DegronMD: protein-targeted degradation, mutation and drug response to degrons
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BSML
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CGC
Degron:
PATSS
Uniprot ID:
A6NNC1
Source protein:
Putative POM121-like protein 1-like
Source gene:
-
Class:
DEG_SPOP_SBC_1
Location:
563:567
E3 ligase:
SPOP
DEGRON score:
0.9988
ASA_SCORE:
76.64
COIL:
0.9394
CONS_SCORE:
0.1789
DSS_SCORE:
0.6331
HELIX:
0.036
FCONS_SCORE:
1
RIG_SCORE:
0.5726
Degron related mutations and impact score
Mutation
Sample
Cancer
Dataset
Degron
Degron class
Impact score
Drug responses associated with - mutations
Sample
Cancer
Mutation (In Degron?)
Dataset
Drug
IC50
All proteins holding degron of PATSS
Uniprot ID
Source protein
Degron class
Location
Hit
E3 ligase
Degron score
Detail
A6NGG8
Photoreceptor cilium actin regulator
DEG_SPOP_SBC_1
1125:1129
PATSS
SPOP
0.9621
More...
A8CG34
Nuclear envelope pore membrane protein POM 121C
DEG_SPOP_SBC_1
907:911
PATSS
SPOP
0.9948
More...
O60504
Vinexin
DEG_SPOP_SBC_1
189:193
PATSS
SPOP
0.9439
More...
O75081
Protein CBFA2T3
DEG_SPOP_SBC_1
152:156
PATSS
SPOP
0.7702
More...
P28908
Tumor necrosis factor receptor superfamily member 8
DEG_SPOP_SBC_1
184:188
PATSS
SPOP
0.9966
More...
P31270
Homeobox protein Hox-A11
DEG_SPOP_SBC_1
187:191
PATSS
SPOP
0.8903
More...
P35227
Polycomb group RING finger protein 2
DEG_SPOP_SBC_1
270:274
PATSS
SPOP
0.9677
More...
P40200
T-cell surface protein tactile
DEG_SPOP_SBC_1
412:416
PATSS
SPOP
0.9237
More...
P52948
Nuclear pore complex protein Nup98-Nup96
DEG_SPOP_SBC_1
232:236
PATSS
SPOP
0.8979
More...
P54252
Ataxin-3
DEG_SPOP_SBC_1
319:323
PATSS
SPOP
0.9966
More...
Q03112
Histone-lysine N-methyltransferase MECOM
DEG_SPOP_SBC_1
49:53
PATSS
SPOP
0.9868
More...
Q14687
Genetic suppressor element 1
DEG_SPOP_SBC_1
44:48
PATSS
SPOP
0.9439
More...
Q5SSJ5
Heterochromatin protein 1-binding protein 3
DEG_SPOP_SBC_1
87:91
PATSS
SPOP
0.9842
More...
Q63HK5
Teashirt homolog 3
DEG_SPOP_SBC_1
815:819
PATSS
SPOP
0.9964
More...
Q6P4R8
Nuclear factor related to kappa-B-binding protein
DEG_SPOP_SBC_1
892:896
PATSS
SPOP
0.9948
More...
Q8IXZ2
Zinc finger CCCH domain-containing protein 3
DEG_SPOP_SBC_1
364:368
PATSS
SPOP
0.9027
More...
Q8WXI7
Mucin-16
DEG_SPOP_SBC_1
1004:1008
PATSS
SPOP
0.9683
More...
Q92502
StAR-related lipid transfer protein 8
DEG_SPOP_SBC_1
61:65
PATSS
SPOP
0.8873
More...
Q92581
Sodium/hydrogen exchanger 6
DEG_SPOP_SBC_1
611:615
PATSS
SPOP
0.9967
More...
Q96CB8
Integrator complex subunit 12
DEG_SPOP_SBC_1
321:325
PATSS
SPOP
0.8945
More...
Q96HA1
Nuclear envelope pore membrane protein POM 121
DEG_SPOP_SBC_1
930:934
PATSS
SPOP
0.9895
More...
Q9H4A3
Serine/threonine-protein kinase WNK1
DEG_SPOP_SBC_1
1357:1361
PATSS
SPOP
0.96
More...
Q9H7N4
Splicing factor, arginine/serine-rich 19
DEG_SPOP_SBC_1
617:621
PATSS
SPOP
0.9725
More...
Q9HBZ2
Aryl hydrocarbon receptor nuclear translocator 2
DEG_SPOP_SBC_1
619:623
PATSS
SPOP
0.9524
More...
Q9HC84
Mucin-5B
DEG_SPOP_SBC_1
1889:1893
PATSS
SPOP
0.9045
More...
Q9HC84
Mucin-5B
DEG_SPOP_SBC_1
4232:4236
PATSS
SPOP
0.6101
More...
Q9HCE9
Anoctamin-8
DEG_SPOP_SBC_1
939:943
PATSS
SPOP
0.7199
More...
Q9NRR5
Ubiquilin-4
DEG_SPOP_SBC_1
521:525
PATSS
SPOP
0.994
More...
Q9UKP3
Integrin beta-1-binding protein 2
DEG_SPOP_SBC_1
78:82
PATSS
SPOP
0.9254
More...
Q9UMN6
Histone-lysine N-methyltransferase 2B
DEG_SPOP_SBC_1
637:641
PATSS
SPOP
0.7297
More...
Q9UPP1
Histone lysine demethylase PHF8
DEG_SPOP_SBC_1
774:778
PATSS
SPOP
0.9112
More...
A6NF01
Putative nuclear envelope pore membrane protein POM 121B
DEG_SPOP_SBC_1
514:518
PATSS
SPOP
0.985
More...
A6NNC1
Putative POM121-like protein 1-like
DEG_SPOP_SBC_1
563:567
PATSS
SPOP
0.9988
More...
A6NNC1
Putative POM121-like protein 1-like
DEG_SPOP_SBC_1
835:839
PATSS
SPOP
0.9635
More...
Q3SYA9
Putative POM121-like protein 1
DEG_SPOP_SBC_1
333:337
PATSS
SPOP
0.9106
More...