DegronMD

Uniprot ID: Q8WXI7

Source protein: Mucin-16

Source gene: MUC16

Class: DEG_SPOP_SBC_1

Location: 1004:1008

E3 ligase: SPOP

DEGRON score: 0.9683

ASA_SCORE: 84.82

COIL: 0.8856

CONS_SCORE: 0

DSS_SCORE: 0.4494

HELIX: 0.0324

FCONS_SCORE: 0

RIG_SCORE: 0.6913

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.A1011T	TCGA-AA-A010	COAD	TCGA	PATSS	DEG_SPOP_SBC_1	0.25
p.A1011T	ACH-000791	Lung Cancer	CCLE	PATSS	DEG_SPOP_SBC_1	0.25
p.E1016D	TCGA-AJ-A3EL	UCEC	TCGA	PATSS	DEG_SPOP_SBC_1	0.1111
p.E1016D	DO41542	UCEC	ICGC	PATSS	DEG_SPOP_SBC_1	0.1111
p.M1009I	TCGA-DX-A48N	SARC	TCGA	PATSS	DEG_SPOP_SBC_1	0.3056
p.M1009I	DO219986	SARC	ICGC	PATSS	DEG_SPOP_SBC_1	0.3056
p.K1000N	TCGA-EB-A3XB	SKCM	TCGA	PATSS	DEG_SPOP_SBC_1	0.3333
p.K1000N	DO37856	SKCM	ICGC	PATSS	DEG_SPOP_SBC_1	0.3333
p.T1012A	TCGA-EE-A2MI	SKCM	TCGA	PATSS	DEG_SPOP_SBC_1	0.2222
p.T1012A	DO37531	SKCM	ICGC	PATSS	DEG_SPOP_SBC_1	0.2222
p.A994V	TCGA-EE-A3AA	SKCM	TCGA	PATSS	DEG_SPOP_SBC_1	0.0556
p.A994V	TCGA-RP-A694	SKCM	TCGA	PATSS	DEG_SPOP_SBC_1	0.0556
p.A994V	DO222632	MELA	ICGC	PATSS	DEG_SPOP_SBC_1	0.0556
p.A994V	DO37571	SKCM	ICGC	PATSS	DEG_SPOP_SBC_1	0.0556
p.A994V	DO51269	SKCM	ICGC	PATSS	DEG_SPOP_SBC_1	0.0556
p.S1008F	TCGA-XV-AAZY	SKCM	TCGA	PATSS	DEG_SPOP_SBC_1	0.7982
p.S1008F	DO218884	SKCA	ICGC	PATSS	DEG_SPOP_SBC_1	0.7982
p.S1008F	DO219497	SKCM	ICGC	PATSS	DEG_SPOP_SBC_1	0.7982
p.R1015G	DO229010	COCA	ICGC	PATSS	DEG_SPOP_SBC_1	0.1389
p.R1015G	DO229016	COCA	ICGC	PATSS	DEG_SPOP_SBC_1	0.1389
p.R1015G	DO229003	COCA	ICGC	PATSS	DEG_SPOP_SBC_1	0.1389
p.R1015G	DO229005	COCA	ICGC	PATSS	DEG_SPOP_SBC_1	0.1389
p.R1015G	DO234205	ESAD	ICGC	PATSS	DEG_SPOP_SBC_1	0.1389
p.R1015G	DO234285	ESAD	ICGC	PATSS	DEG_SPOP_SBC_1	0.1389
p.R1015G	DO52365	LUSC	ICGC	PATSS	DEG_SPOP_SBC_1	0.1389
p.P1017Q	DO233767	GACA	ICGC	PATSS	DEG_SPOP_SBC_1	0.0833
p.A1005G	DO50944	LICA	ICGC	PATSS	DEG_SPOP_SBC_1	0.6429
p.E1016K	DO232858	NACA	ICGC	PATSS	DEG_SPOP_SBC_1	0.1111
p.E1016K	DO218861	SKCA	ICGC	PATSS	DEG_SPOP_SBC_1	0.1111
p.S1008Y	SIDM00193	Colorectal Carcinoma	GDSC	PATSS	DEG_SPOP_SBC_1	0.712
p.S1008Y	ACH-000991	Colon/Colorectal Cancer	CCLE	PATSS	DEG_SPOP_SBC_1	0.712
p.S1008Y	SNU-81	large_intestine	COSMIC	PATSS	DEG_SPOP_SBC_1	0.712
p.A1011P	ACH-002834	Bone Cancer	CCLE	PATSS	DEG_SPOP_SBC_1	0.25

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
A6NGG8	Photoreceptor cilium actin regulator	DEG_SPOP_SBC_1	1125:1129	PATSS	SPOP	0.9621	More...
A8CG34	Nuclear envelope pore membrane protein POM 121C	DEG_SPOP_SBC_1	907:911	PATSS	SPOP	0.9948	More...
O60504	Vinexin	DEG_SPOP_SBC_1	189:193	PATSS	SPOP	0.9439	More...
O75081	Protein CBFA2T3	DEG_SPOP_SBC_1	152:156	PATSS	SPOP	0.7702	More...
P28908	Tumor necrosis factor receptor superfamily member 8	DEG_SPOP_SBC_1	184:188	PATSS	SPOP	0.9966	More...
P31270	Homeobox protein Hox-A11	DEG_SPOP_SBC_1	187:191	PATSS	SPOP	0.8903	More...
P35227	Polycomb group RING finger protein 2	DEG_SPOP_SBC_1	270:274	PATSS	SPOP	0.9677	More...
P40200	T-cell surface protein tactile	DEG_SPOP_SBC_1	412:416	PATSS	SPOP	0.9237	More...
P52948	Nuclear pore complex protein Nup98-Nup96	DEG_SPOP_SBC_1	232:236	PATSS	SPOP	0.8979	More...
P54252	Ataxin-3	DEG_SPOP_SBC_1	319:323	PATSS	SPOP	0.9966	More...
Q03112	Histone-lysine N-methyltransferase MECOM	DEG_SPOP_SBC_1	49:53	PATSS	SPOP	0.9868	More...
Q14687	Genetic suppressor element 1	DEG_SPOP_SBC_1	44:48	PATSS	SPOP	0.9439	More...
Q5SSJ5	Heterochromatin protein 1-binding protein 3	DEG_SPOP_SBC_1	87:91	PATSS	SPOP	0.9842	More...
Q63HK5	Teashirt homolog 3	DEG_SPOP_SBC_1	815:819	PATSS	SPOP	0.9964	More...
Q6P4R8	Nuclear factor related to kappa-B-binding protein	DEG_SPOP_SBC_1	892:896	PATSS	SPOP	0.9948	More...
Q8IXZ2	Zinc finger CCCH domain-containing protein 3	DEG_SPOP_SBC_1	364:368	PATSS	SPOP	0.9027	More...
Q8WXI7	Mucin-16	DEG_SPOP_SBC_1	1004:1008	PATSS	SPOP	0.9683	More...
Q92502	StAR-related lipid transfer protein 8	DEG_SPOP_SBC_1	61:65	PATSS	SPOP	0.8873	More...
Q92581	Sodium/hydrogen exchanger 6	DEG_SPOP_SBC_1	611:615	PATSS	SPOP	0.9967	More...
Q96CB8	Integrator complex subunit 12	DEG_SPOP_SBC_1	321:325	PATSS	SPOP	0.8945	More...
Q96HA1	Nuclear envelope pore membrane protein POM 121	DEG_SPOP_SBC_1	930:934	PATSS	SPOP	0.9895	More...
Q9H4A3	Serine/threonine-protein kinase WNK1	DEG_SPOP_SBC_1	1357:1361	PATSS	SPOP	0.96	More...
Q9H7N4	Splicing factor, arginine/serine-rich 19	DEG_SPOP_SBC_1	617:621	PATSS	SPOP	0.9725	More...
Q9HBZ2	Aryl hydrocarbon receptor nuclear translocator 2	DEG_SPOP_SBC_1	619:623	PATSS	SPOP	0.9524	More...
Q9HC84	Mucin-5B	DEG_SPOP_SBC_1	1889:1893	PATSS	SPOP	0.9045	More...
Q9HC84	Mucin-5B	DEG_SPOP_SBC_1	4232:4236	PATSS	SPOP	0.6101	More...
Q9HCE9	Anoctamin-8	DEG_SPOP_SBC_1	939:943	PATSS	SPOP	0.7199	More...
Q9NRR5	Ubiquilin-4	DEG_SPOP_SBC_1	521:525	PATSS	SPOP	0.994	More...
Q9UKP3	Integrin beta-1-binding protein 2	DEG_SPOP_SBC_1	78:82	PATSS	SPOP	0.9254	More...
Q9UMN6	Histone-lysine N-methyltransferase 2B	DEG_SPOP_SBC_1	637:641	PATSS	SPOP	0.7297	More...
Q9UPP1	Histone lysine demethylase PHF8	DEG_SPOP_SBC_1	774:778	PATSS	SPOP	0.9112	More...
A6NF01	Putative nuclear envelope pore membrane protein POM 121B	DEG_SPOP_SBC_1	514:518	PATSS	SPOP	0.985	More...
A6NNC1	Putative POM121-like protein 1-like	DEG_SPOP_SBC_1	563:567	PATSS	SPOP	0.9988	More...
A6NNC1	Putative POM121-like protein 1-like	DEG_SPOP_SBC_1	835:839	PATSS	SPOP	0.9635	More...
Q3SYA9	Putative POM121-like protein 1	DEG_SPOP_SBC_1	333:337	PATSS	SPOP	0.9106	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: PATSS

Degron related mutations and impact score

Drug responses associated with MUC16 mutations

All proteins holding degron of PATSS