DegronMD

Uniprot ID: Q16787

Source protein: Laminin subunit alpha-3

Source gene: LAMA3

Class: DEG_SCF_FBW7_1

Location: 3230:3235

E3 ligase: FBXW7

DEGRON score: 0.5313

ASA_SCORE: 73.7833

COIL: 0.7793

CONS_SCORE: 0.3223

DSS_SCORE: 0.4374

HELIX: 0.0278

FCONS_SCORE: 0.8535

RIG_SCORE: 0.7414

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.S3229L	TCGA-86-8358	LUAD	TCGA	VTPKQS	DEG_SCF_FBW7_1	0.3056
p.S3229L	DO25471	LUAD	ICGC	VTPKQS	DEG_SCF_FBW7_1	0.3056
p.D3220N	TCGA-AA-3685	COAD	TCGA	VTPKQS	DEG_SCF_FBW7_1	0.0556
p.D3220N	DO8047	COAD	ICGC	VTPKQS	DEG_SCF_FBW7_1	0.0556
p.P3232A	TCGA-BR-8483	STAD	TCGA	VTPKQS	DEG_SCF_FBW7_1	0.7503
p.P3232A	DO47821	STAD	ICGC	VTPKQS	DEG_SCF_FBW7_1	0.7503
p.L3236M	TCGA-FS-A1Z0	SKCM	TCGA	VTPKQS	DEG_SCF_FBW7_1	0.3056
p.L3236M	DO37431	SKCM	ICGC	VTPKQS	DEG_SCF_FBW7_1	0.3056
p.T3233M	SJSA-1	bone	COSMIC	VTPKQS	DEG_SCF_FBW7_1	0.7423

DegronMD: protein-targeted degradation, mutation and drug response to degrons