DegronMD: protein-targeted degradation, mutation and drug response to degrons
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BSML
CPH
CGC
Degron:
DASFYSLPP
Uniprot ID:
Q9HCE9
Source protein:
Anoctamin-8
Source gene:
ANO8
Class:
CBL_PTK
Location:
1191:1199
E3 ligase:
CBL
DEGRON score:
0.8703
ASA_SCORE:
67.2667
COIL:
0.7572
CONS_SCORE:
0.2063
DSS_SCORE:
0.6759
HELIX:
0.1643
FCONS_SCORE:
1.0162
RIG_SCORE:
0.5758
Degron related mutations and impact score
Mutation
Sample
Cancer
Dataset
Degron
Degron class
Impact score
p.Q1186P
DO27636
LUSC
ICGC
DASFYSLPP
CBL_PTK
0.1944
p.D1207N
SIDM00879
Breast Carcinoma
GDSC
DASFYSLPP
CBL_PTK
0.1111
p.D1207N
HCC1500
breast
COSMIC
DASFYSLPP
CBL_PTK
0.1111
p.P1187T
ACH-000573
Breast Cancer
CCLE
DASFYSLPP
CBL_PTK
0.2222
Drug responses associated with ANO8 mutations
Sample
Cancer
Mutation (In Degron?)
Dataset
Drug
IC50
All proteins holding degron of DASFYSLPP
Uniprot ID
Source protein
Degron class
Location
Hit
E3 ligase
Degron score
Detail
Q9HCE9
Anoctamin-8
CBL_PTK
1191:1199
DASFYSLPP
CBL
0.8703
More...
