DegronMD

Uniprot ID: P30519

Source protein: Heme oxygenase 2

Source gene: HMOX2

Class: DEG_APCC_KENBOX_2

Location: 23:27

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.713

ASA_SCORE: 112.3

COIL: 0.4802

CONS_SCORE: 0.3089

DSS_SCORE: 0.5905

HELIX: 0.4952

FCONS_SCORE: 0.7475

RIG_SCORE: 0.7218

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.K16N	TCGA-06-1802	GBM	TCGA	EKENQ	DEG_APCC_KENBOX_2	0.25
p.K16N	DO12100	GBM	ICGC	EKENQ	DEG_APCC_KENBOX_2	0.25
p.K17N	TCGA-AA-3977	COAD	TCGA	EKENQ	DEG_APCC_KENBOX_2	0.2778
p.K17N	TCGA-EO-A22X	UCEC	TCGA	EKENQ	DEG_APCC_KENBOX_2	0.2778
p.K17N	DO8730	COAD	ICGC	EKENQ	DEG_APCC_KENBOX_2	0.2778
p.K17N	DO43907	UCEC	ICGC	EKENQ	DEG_APCC_KENBOX_2	0.2778
p.S19P	TCGA-AP-A051	UCEC	TCGA	EKENQ	DEG_APCC_KENBOX_2	0.2222
p.S19P	DO42673	UCEC	ICGC	EKENQ	DEG_APCC_KENBOX_2	0.2222
p.N18S	TCGA-AP-A054	UCEC	TCGA	EKENQ	DEG_APCC_KENBOX_2	0.1944
p.N18S	DO42256	UCEC	ICGC	EKENQ	DEG_APCC_KENBOX_2	0.1944
p.E13K	TCGA-D1-A103	UCEC	TCGA	EKENQ	DEG_APCC_KENBOX_2	0.0556
p.E13K	DO42312	UCEC	ICGC	EKENQ	DEG_APCC_KENBOX_2	0.0556
p.E23Q	DO224847	BRCA	ICGC	EKENQ	DEG_APCC_KENBOX_2	0.5633
p.E23Q	DO227473	BRCA	ICGC	EKENQ	DEG_APCC_KENBOX_2	0.5633
p.G20W	DO227802	COCA	ICGC	EKENQ	DEG_APCC_KENBOX_2	0.25
p.E20K	DO41235	UCEC	ICGC	EKENQ	DEG_APCC_KENBOX_2	0.25
p.E13G	ACH-000957	Colon/Colorectal Cancer	CCLE	EKENQ	DEG_APCC_KENBOX_2	0.0556
p.E13G	LS-180	large_intestine	COSMIC	EKENQ	DEG_APCC_KENBOX_2	0.0556
p.L36V	ACH-002117	Bone Cancer	CCLE	EKENQ	DEG_APCC_KENBOX_2	0.0833
p.L36V	EW-24	bone	COSMIC	EKENQ	DEG_APCC_KENBOX_2	0.0833

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P30519	Heme oxygenase 2	DEG_APCC_KENBOX_2	23:27	EKENQ	APC,CDC20,FZR1	0.713	More...
P48681	Nestin	DEG_APCC_KENBOX_2	671:675	EKENQ	APC,CDC20,FZR1	0.5502	More...
P48681	Nestin	DEG_APCC_KENBOX_2	715:719	EKENQ	APC,CDC20,FZR1	0.9987	More...
Q15004	PCNA-associated factor	DEG_APCC_KENBOX_2	77:81	EKENQ	APC,CDC20,FZR1	0.9907	More...
Q16363	Laminin subunit alpha-4	DEG_APCC_KENBOX_2	358:362	EKENQ	APC,CDC20,FZR1	0.7882	More...
Q5TD94	Radial spoke head protein 4 homolog A	DEG_APCC_KENBOX_2	10:14	EKENQ	APC,CDC20,FZR1	0.9404	More...
Q8N3K9	Cardiomyopathy-associated protein 5	DEG_APCC_KENBOX_2	2540:2544	EKENQ	APC,CDC20,FZR1	0.8952	More...
Q9BXT5	Testis-expressed protein 15	DEG_APCC_KENBOX_2	1186:1190	EKENQ	APC,CDC20,FZR1	0.993	More...
Q9P219	Protein Daple	DEG_APCC_KENBOX_2	469:473	EKENQ	APC,CDC20,FZR1	0.7725	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons