DegronMD

Uniprot ID: Q3V6T2

Source protein: Girdin

Source gene: CCDC88A

Class: DEG_SCF_TRCP1_1

Location: 1589:1595

E3 ligase: BTRC

DEGRON score: 0.9886

ASA_SCORE: 92.0714

COIL: 0.9403

CONS_SCORE: 0.6695

DSS_SCORE: 0.6845

HELIX: 0.0366

FCONS_SCORE: 0.9949

RIG_SCORE: 0.571

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.D1588N	TCGA-17-Z026	LUAD	TCGA	DSGRTST	DEG_SCF_TRCP1_1	0.3056
p.G1590A	TCGA-D7-6528	STAD	TCGA	DSGRTST	DEG_SCF_TRCP1_1	0.754
p.G1590A	DO38547	STAD	ICGC	DSGRTST	DEG_SCF_TRCP1_1	0.754
p.R1591T	TCGA-DK-AA6L	BLCA	TCGA	DSGRTST	DEG_SCF_TRCP1_1	0.7876
p.R1591T	DO219002	BLCA	ICGC	DSGRTST	DEG_SCF_TRCP1_1	0.7876
p.S1597N	DO222946	BTCA	ICGC	DSGRTST	DEG_SCF_TRCP1_1	0.2778
p.T1594A	DO45213	LIRI	ICGC	DSGRTST	DEG_SCF_TRCP1_1	0.7139
p.V1579G	DO232761	PBCA	ICGC	DSGRTST	DEG_SCF_TRCP1_1	0.0556
p.Q1591H	ACH-000089	Colon/Colorectal Cancer	CCLE	DSGRTST	DEG_SCF_TRCP1_1	0.7582
p.V1584A	ACH-000698	Lung Cancer	CCLE	DSGRTST	DEG_SCF_TRCP1_1	0.1944
p.V1584A	DMS-53	lung	COSMIC	DSGRTST	DEG_SCF_TRCP1_1	0.1944
p.V1583A	DMS-53	lung	COSMIC	DSGRTST	DEG_SCF_TRCP1_1	0.6111

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q3V6T2	Girdin	DEG_SCF_TRCP1_1	1589:1595	DSGRTST	BTRC	0.9886	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons