DegronMD

Uniprot ID: Q9P219

Source protein: Protein Daple

Source gene: CCDC88C

Class: DEG_APCC_DBOX_1

Location: 799:807

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.7877

ASA_SCORE: 113.5222

COIL: 0.0288

CONS_SCORE: 0.4874

DSS_SCORE: 0.327

HELIX: 0.9723

FCONS_SCORE: 1.1888

RIG_SCORE: 0.8116

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.R807Q	TCGA-AJ-A2QO	UCEC	TCGA	LRRDLEALR	DEG_APCC_DBOX_1	0.6218
p.R807Q	DO42177	UCEC	ICGC	LRRDLEALR	DEG_APCC_DBOX_1	0.6218
p.A794V	TCGA-BR-8680	STAD	TCGA	LRRDLEALR	DEG_APCC_DBOX_1	0.1944
p.A794V	DO47769	STAD	ICGC	LRRDLEALR	DEG_APCC_DBOX_1	0.1944
p.R796C	TCGA-BR-A4QL	STAD	TCGA	LRRDLEALR	DEG_APCC_DBOX_1	0.25
p.R796C	DO38723	STAD	ICGC	LRRDLEALR	DEG_APCC_DBOX_1	0.25
p.A798V	TCGA-D1-A17U	UCEC	TCGA	LRRDLEALR	DEG_APCC_DBOX_1	0.3056
p.A798V	DO41887	UCEC	ICGC	LRRDLEALR	DEG_APCC_DBOX_1	0.3056
p.D802H	TCGA-MI-A75C	LIHC	TCGA	LRRDLEALR	DEG_APCC_DBOX_1	0.6577
p.D802H	DO49705	LIHC	ICGC	LRRDLEALR	DEG_APCC_DBOX_1	0.6577
p.G815R	DO228190	LICA	ICGC	LRRDLEALR	DEG_APCC_DBOX_1	0.1111
p.D802N	DO222749	MELA	ICGC	LRRDLEALR	DEG_APCC_DBOX_1	0.5821
p.L803V	DO32596	OV	ICGC	LRRDLEALR	DEG_APCC_DBOX_1	0.6765
p.R796H	SIDM02013	Colorectal Carcinoma	GDSC	LRRDLEALR	DEG_APCC_DBOX_1	0.25
p.R796H	ACH-001369	Ovarian Cancer	CCLE	LRRDLEALR	DEG_APCC_DBOX_1	0.25
p.A811E	SIDM00926	Non-Small Cell Lung Carcinoma	GDSC	LRRDLEALR	DEG_APCC_DBOX_1	0.2222
p.A811E	SIDM00845	Burkitt's Lymphoma	GDSC	LRRDLEALR	DEG_APCC_DBOX_1	0.2222
p.A811E	SIDM00967	Ovarian Carcinoma	GDSC	LRRDLEALR	DEG_APCC_DBOX_1	0.2222
p.A811E	SIDM00656	Burkitt's Lymphoma	GDSC	LRRDLEALR	DEG_APCC_DBOX_1	0.2222
p.A811E	SIDM00846	Cervical Carcinoma	GDSC	LRRDLEALR	DEG_APCC_DBOX_1	0.2222
p.A811E	SIDM00875	Breast Carcinoma	GDSC	LRRDLEALR	DEG_APCC_DBOX_1	0.2222
p.A811E	SIDM00844	Burkitt's Lymphoma	GDSC	LRRDLEALR	DEG_APCC_DBOX_1	0.2222
p.A811E	SIDM00032	Bladder Carcinoma	GDSC	LRRDLEALR	DEG_APCC_DBOX_1	0.2222
p.A811E	SIDM00793	Burkitt's Lymphoma	GDSC	LRRDLEALR	DEG_APCC_DBOX_1	0.2222
p.A811E	SIDM00863	Burkitt's Lymphoma	GDSC	LRRDLEALR	DEG_APCC_DBOX_1	0.2222
p.A811E	SIDM00641	Burkitt's Lymphoma	GDSC	LRRDLEALR	DEG_APCC_DBOX_1	0.2222
p.A811E	SIDM01525	Acute Myeloid Leukemia	GDSC	LRRDLEALR	DEG_APCC_DBOX_1	0.2222
p.A811V	SIDM00217	Colorectal Carcinoma	GDSC	LRRDLEALR	DEG_APCC_DBOX_1	0.2222
p.A811V	SNU-1040	large_intestine	COSMIC	LRRDLEALR	DEG_APCC_DBOX_1	0.2222

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: LRRDLEALR

Degron related mutations and impact score

Drug responses associated with CCDC88C mutations

All proteins holding degron of LRRDLEALR

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q9P219	Protein Daple	DEG_APCC_DBOX_1	799:807	LRRDLEALR	APC,CDC20,FZR1	0.7877	More...