DegronMD

Uniprot ID: Q96HA1

Source protein: Nuclear envelope pore membrane protein POM 121

Source gene: POM121

Class: DEG_SPOP_SBC_1

Location: 930:934

E3 ligase: SPOP

DEGRON score: 0.9895

ASA_SCORE: 74.7

COIL: 0.9354

CONS_SCORE: 0.7251

DSS_SCORE: 0.4336

HELIX: 0.0278

FCONS_SCORE: 1.17

RIG_SCORE: 0.6543

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.T922I	TCGA-AP-A059	UCEC	TCGA	PATSS	DEG_SPOP_SBC_1	0.1111
p.T922I	DO41361	UCEC	ICGC	PATSS	DEG_SPOP_SBC_1	0.1111
p.P923H	TCGA-BR-4256	STAD	TCGA	PATSS	DEG_SPOP_SBC_1	0.1389
p.G928D	DO229240	THCA	ICGC	PATSS	DEG_SPOP_SBC_1	0.2778
p.P936S	DO41361	UCEC	ICGC	PATSS	DEG_SPOP_SBC_1	0.2778
p.P936S	ACH-000997	Colon/Colorectal Cancer	CCLE	PATSS	DEG_SPOP_SBC_1	0.2778
p.S939F	SIDM00587	Biliary Tract Carcinoma	GDSC	PATSS	DEG_SPOP_SBC_1	0.1944
p.S939F	ACH-000976	Bile Duct Cancer	CCLE	PATSS	DEG_SPOP_SBC_1	0.1944
p.S939F	HuCCT1	biliary_tract	COSMIC	PATSS	DEG_SPOP_SBC_1	0.1944
p.T929P	SIDM00257	Neuroblastoma	GDSC	PATSS	DEG_SPOP_SBC_1	0.3056
p.T929P	ACH-002280	Neuroblastoma	CCLE	PATSS	DEG_SPOP_SBC_1	0.3056
p.T924N	ACH-000941	Endometrial/Uterine Cancer	CCLE	PATSS	DEG_SPOP_SBC_1	0.1667
p.T924N	ACH-000954	Endometrial/Uterine Cancer	CCLE	PATSS	DEG_SPOP_SBC_1	0.1667
p.T943M	MOLT-4	haematopoietic_and_lymphoid_tissue	COSMIC	PATSS	DEG_SPOP_SBC_1	0.0833
p.S941G	T-T	oesophagus	COSMIC	PATSS	DEG_SPOP_SBC_1	0.1389
p.T939M	WSU-NHL	haematopoietic_and_lymphoid_tissue	COSMIC	PATSS	DEG_SPOP_SBC_1	0.1944
p.A929T	C-33-A	cervix	COSMIC	PATSS	DEG_SPOP_SBC_1	0.3056

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
A6NGG8	Photoreceptor cilium actin regulator	DEG_SPOP_SBC_1	1125:1129	PATSS	SPOP	0.9621	More...
A8CG34	Nuclear envelope pore membrane protein POM 121C	DEG_SPOP_SBC_1	907:911	PATSS	SPOP	0.9948	More...
O60504	Vinexin	DEG_SPOP_SBC_1	189:193	PATSS	SPOP	0.9439	More...
O75081	Protein CBFA2T3	DEG_SPOP_SBC_1	152:156	PATSS	SPOP	0.7702	More...
P28908	Tumor necrosis factor receptor superfamily member 8	DEG_SPOP_SBC_1	184:188	PATSS	SPOP	0.9966	More...
P31270	Homeobox protein Hox-A11	DEG_SPOP_SBC_1	187:191	PATSS	SPOP	0.8903	More...
P35227	Polycomb group RING finger protein 2	DEG_SPOP_SBC_1	270:274	PATSS	SPOP	0.9677	More...
P40200	T-cell surface protein tactile	DEG_SPOP_SBC_1	412:416	PATSS	SPOP	0.9237	More...
P52948	Nuclear pore complex protein Nup98-Nup96	DEG_SPOP_SBC_1	232:236	PATSS	SPOP	0.8979	More...
P54252	Ataxin-3	DEG_SPOP_SBC_1	319:323	PATSS	SPOP	0.9966	More...
Q03112	Histone-lysine N-methyltransferase MECOM	DEG_SPOP_SBC_1	49:53	PATSS	SPOP	0.9868	More...
Q14687	Genetic suppressor element 1	DEG_SPOP_SBC_1	44:48	PATSS	SPOP	0.9439	More...
Q5SSJ5	Heterochromatin protein 1-binding protein 3	DEG_SPOP_SBC_1	87:91	PATSS	SPOP	0.9842	More...
Q63HK5	Teashirt homolog 3	DEG_SPOP_SBC_1	815:819	PATSS	SPOP	0.9964	More...
Q6P4R8	Nuclear factor related to kappa-B-binding protein	DEG_SPOP_SBC_1	892:896	PATSS	SPOP	0.9948	More...
Q8IXZ2	Zinc finger CCCH domain-containing protein 3	DEG_SPOP_SBC_1	364:368	PATSS	SPOP	0.9027	More...
Q8WXI7	Mucin-16	DEG_SPOP_SBC_1	1004:1008	PATSS	SPOP	0.9683	More...
Q92502	StAR-related lipid transfer protein 8	DEG_SPOP_SBC_1	61:65	PATSS	SPOP	0.8873	More...
Q92581	Sodium/hydrogen exchanger 6	DEG_SPOP_SBC_1	611:615	PATSS	SPOP	0.9967	More...
Q96CB8	Integrator complex subunit 12	DEG_SPOP_SBC_1	321:325	PATSS	SPOP	0.8945	More...
Q96HA1	Nuclear envelope pore membrane protein POM 121	DEG_SPOP_SBC_1	930:934	PATSS	SPOP	0.9895	More...
Q9H4A3	Serine/threonine-protein kinase WNK1	DEG_SPOP_SBC_1	1357:1361	PATSS	SPOP	0.96	More...
Q9H7N4	Splicing factor, arginine/serine-rich 19	DEG_SPOP_SBC_1	617:621	PATSS	SPOP	0.9725	More...
Q9HBZ2	Aryl hydrocarbon receptor nuclear translocator 2	DEG_SPOP_SBC_1	619:623	PATSS	SPOP	0.9524	More...
Q9HC84	Mucin-5B	DEG_SPOP_SBC_1	1889:1893	PATSS	SPOP	0.9045	More...
Q9HC84	Mucin-5B	DEG_SPOP_SBC_1	4232:4236	PATSS	SPOP	0.6101	More...
Q9HCE9	Anoctamin-8	DEG_SPOP_SBC_1	939:943	PATSS	SPOP	0.7199	More...
Q9NRR5	Ubiquilin-4	DEG_SPOP_SBC_1	521:525	PATSS	SPOP	0.994	More...
Q9UKP3	Integrin beta-1-binding protein 2	DEG_SPOP_SBC_1	78:82	PATSS	SPOP	0.9254	More...
Q9UMN6	Histone-lysine N-methyltransferase 2B	DEG_SPOP_SBC_1	637:641	PATSS	SPOP	0.7297	More...
Q9UPP1	Histone lysine demethylase PHF8	DEG_SPOP_SBC_1	774:778	PATSS	SPOP	0.9112	More...
A6NF01	Putative nuclear envelope pore membrane protein POM 121B	DEG_SPOP_SBC_1	514:518	PATSS	SPOP	0.985	More...
A6NNC1	Putative POM121-like protein 1-like	DEG_SPOP_SBC_1	563:567	PATSS	SPOP	0.9988	More...
A6NNC1	Putative POM121-like protein 1-like	DEG_SPOP_SBC_1	835:839	PATSS	SPOP	0.9635	More...
Q3SYA9	Putative POM121-like protein 1	DEG_SPOP_SBC_1	333:337	PATSS	SPOP	0.9106	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: PATSS

Degron related mutations and impact score

Drug responses associated with POM121 mutations

All proteins holding degron of PATSS