DegronMD - P30519(HMOX2)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.K16N	TCGA-06-1802	GBM	TCGA	EKENQ	DEG_APCC_KENBOX_2	23:27	Mutation substituting flanking lysine	0.25
p.K16N	DO12100	GBM	ICGC	EKENQ	DEG_APCC_KENBOX_2	23:27	Mutation substituting flanking lysine	0.25
p.K17N	TCGA-AA-3977	COAD	TCGA	EKENQ	DEG_APCC_KENBOX_2	23:27	Mutation substituting flanking lysine	0.2778
p.K17N	TCGA-EO-A22X	UCEC	TCGA	EKENQ	DEG_APCC_KENBOX_2	23:27	Mutation substituting flanking lysine	0.2778
p.K17N	DO8730	COAD	ICGC	EKENQ	DEG_APCC_KENBOX_2	23:27	Mutation substituting flanking lysine	0.2778
p.K17N	DO43907	UCEC	ICGC	EKENQ	DEG_APCC_KENBOX_2	23:27	Mutation substituting flanking lysine	0.2778
p.S19P	TCGA-AP-A051	UCEC	TCGA	EKENQ	DEG_APCC_KENBOX_2	23:27	Mutation rewiring degron network	0.2222
p.S19P	DO42673	UCEC	ICGC	EKENQ	DEG_APCC_KENBOX_2	23:27	Mutation rewiring degron network	0.2222
p.N18S	TCGA-AP-A054	UCEC	TCGA	EKENQ	DEG_APCC_KENBOX_2	23:27	Mutation rewiring degron network	0.1944
p.N18S	DO42256	UCEC	ICGC	EKENQ	DEG_APCC_KENBOX_2	23:27	Mutation rewiring degron network	0.1944
p.E13K	TCGA-D1-A103	UCEC	TCGA	EKENQ	DEG_APCC_KENBOX_2	23:27	Mutation rewiring degron network	0.0556
p.E13K	DO42312	UCEC	ICGC	EKENQ	DEG_APCC_KENBOX_2	23:27	Mutation rewiring degron network	0.0556
p.E23Q	DO224847	BRCA	ICGC	EKENQ	DEG_APCC_KENBOX_2	23:27	Mutation altering degron motif	0.5633
p.E23Q	DO227473	BRCA	ICGC	EKENQ	DEG_APCC_KENBOX_2	23:27	Mutation altering degron motif	0.5633
p.G20W	DO227802	COCA	ICGC	EKENQ	DEG_APCC_KENBOX_2	23:27	Mutation rewiring degron network	0.25
p.E20K	DO41235	UCEC	ICGC	EKENQ	DEG_APCC_KENBOX_2	23:27	Mutation rewiring degron network	0.25
p.E13G	ACH-000957	Colon/Colorectal Cancer	CCLE	EKENQ	DEG_APCC_KENBOX_2	23:27	Mutation rewiring degron network	0.0556
p.E13G	LS-180	large intestine	COSMIC	EKENQ	DEG_APCC_KENBOX_2	23:27	Mutation rewiring degron network	0.0556
p.L36V	ACH-002117	Bone Cancer	CCLE	EKENQ	DEG_APCC_KENBOX_2	23:27	Mutation rewiring degron network	0.0833
p.L36V	EW-24	bone	COSMIC	EKENQ	DEG_APCC_KENBOX_2	23:27	Mutation rewiring degron network	0.0833

Kaplan plot for HMOX2 in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

HMOX2

UniProt ID: P30519

Entrez ID: 3163

Protein name: Heme oxygenase 2 (HO-2) (EC 1.14.14.18) [Cleaved into: Heme oxygenase 2 soluble form]

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for HMOX2 in