DegronMD

Uniprot ID: P48681

Source protein: Nestin

Source gene: NES

Class: DEG_APCC_KENBOX_2

Location: 671:675

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.5502

ASA_SCORE: 117.86

COIL: 0.4804

CONS_SCORE: 0.2961

DSS_SCORE: 0.6277

HELIX: 0.515

FCONS_SCORE: 0.7602

RIG_SCORE: 0.6756

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.S680Y	TCGA-06-5416	GBM	TCGA	EKENQ	DEG_APCC_KENBOX_2	0.6389
p.S680Y	TCGA-D1-A17Q	UCEC	TCGA	EKENQ	DEG_APCC_KENBOX_2	0.6389
p.S680Y	DO10880	GBM	ICGC	EKENQ	DEG_APCC_KENBOX_2	0.6389
p.S680Y	DO41903	UCEC	ICGC	EKENQ	DEG_APCC_KENBOX_2	0.6389
p.N674H	TCGA-AX-A05Z	UCEC	TCGA	EKENQ	DEG_APCC_KENBOX_2	0.7423
p.N674H	DO40884	UCEC	ICGC	EKENQ	DEG_APCC_KENBOX_2	0.7423
p.E662D	TCGA-AX-A05Z	UCEC	TCGA	EKENQ	DEG_APCC_KENBOX_2	0.0833
p.E662D	TCGA-B5-A0JY	UCEC	TCGA	EKENQ	DEG_APCC_KENBOX_2	0.0833
p.E662D	TCGA-CA-6717	COAD	TCGA	EKENQ	DEG_APCC_KENBOX_2	0.0833
p.E662D	DO8264	COAD	ICGC	EKENQ	DEG_APCC_KENBOX_2	0.0833
p.E662D	DO40884	UCEC	ICGC	EKENQ	DEG_APCC_KENBOX_2	0.0833
p.E662D	DO43041	UCEC	ICGC	EKENQ	DEG_APCC_KENBOX_2	0.0833
p.E662D	SIDM00118	Colorectal Carcinoma	GDSC	EKENQ	DEG_APCC_KENBOX_2	0.0833
p.E662D	ACH-001081	Colon/Colorectal Cancer	CCLE	EKENQ	DEG_APCC_KENBOX_2	0.0833
p.E662D	HCC2998	large_intestine	COSMIC	EKENQ	DEG_APCC_KENBOX_2	0.0833
p.R679I	TCGA-EO-A3AY	UCEC	TCGA	EKENQ	DEG_APCC_KENBOX_2	0.2222
p.R679I	DO43202	UCEC	ICGC	EKENQ	DEG_APCC_KENBOX_2	0.2222
p.S666L	TCGA-QC-A7B5	SARC	TCGA	EKENQ	DEG_APCC_KENBOX_2	0.1944
p.S666L	DO220239	SARC	ICGC	EKENQ	DEG_APCC_KENBOX_2	0.1944
p.L667F	DO225005	BRCA	ICGC	EKENQ	DEG_APCC_KENBOX_2	0.2222

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P30519	Heme oxygenase 2	DEG_APCC_KENBOX_2	23:27	EKENQ	APC,CDC20,FZR1	0.713	More...
P48681	Nestin	DEG_APCC_KENBOX_2	671:675	EKENQ	APC,CDC20,FZR1	0.5502	More...
P48681	Nestin	DEG_APCC_KENBOX_2	715:719	EKENQ	APC,CDC20,FZR1	0.9987	More...
Q15004	PCNA-associated factor	DEG_APCC_KENBOX_2	77:81	EKENQ	APC,CDC20,FZR1	0.9907	More...
Q16363	Laminin subunit alpha-4	DEG_APCC_KENBOX_2	358:362	EKENQ	APC,CDC20,FZR1	0.7882	More...
Q5TD94	Radial spoke head protein 4 homolog A	DEG_APCC_KENBOX_2	10:14	EKENQ	APC,CDC20,FZR1	0.9404	More...
Q8N3K9	Cardiomyopathy-associated protein 5	DEG_APCC_KENBOX_2	2540:2544	EKENQ	APC,CDC20,FZR1	0.8952	More...
Q9BXT5	Testis-expressed protein 15	DEG_APCC_KENBOX_2	1186:1190	EKENQ	APC,CDC20,FZR1	0.993	More...
Q9P219	Protein Daple	DEG_APCC_KENBOX_2	469:473	EKENQ	APC,CDC20,FZR1	0.7725	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons