96J02	E3 ubiquitin-protein ligase Itchy homolog	DEG_APCC_KENBOX_2	29:33	LKENK	APC,CDC20,FZR1	0.5521	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons