PCLAF
UniProt ID: Q15004
Entrez ID: 9768
Protein name: PCNA-associated factor (Hepatitis C virus NS5A-transactivated protein 9) (HCV NS5A-transactivated protein 9) (Overexpressed in anaplastic thyroid carcinoma 1) (OEATC-1) (PCNA-associated factor of 15 kDa) (PAF15) (p15PAF) (PCNA-clamp-associated factor)
External links: UniprotKB HGNC RefSeq COSMIC
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FUNCTION: PCNA-binding protein that acts as a regulator of DNA repair during DNA replication. Following DNA damage, the interaction with PCNA is disrupted, facilitating the interaction between monoubiquitinated PCNA and the translesion DNA synthesis DNA polymerase eta (POLH) at stalled replisomes, f...
FUNCTION: PCNA-binding protein that acts as a regulator of DNA repair during DNA replication. Following DNA damage, the interaction with PCNA is disrupted, facilitating the interaction between monoubiquitinated PCNA and the translesion DNA synthesis DNA polymerase eta (POLH) at stalled replisomes, facilitating the bypass of replication-fork-blocking lesions. Also acts as a regulator of centrosome number. {ECO:0000269|PubMed:21673012, ECO:0000269|PubMed:23000965}.
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GO - Biological processes (BP):
cellular response to DNA damage stimulus [GO:0006974]; centrosome cycle [GO:0007098]; DNA replication [GO:0006260]; regulation of cell cycle [GO:0051726]; response to UV [GO:0009411]; translesion synthesis [GO:0019985]...
cellular response to DNA damage stimulus [GO:0006974]; centrosome cycle [GO:0007098]; DNA replication [GO:0006260]; regulation of cell cycle [GO:0051726]; response to UV [GO:0009411]; translesion synthesis [GO:0019985]
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GO - Molecular function (MF):
chromatin binding [GO:0003682]...
chromatin binding [GO:0003682]
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GO - Cellular component (CC):
centrosome [GO:0005813]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; perinuclear region of cytoplasm [GO:0048471]...
centrosome [GO:0005813]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; perinuclear region of cytoplasm [GO:0048471]
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PCLAF
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Kaplan plot for PCLAF in
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*NOTE: the Kaplan plots were collected from OncoLnc