DegronMD: protein-targeted degradation, mutation and drug response to degrons
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Degron:
DSTSASEYSVPSL
Uniprot ID:
Q8N3K9
Source protein:
Cardiomyopathy-associated protein 5
Source gene:
CMYA5
Class:
DEG_COP1_1
Location:
693:705
E3 ligase:
COP1
DEGRON score:
0.8745
ASA_SCORE:
88.9154
COIL:
0.9073
CONS_SCORE:
0.3971
DSS_SCORE:
0.4415
HELIX:
0.0319
FCONS_SCORE:
1.1953
RIG_SCORE:
0.6998
Degron related mutations and impact score
Mutation
Sample
Cancer
Dataset
Degron
Degron class
Impact score
p.P703S
TCGA-06-5416
GBM
TCGA
DSTSASEYSVPSL
DEG_COP1_1
0.6752
p.P703S
DO10880
GBM
ICGC
DSTSASEYSVPSL
DEG_COP1_1
0.6752
p.E709Q
TCGA-AA-3511
COAD
TCGA
DSTSASEYSVPSL
DEG_COP1_1
0.2222
p.E709Q
DO7804
COAD
ICGC
DSTSASEYSVPSL
DEG_COP1_1
0.2222
p.K712N
TCGA-AA-3984
COAD
TCGA
DSTSASEYSVPSL
DEG_COP1_1
0.25
p.K712N
DO9002
COAD
ICGC
DSTSASEYSVPSL
DEG_COP1_1
0.25
p.A697T
SIDM02055
Colorectal Carcinoma
GDSC
DSTSASEYSVPSL
DEG_COP1_1
0.6028
p.E709D
SIDM00980
Gastric Carcinoma
GDSC
DSTSASEYSVPSL
DEG_COP1_1
0.2222
p.E709D
ACH-000948
Gastric Cancer
CCLE
DSTSASEYSVPSL
DEG_COP1_1
0.2222
p.E709D
23132-87
stomach
COSMIC
DSTSASEYSVPSL
DEG_COP1_1
0.2222
p.S687R
SIDM01503
Small Cell Lung Carcinoma
GDSC
DSTSASEYSVPSL
DEG_COP1_1
0.6111
Drug responses associated with CMYA5 mutations
Sample
Cancer
Mutation (In Degron?)
Dataset
Drug
IC50
All proteins holding degron of DSTSASEYSVPSL
Uniprot ID
Source protein
Degron class
Location
Hit
E3 ligase
Degron score
Detail
Q8N3K9
Cardiomyopathy-associated protein 5
DEG_COP1_1
693:705
DSTSASEYSVPSL
COP1
0.8745
More...