DegronMD

Uniprot ID: Q8N3K9

Source protein: Cardiomyopathy-associated protein 5

Source gene: CMYA5

Class: DEG_SCF_FBW7_2

Location: 3013:3018

E3 ligase: FBXW7

DEGRON score: 0.9796

ASA_SCORE: 106.4667

COIL: 0.9017

CONS_SCORE: 0.5784

DSS_SCORE: 0.5666

HELIX: 0.0512

FCONS_SCORE: 1.249

RIG_SCORE: 0.719

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.K3005N	TCGA-EO-A3B0	UCEC	TCGA	VTPLKE	DEG_SCF_FBW7_2	0.2222
p.K3005N	DO219773	UCEC	ICGC	VTPLKE	DEG_SCF_FBW7_2	0.2222
p.S3006N	DO224559	LAML	ICGC	VTPLKE	DEG_SCF_FBW7_2	0.1389
p.H3025D	SIDM01070	Non-Small Cell Lung Carcinoma	GDSC	VTPLKE	DEG_SCF_FBW7_2	0.1389
p.H3025D	ACH-000840	Lung Cancer	CCLE	VTPLKE	DEG_SCF_FBW7_2	0.1389
p.H3025D	HCC-366	lung	COSMIC	VTPLKE	DEG_SCF_FBW7_2	0.1389
p.K3005E	SIDM00285	Neuroblastoma	GDSC	VTPLKE	DEG_SCF_FBW7_2	0.2222
p.K3005E	ACH-001338	Neuroblastoma	CCLE	VTPLKE	DEG_SCF_FBW7_2	0.2222
p.K3005E	CHP-134	autonomic_ganglia	COSMIC	VTPLKE	DEG_SCF_FBW7_2	0.2222
p.T3024A	ACH-001610	Brain Cancer	CCLE	VTPLKE	DEG_SCF_FBW7_2	0.1667

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q8N3K9	Cardiomyopathy-associated protein 5	DEG_SCF_FBW7_2	3013:3018	VTPLKE	FBXW7	0.9796	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons