DegronMD

Uniprot ID: Q16363

Source protein: Laminin subunit alpha-4

Source gene: LAMA4

Class: DEG_SCF_FBW7_1

Location: 1720:1725

E3 ligase: FBXW7

DEGRON score: 0.9278

ASA_SCORE: 72.05

COIL: 0.717

CONS_SCORE: 0.4624

DSS_SCORE: 0.3275

HELIX: 0.0565

FCONS_SCORE: 0.9999

RIG_SCORE: 0.7947

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.L1726I	TCGA-A5-A1OF	UCEC	TCGA	VTPKQS	DEG_SCF_FBW7_1	0.3056
p.C1727R	TCGA-CU-A72E	BLCA	TCGA	VTPKQS	DEG_SCF_FBW7_1	0.2778
p.V1720F	TCGA-FS-A1ZR	SKCM	TCGA	VTPKQS	DEG_SCF_FBW7_1	0.7068
p.C1720R	DO49734	BLCA	ICGC	VTPKQS	DEG_SCF_FBW7_1	0.8301
p.H1725N	DO229025	LICA	ICGC	VTPKQS	DEG_SCF_FBW7_1	0.7423
p.T1714K	DO229036	LICA	ICGC	VTPKQS	DEG_SCF_FBW7_1	0.1667
p.V1713F	DO37651	SKCM	ICGC	VTPKQS	DEG_SCF_FBW7_1	0.1389
p.R1731I	DO37444	SKCM	ICGC	VTPKQS	DEG_SCF_FBW7_1	0.1667
p.L1719I	DO42568	UCEC	ICGC	VTPKQS	DEG_SCF_FBW7_1	0.3056

DegronMD: protein-targeted degradation, mutation and drug response to degrons