DegronMD - Q63HK5(TSHZ3)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.P815T	TCGA-05-4430	LUAD	TCGA	PATSS	DEG_SPOP_SBC_1	815:819	Mutation altering degron motif	0.7031
p.P815T	DO23750	LUAD	ICGC	PATSS	DEG_SPOP_SBC_1	815:819	Mutation altering degron motif	0.7031
p.L807I	TCGA-17-Z049	LUAD	TCGA	PATSS	DEG_SPOP_SBC_1	815:819	Mutation rewiring degron network	0.1111
p.L438P	TCGA-24-1469	OV	TCGA	PVTPTIT	DEG_SCF_FBW7_1	429:435	Mutation rewiring degron network	0.25
p.L438P	DO32626	OV	ICGC	PVTPTIT	DEG_SCF_FBW7_1	429:435	Mutation rewiring degron network	0.25
p.K421N	TCGA-50-5941	LUAD	TCGA	PVTPTIT	DEG_SCF_FBW7_1	429:435	Mutation substituting flanking lysine	0.2222
p.K421N	DO25528	LUAD	ICGC	PVTPTIT	DEG_SCF_FBW7_1	429:435	Mutation substituting flanking lysine	0.2222
p.T428P	TCGA-62-A46S	LUAD	TCGA	PVTPTIT	DEG_SCF_FBW7_1	429:435	Mutation blocking phosphorylation signal	0.75
p.T428P	DO45330	LUAD	ICGC	PVTPTIT	DEG_SCF_FBW7_1	429:435	Mutation blocking phosphorylation signal	0.75
p.T428M	TCGA-69-8255	LUAD	TCGA	PVTPTIT	DEG_SCF_FBW7_1	429:435	Mutation blocking phosphorylation signal	0.75
p.T428M	DO25360	LUAD	ICGC	PVTPTIT	DEG_SCF_FBW7_1	429:435	Mutation blocking phosphorylation signal	0.75
p.S819L	TCGA-78-7162	LUAD	TCGA	PATSS	DEG_SPOP_SBC_1	815:819	Mutation altering degron motif	0.7667
p.S819L	DO25917	LUAD	ICGC	PATSS	DEG_SPOP_SBC_1	815:819	Mutation altering degron motif	0.7667
p.P815L	TCGA-A6-5656	COAD	TCGA	PATSS	DEG_SPOP_SBC_1	815:819	Mutation altering degron motif	0.7582
p.P815L	DO8498	COAD	ICGC	PATSS	DEG_SPOP_SBC_1	815:819	Mutation altering degron motif	0.7582
p.P432H	TCGA-AA-3492	COAD	TCGA	PVTPTIT	DEG_SCF_FBW7_1	429:435	Mutation altering degron motif	0.7694
p.P432H	DO8224	COAD	ICGC	PVTPTIT	DEG_SCF_FBW7_1	429:435	Mutation altering degron motif	0.7694
p.P429H	TCGA-B5-A0K6	UCEC	TCGA	PVTPTIT	DEG_SCF_FBW7_1	429:435	Mutation altering degron motif	0.7694
p.P429H	DO40808	UCEC	ICGC	PVTPTIT	DEG_SCF_FBW7_1	429:435	Mutation altering degron motif	0.7694
p.T824M	TCGA-B7-5816	STAD	TCGA	PATSS	DEG_SPOP_SBC_1	815:819	Mutation blocking phosphorylation signal	0.6389
p.T824M	TCGA-G4-6302	COAD	TCGA	PATSS	DEG_SPOP_SBC_1	815:819	Mutation blocking phosphorylation signal	0.6389
p.T824M	DO8778	COAD	ICGC	PATSS	DEG_SPOP_SBC_1	815:819	Mutation blocking phosphorylation signal	0.6389
p.T824M	DO234209	ESAD	ICGC	PATSS	DEG_SPOP_SBC_1	815:819	Mutation blocking phosphorylation signal	0.6389
p.T824M	DO38599	STAD	ICGC	PATSS	DEG_SPOP_SBC_1	815:819	Mutation blocking phosphorylation signal	0.6389
p.T824M	SIDM00046	Non-Small Cell Lung Carcinoma	GDSC	PATSS	DEG_SPOP_SBC_1	815:819	Mutation blocking phosphorylation signal	0.6389
p.T824M	SIDM00163	Biliary Tract Carcinoma	GDSC	PATSS	DEG_SPOP_SBC_1	815:819	Mutation blocking phosphorylation signal	0.6389
p.T824M	ACH-000109	Lung Cancer	CCLE	PATSS	DEG_SPOP_SBC_1	815:819	Mutation blocking phosphorylation signal	0.6389
p.T824M	ACH-000461	Bile Duct Cancer	CCLE	PATSS	DEG_SPOP_SBC_1	815:819	Mutation blocking phosphorylation signal	0.6389
p.T824M	H3255	lung	COSMIC	PATSS	DEG_SPOP_SBC_1	815:819	Mutation blocking phosphorylation signal	0.6389
p.K420I	TCGA-CV-A45W	HNSC	TCGA	PVTPTIT	DEG_SCF_FBW7_1	429:435	Mutation substituting flanking lysine	0.1944
p.K420I	DO52060	HNSC	ICGC	PVTPTIT	DEG_SCF_FBW7_1	429:435	Mutation substituting flanking lysine	0.1944
p.T811M	TCGA-D8-A1JA	BRCA	TCGA	PATSS	DEG_SPOP_SBC_1	815:819	Mutation rewiring degron network	0.2222
p.T811M	DO2819	BRCA	ICGC	PATSS	DEG_SPOP_SBC_1	815:819	Mutation rewiring degron network	0.2222
p.S805L	TCGA-DM-A28H	COAD	TCGA	PATSS	DEG_SPOP_SBC_1	815:819	Mutation rewiring degron network	0.0556
p.S805L	DO8906	COAD	ICGC	PATSS	DEG_SPOP_SBC_1	815:819	Mutation rewiring degron network	0.0556
p.V426L	TCGA-NK-A5CR	LUSC	TCGA	PVTPTIT	DEG_SCF_FBW7_1	429:435	Mutation rewiring degron network	0.25
p.V426L	DO219207	LUSC	ICGC	PVTPTIT	DEG_SCF_FBW7_1	429:435	Mutation rewiring degron network	0.25
p.T821M	TCGA-T9-A92H	COAD	TCGA	PATSS	DEG_SPOP_SBC_1	815:819	Mutation rewiring degron network	0.2778
p.T821M	DO223706	COAD	ICGC	PATSS	DEG_SPOP_SBC_1	815:819	Mutation rewiring degron network	0.2778
p.T823K	DO229037	LICA	ICGC	PATSS	DEG_SPOP_SBC_1	815:819	Mutation rewiring degron network	0.2222
p.T813A	DO231191	LUSC	ICGC	PATSS	DEG_SPOP_SBC_1	815:819	Mutation rewiring degron network	0.2778
p.PA815PT	DO222837	MELA	ICGC	PATSS	DEG_SPOP_SBC_1	815:819	Mutation altering degron motif	0.7031
p.S819P	DO49193	PACA	ICGC	PATSS	DEG_SPOP_SBC_1	815:819	Mutation altering degron motif	0.6752
p.V445M	SIDM00541	Colorectal Carcinoma	GDSC	PVTPTIT	DEG_SCF_FBW7_1	429:435	Mutation rewiring degron network	0.0556
p.V445M	SIDM00270	Head and Neck Carcinoma	GDSC	PVTPTIT	DEG_SCF_FBW7_1	429:435	Mutation rewiring degron network	0.0556
p.V445M	SIDM00255	Neuroblastoma	GDSC	PVTPTIT	DEG_SCF_FBW7_1	429:435	Mutation rewiring degron network	0.0556
p.V445M	SIDM00965	Small Cell Lung Carcinoma	GDSC	PVTPTIT	DEG_SCF_FBW7_1	429:435	Mutation rewiring degron network	0.0556
p.V445M	SIDM00801	Melanoma	GDSC	PVTPTIT	DEG_SCF_FBW7_1	429:435	Mutation rewiring degron network	0.0556
p.V445M	SIDM01518	Oral Cavity Carcinoma	GDSC	PVTPTIT	DEG_SCF_FBW7_1	429:435	Mutation rewiring degron network	0.0556
p.A814P	SIDM00189	Melanoma	GDSC	PATSS	DEG_SPOP_SBC_1	815:819	Mutation rewiring degron network	0.3056
p.A814P	ACH-002098	Skin Cancer	CCLE	PATSS	DEG_SPOP_SBC_1	815:819	Mutation rewiring degron network	0.3056
p.A814P	CP67-MEL	skin	COSMIC	PATSS	DEG_SPOP_SBC_1	815:819	Mutation rewiring degron network	0.3056
p.A814S	SIDM00845	Burkitt's Lymphoma	GDSC	PATSS	DEG_SPOP_SBC_1	815:819	Mutation rewiring degron network	0.3056
p.A814S	SIDM00461	Acute Myeloid Leukemia	GDSC	PATSS	DEG_SPOP_SBC_1	815:819	Mutation rewiring degron network	0.3056
p.A814S	Daudi	haematopoietic and lymphoid tissue	COSMIC	PATSS	DEG_SPOP_SBC_1	815:819	Mutation rewiring degron network	0.3056
p.A814S	OCI-AML5	haematopoietic and lymphoid tissue	COSMIC	PATSS	DEG_SPOP_SBC_1	815:819	Mutation rewiring degron network	0.3056
p.Q443P	SIDM00329	Hodgkin's Lymphoma	GDSC	PVTPTIT	DEG_SCF_FBW7_1	429:435	Mutation rewiring degron network	0.1111
p.Q443P	ACH-000806	Lymphoma	CCLE	PVTPTIT	DEG_SCF_FBW7_1	429:435	Mutation rewiring degron network	0.1111
p.Q443P	L-540	haematopoietic and lymphoid tissue	COSMIC	PVTPTIT	DEG_SCF_FBW7_1	429:435	Mutation rewiring degron network	0.1111
p.D439Y	SIDM01611	Endometrial Carcinoma	GDSC	PVTPTIT	DEG_SCF_FBW7_1	429:435	Mutation rewiring degron network	0.2222
p.D439Y	ACH-000996	Endometrial/Uterine Cancer	CCLE	PVTPTIT	DEG_SCF_FBW7_1	429:435	Mutation rewiring degron network	0.2222
p.K423N	SIDM01611	Endometrial Carcinoma	GDSC	PVTPTIT	DEG_SCF_FBW7_1	429:435	Mutation substituting flanking lysine	0.2778

Kaplan plot for TSHZ3 in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

TSHZ3

UniProt ID: Q63HK5

Entrez ID: 57616

Protein name: Teashirt homolog 3 (Zinc finger protein 537)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for TSHZ3 in