DegronMD

Uniprot ID: Q8N3K9

Source protein: Cardiomyopathy-associated protein 5

Source gene: CMYA5

Class: DEG_APCC_DBOX_1

Location: 1384:1392

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.9029

ASA_SCORE: 96.9111

COIL: 0.8909

CONS_SCORE: 0.4565

DSS_SCORE: 0.43

HELIX: 0.018

FCONS_SCORE: 0.9565

RIG_SCORE: 0.7835

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.P1374T	TCGA-D3-A1Q3	SKCM	TCGA	DRPVLTKVG	DEG_APCC_DBOX_1	0.0556
p.P1374T	DO47509	SKCM	ICGC	DRPVLTKVG	DEG_APCC_DBOX_1	0.0556
p.S1378F	TCGA-EE-A29D	SKCM	TCGA	DRPVLTKVG	DEG_APCC_DBOX_1	0.1667
p.S1378F	TCGA-FW-A3R5	SKCM	TCGA	DRPVLTKVG	DEG_APCC_DBOX_1	0.1667
p.S1378F	DO37406	SKCM	ICGC	DRPVLTKVG	DEG_APCC_DBOX_1	0.1667
p.S1378F	DO38123	SKCM	ICGC	DRPVLTKVG	DEG_APCC_DBOX_1	0.1667
p.S1377L	TCGA-FR-A729	SKCM	TCGA	DRPVLTKVG	DEG_APCC_DBOX_1	0.1389
p.S1377L	DO48618	SKCM	ICGC	DRPVLTKVG	DEG_APCC_DBOX_1	0.1389
p.R1385C	TCGA-FS-A1ZW	SKCM	TCGA	DRPVLTKVG	DEG_APCC_DBOX_1	0.8301
p.R1385C	TCGA-XK-AAIW	PRAD	TCGA	DRPVLTKVG	DEG_APCC_DBOX_1	0.8301
p.R1385C	DO51407	PRAD	ICGC	DRPVLTKVG	DEG_APCC_DBOX_1	0.8301
p.R1385C	DO37519	SKCM	ICGC	DRPVLTKVG	DEG_APCC_DBOX_1	0.8301
p.T1389P	DO229183	NKTL	ICGC	DRPVLTKVG	DEG_APCC_DBOX_1	0.5919
p.P1374S	SIDM01184	Bladder Carcinoma	GDSC	DRPVLTKVG	DEG_APCC_DBOX_1	0.0556
p.P1374S	ACH-000018	Bladder Cancer	CCLE	DRPVLTKVG	DEG_APCC_DBOX_1	0.0556
p.P1374S	T-24	urinary_tract	COSMIC	DRPVLTKVG	DEG_APCC_DBOX_1	0.0556
p.D1384E	SIDM01045	Endometrial Carcinoma	GDSC	DRPVLTKVG	DEG_APCC_DBOX_1	0.5647
p.D1384E	ACH-000978	Endometrial/Uterine Cancer	CCLE	DRPVLTKVG	DEG_APCC_DBOX_1	0.5647
p.D1384E	EN	endometrium	COSMIC	DRPVLTKVG	DEG_APCC_DBOX_1	0.5647

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q8N3K9	Cardiomyopathy-associated protein 5	DEG_APCC_DBOX_1	1384:1392	DRPVLTKVG	APC,CDC20,FZR1	0.9029	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons