DegronMD

Uniprot ID: Q63HK5

Source protein: Teashirt homolog 3

Source gene: TSHZ3

Class: DEG_SCF_FBW7_1

Location: 429:435

E3 ligase: FBXW7

DEGRON score: 0.9522

ASA_SCORE: 89.3571

COIL: 0.9223

CONS_SCORE: 0.4016

DSS_SCORE: 0.3828

HELIX: 0.0219

FCONS_SCORE: 0.9122

RIG_SCORE: 0.8253

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.L438P	TCGA-24-1469	OV	TCGA	PVTPTIT	DEG_SCF_FBW7_1	0.25
p.L438P	DO32626	OV	ICGC	PVTPTIT	DEG_SCF_FBW7_1	0.25
p.K421N	TCGA-50-5941	LUAD	TCGA	PVTPTIT	DEG_SCF_FBW7_1	0.2222
p.K421N	DO25528	LUAD	ICGC	PVTPTIT	DEG_SCF_FBW7_1	0.2222
p.T428P	TCGA-62-A46S	LUAD	TCGA	PVTPTIT	DEG_SCF_FBW7_1	0.75
p.T428P	DO45330	LUAD	ICGC	PVTPTIT	DEG_SCF_FBW7_1	0.75
p.T428M	TCGA-69-8255	LUAD	TCGA	PVTPTIT	DEG_SCF_FBW7_1	0.75
p.T428M	DO25360	LUAD	ICGC	PVTPTIT	DEG_SCF_FBW7_1	0.75
p.P432H	TCGA-AA-3492	COAD	TCGA	PVTPTIT	DEG_SCF_FBW7_1	0.7694
p.P432H	DO8224	COAD	ICGC	PVTPTIT	DEG_SCF_FBW7_1	0.7694
p.P429H	TCGA-B5-A0K6	UCEC	TCGA	PVTPTIT	DEG_SCF_FBW7_1	0.7694
p.P429H	DO40808	UCEC	ICGC	PVTPTIT	DEG_SCF_FBW7_1	0.7694
p.K420I	TCGA-CV-A45W	HNSC	TCGA	PVTPTIT	DEG_SCF_FBW7_1	0.1944
p.K420I	DO52060	HNSC	ICGC	PVTPTIT	DEG_SCF_FBW7_1	0.1944
p.V426L	TCGA-NK-A5CR	LUSC	TCGA	PVTPTIT	DEG_SCF_FBW7_1	0.25
p.V426L	DO219207	LUSC	ICGC	PVTPTIT	DEG_SCF_FBW7_1	0.25
p.V445M	SIDM00541	Colorectal Carcinoma	GDSC	PVTPTIT	DEG_SCF_FBW7_1	0.0556
p.V445M	SIDM00270	Head and Neck Carcinoma	GDSC	PVTPTIT	DEG_SCF_FBW7_1	0.0556
p.V445M	SIDM00255	Neuroblastoma	GDSC	PVTPTIT	DEG_SCF_FBW7_1	0.0556
p.V445M	SIDM00965	Small Cell Lung Carcinoma	GDSC	PVTPTIT	DEG_SCF_FBW7_1	0.0556
p.V445M	SIDM00801	Melanoma	GDSC	PVTPTIT	DEG_SCF_FBW7_1	0.0556
p.V445M	SIDM01518	Oral Cavity Carcinoma	GDSC	PVTPTIT	DEG_SCF_FBW7_1	0.0556
p.Q443P	SIDM00329	Hodgkin's Lymphoma	GDSC	PVTPTIT	DEG_SCF_FBW7_1	0.1111
p.Q443P	ACH-000806	Lymphoma	CCLE	PVTPTIT	DEG_SCF_FBW7_1	0.1111
p.Q443P	L-540	haematopoietic_and_lymphoid_tissue	COSMIC	PVTPTIT	DEG_SCF_FBW7_1	0.1111
p.D439Y	SIDM01611	Endometrial Carcinoma	GDSC	PVTPTIT	DEG_SCF_FBW7_1	0.2222
p.D439Y	ACH-000996	Endometrial/Uterine Cancer	CCLE	PVTPTIT	DEG_SCF_FBW7_1	0.2222
p.K423N	SIDM01611	Endometrial Carcinoma	GDSC	PVTPTIT	DEG_SCF_FBW7_1	0.2778

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: PVTPTIT

Degron related mutations and impact score

Drug responses associated with TSHZ3 mutations

All proteins holding degron of PVTPTIT

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q63HK5	Teashirt homolog 3	DEG_SCF_FBW7_1	429:435	PVTPTIT	FBXW7	0.9522	More...