DegronMD

Uniprot ID: Q3V6T2

Source protein: Girdin

Source gene: CCDC88A

Class: DEG_SCF_FBW7_1

Location: 1418:1425

E3 ligase: FBXW7

DEGRON score: 0.9915

ASA_SCORE: 107.6875

COIL: 0.8784

CONS_SCORE: 0.6813

DSS_SCORE: 0.612

HELIX: 0.0995

FCONS_SCORE: 0.988

RIG_SCORE: 0.6842

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.R1411L	TCGA-D3-A3CE	SKCM	TCGA	LTLTPTRS	DEG_SCF_FBW7_1	0.1389
p.R1411L	DO37405	SKCM	ICGC	LTLTPTRS	DEG_SCF_FBW7_1	0.1389
p.R1413H	DO233903	GACA	ICGC	LTLTPTRS	DEG_SCF_FBW7_1	0.1944
p.R1423S	DO229034	LICA	ICGC	LTLTPTRS	DEG_SCF_FBW7_1	0.7427
p.R1413C	DO229054	LICA	ICGC	LTLTPTRS	DEG_SCF_FBW7_1	0.1944
p.D1408G	DO28093	OV	ICGC	LTLTPTRS	DEG_SCF_FBW7_1	0.1667
p.R1411W	DO232761	PBCA	ICGC	LTLTPTRS	DEG_SCF_FBW7_1	0.1389
p.T1422A	SIDM00364	B-Lymphoblastic Leukemia	GDSC	LTLTPTRS	DEG_SCF_FBW7_1	0.7139
p.T1422A	P30-OHK	haematopoietic_and_lymphoid_tissue	COSMIC	LTLTPTRS	DEG_SCF_FBW7_1	0.7139
p.F1430C	SIDM00118	Colorectal Carcinoma	GDSC	LTLTPTRS	DEG_SCF_FBW7_1	0.1944
p.F1430C	HCC2998	large_intestine	COSMIC	LTLTPTRS	DEG_SCF_FBW7_1	0.1944
p.P1421R	SIDM01611	Endometrial Carcinoma	GDSC	LTLTPTRS	DEG_SCF_FBW7_1	0.7512
p.P1422R	ACH-000996	Endometrial/Uterine Cancer	CCLE	LTLTPTRS	DEG_SCF_FBW7_1	0.7512
p.F1431C	ACH-001081	Colon/Colorectal Cancer	CCLE	LTLTPTRS	DEG_SCF_FBW7_1	0.1667
p.F1431C	HCC2998	large_intestine	COSMIC	LTLTPTRS	DEG_SCF_FBW7_1	0.1667
p.S1417Y	ACH-001109	Rhabdoid	CCLE	LTLTPTRS	DEG_SCF_FBW7_1	0.75
p.T1423A	P30-OHK	haematopoietic_and_lymphoid_tissue	COSMIC	LTLTPTRS	DEG_SCF_FBW7_1	0.6028
p.V1429I	JSC-1	haematopoietic_and_lymphoid_tissue	COSMIC	LTLTPTRS	DEG_SCF_FBW7_1	0.2222

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q3V6T2	Girdin	DEG_SCF_FBW7_1	1418:1425	LTLTPTRS	FBXW7	0.9915	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons