DegronMD

Uniprot ID: Q9HCE9

Source protein: Anoctamin-8

Source gene: ANO8

Class: DEG_SCF_FBW7_1

Location: 1208:1215

E3 ligase: FBXW7

DEGRON score: 0.823

ASA_SCORE: 87.4

COIL: 0.9568

CONS_SCORE: 0.2025

DSS_SCORE: 0.7466

HELIX: 0.0158

FCONS_SCORE: 0.993

RIG_SCORE: 0.5458

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.P1222T	TCGA-CR-7385	HNSC	TCGA	PLETPAPS	DEG_SCF_FBW7_1	0.1389
p.P1222T	DO14282	HNSC	ICGC	PLETPAPS	DEG_SCF_FBW7_1	0.1389
p.P1220H	DO233273	GACA	ICGC	PLETPAPS	DEG_SCF_FBW7_1	0.1944
p.D1207N	SIDM00879	Breast Carcinoma	GDSC	PLETPAPS	DEG_SCF_FBW7_1	0.3056
p.D1207N	HCC1500	breast	COSMIC	PLETPAPS	DEG_SCF_FBW7_1	0.3056

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q9HCE9	Anoctamin-8	DEG_SCF_FBW7_1	1208:1215	PLETPAPS	FBXW7	0.823	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons