DegronMD - Q9HCE9(ANO8)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.E933K	TCGA-4Z-AA84	BLCA	TCGA	PATSS	DEG_SPOP_SBC_1	939:943	Mutation rewiring degron network	0.1667
p.E933K	DO218988	BLCA	ICGC	PATSS	DEG_SPOP_SBC_1	939:943	Mutation rewiring degron network	0.1667
p.E933K	SIDM01318	Hepatocellular Carcinoma	GDSC	PATSS	DEG_SPOP_SBC_1	939:943	Mutation rewiring degron network	0.1667
p.E933K	ACH-001318	Liver Cancer	CCLE	PATSS	DEG_SPOP_SBC_1	939:943	Mutation rewiring degron network	0.1667
p.T941A	TCGA-AP-A054	UCEC	TCGA	PATSS	DEG_SPOP_SBC_1	939:943	Mutation altering degron motif	0.825
p.T941A	DO42256	UCEC	ICGC	PATSS	DEG_SPOP_SBC_1	939:943	Mutation altering degron motif	0.825
p.A940V	TCGA-AP-A1DK	UCEC	TCGA	PATSS	DEG_SPOP_SBC_1	939:943	Mutation altering degron motif	0.5825
p.A940V	DO42033	UCEC	ICGC	PATSS	DEG_SPOP_SBC_1	939:943	Mutation altering degron motif	0.5825
p.A930V	TCGA-BG-A18B	UCEC	TCGA	PATSS	DEG_SPOP_SBC_1	939:943	Mutation rewiring degron network	0.0833
p.A930V	DO41452	UCEC	ICGC	PATSS	DEG_SPOP_SBC_1	939:943	Mutation rewiring degron network	0.0833
p.A930V	SIDM00946	T-Lymphoblastic Leukemia	GDSC	PATSS	DEG_SPOP_SBC_1	939:943	Mutation rewiring degron network	0.0833
p.A930V	ACH-000981	Leukemia	CCLE	PATSS	DEG_SPOP_SBC_1	939:943	Mutation rewiring degron network	0.0833
p.A930V	DND-41	haematopoietic and lymphoid tissue	COSMIC	PATSS	DEG_SPOP_SBC_1	939:943	Mutation rewiring degron network	0.0833
p.P1222T	TCGA-CR-7385	HNSC	TCGA	PLETPAPS	DEG_SCF_FBW7_1	1208:1215	Mutation rewiring degron network	0.1389
p.P1222T	DO14282	HNSC	ICGC	PLETPAPS	DEG_SCF_FBW7_1	1208:1215	Mutation rewiring degron network	0.1389
p.E933D	TCGA-EE-A29P	SKCM	TCGA	PATSS	DEG_SPOP_SBC_1	939:943	Mutation rewiring degron network	0.1667
p.E933D	DO37916	SKCM	ICGC	PATSS	DEG_SPOP_SBC_1	939:943	Mutation rewiring degron network	0.1667
p.P1220H	DO233273	GACA	ICGC	PLETPAPS	DEG_SCF_FBW7_1	1208:1215	Mutation rewiring degron network	0.1944
p.A948D	DO228971	LICA	ICGC	PATSS	DEG_SPOP_SBC_1	939:943	Mutation rewiring degron network	0.1944
p.Q1186P	DO27636	LUSC	ICGC	DASFYSLPP	CBL_PTK	1191:1199	Mutation rewiring degron network	0.1944
p.A940T	DO229268	THCA	ICGC	PATSS	DEG_SPOP_SBC_1	939:943	Mutation altering degron motif	0.6028
p.D1207N	SIDM00879	Breast Carcinoma	GDSC	PLETPAPS	DEG_SCF_FBW7_1	1208:1215	Mutation rewiring degron network	0.3056
p.D1207N	SIDM00879	Breast Carcinoma	GDSC	DASFYSLPP	CBL_PTK	1191:1199	Mutation rewiring degron network	0.1111
p.D1207N	HCC1500	breast	COSMIC	PLETPAPS	DEG_SCF_FBW7_1	1208:1215	Mutation rewiring degron network	0.3056
p.D1207N	HCC1500	breast	COSMIC	DASFYSLPP	CBL_PTK	1191:1199	Mutation rewiring degron network	0.1111
p.G936W	SIDM01609	Endometrial Carcinoma	GDSC	PATSS	DEG_SPOP_SBC_1	939:943	Mutation rewiring degron network	0.25
p.G936W	ACH-000972	Endometrial/Uterine Cancer	CCLE	PATSS	DEG_SPOP_SBC_1	939:943	Mutation rewiring degron network	0.25
p.P1187T	ACH-000573	Breast Cancer	CCLE	DASFYSLPP	CBL_PTK	1191:1199	Mutation rewiring degron network	0.2222

Kaplan plot for ANO8 in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

ANO8

UniProt ID: Q9HCE9

Entrez ID: 57719

Protein name: Anoctamin-8 (Transmembrane protein 16H)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for ANO8 in