DegronMD

Uniprot ID: Q3V6T2

Source protein: Girdin

Source gene: CCDC88A

Class: DEG_Kelch_Keap1_1

Location: 1620:1625

E3 ligase: KEAP1

DEGRON score: 0.9886

ASA_SCORE: 80.4167

COIL: 0.8485

CONS_SCORE: 0.659

DSS_SCORE: 0.628

HELIX: 0.1082

FCONS_SCORE: 0.9905

RIG_SCORE: 0.5854

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.H1631N	TCGA-78-7535	LUAD	TCGA	SHSSGE	DEG_Kelch_Keap1_1	0.1667
p.H1631N	DO24860	LUAD	ICGC	SHSSGE	DEG_Kelch_Keap1_1	0.1667
p.E1624D	TCGA-AP-A056	UCEC	TCGA	SHSSGE	DEG_Kelch_Keap1_1	0.6758
p.E1624D	DO43971	UCEC	ICGC	SHSSGE	DEG_Kelch_Keap1_1	0.6758
p.Q1614H	TCGA-DM-A0XD	COAD	TCGA	SHSSGE	DEG_Kelch_Keap1_1	0.1667
p.Q1614H	DO10228	COAD	ICGC	SHSSGE	DEG_Kelch_Keap1_1	0.1667
p.E1632D	TCGA-DU-6392	LGG	TCGA	SHSSGE	DEG_Kelch_Keap1_1	0.1389
p.E1632D	DO22237	LGG	ICGC	SHSSGE	DEG_Kelch_Keap1_1	0.1389
p.D1630G	TCGA-E6-A1LX	UCEC	TCGA	SHSSGE	DEG_Kelch_Keap1_1	0.1944
p.D1630G	DO41020	UCEC	ICGC	SHSSGE	DEG_Kelch_Keap1_1	0.1944
p.S1626G	TCGA-HE-7128	KIRP	TCGA	SHSSGE	DEG_Kelch_Keap1_1	0.3056
p.S1626G	DO20796	KIRP	ICGC	SHSSGE	DEG_Kelch_Keap1_1	0.3056
p.D1630E	DO229018	LICA	ICGC	SHSSGE	DEG_Kelch_Keap1_1	0.1944
p.N1613K	DO229022	LICA	ICGC	SHSSGE	DEG_Kelch_Keap1_1	0.1389
p.P1617Q	DO229035	LICA	ICGC	SHSSGE	DEG_Kelch_Keap1_1	0.25
p.S1626R	DO229009	LICA	ICGC	SHSSGE	DEG_Kelch_Keap1_1	0.3056
p.P1617L	DO33008	PACA	ICGC	SHSSGE	DEG_Kelch_Keap1_1	0.25
p.N1613I	SIDM00845	Burkitt's Lymphoma	GDSC	SHSSGE	DEG_Kelch_Keap1_1	0.1389
p.V1611A	SIDM00523	Small Cell Lung Carcinoma	GDSC	SHSSGE	DEG_Kelch_Keap1_1	0.0833
p.V1611A	DMS-53	lung	COSMIC	SHSSGE	DEG_Kelch_Keap1_1	0.0833
p.Q1618H	SIDM01665	Colorectal Carcinoma	GDSC	SHSSGE	DEG_Kelch_Keap1_1	0.2778
p.S1613T	ACH-000217	Liver Cancer	CCLE	SHSSGE	DEG_Kelch_Keap1_1	0.1389
p.S1613T	ACH-001495	Endometrial/Uterine Cancer	CCLE	SHSSGE	DEG_Kelch_Keap1_1	0.1389
p.S1613T	JHH-6	liver	COSMIC	SHSSGE	DEG_Kelch_Keap1_1	0.1389
p.V1612A	DMS-53	lung	COSMIC	SHSSGE	DEG_Kelch_Keap1_1	0.1111
p.S1612T	JHH-6	liver	COSMIC	SHSSGE	DEG_Kelch_Keap1_1	0.1111

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q3V6T2	Girdin	DEG_Kelch_Keap1_1	1620:1625	SHSSGE	KEAP1	0.9886	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: SHSSGE

Degron related mutations and impact score

Drug responses associated with CCDC88A mutations

All proteins holding degron of SHSSGE