DegronMD

Uniprot ID: Q03112

Source protein: Histone-lysine N-methyltransferase MECOM

Source gene: MECOM

Class: DEG_SPOP_SBC_1

Location: 49:53

E3 ligase: SPOP

DEGRON score: 0.9868

ASA_SCORE: 56.68

COIL: 0.8322

CONS_SCORE: 0.4726

DSS_SCORE: 0.6408

HELIX: 0.1152

FCONS_SCORE: 1.0244

RIG_SCORE: 0.6305

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.P57L	TCGA-85-7697	LUSC	TCGA	PATSS	DEG_SPOP_SBC_1	0.2222
p.P57L	SIDM00999	Bladder Carcinoma	GDSC	PATSS	DEG_SPOP_SBC_1	0.2222
p.P57L	639-V	urinary_tract	COSMIC	PATSS	DEG_SPOP_SBC_1	0.2222
p.F48L	TCGA-B5-A1MR	UCEC	TCGA	PATSS	DEG_SPOP_SBC_1	0.3056
p.D45N	TCGA-BF-A1Q0	SKCM	TCGA	PATSS	DEG_SPOP_SBC_1	0.2222
p.D45N	TCGA-EE-A29E	SKCM	TCGA	PATSS	DEG_SPOP_SBC_1	0.2222
p.D45N	TCGA-W3-AA1V	SKCM	TCGA	PATSS	DEG_SPOP_SBC_1	0.2222
p.P46S	TCGA-BR-6452	STAD	TCGA	PATSS	DEG_SPOP_SBC_1	0.25
p.A56S	TCGA-CN-6021	HNSC	TCGA	PATSS	DEG_SPOP_SBC_1	0.25
p.E47K	TCGA-IH-A3EA	SKCM	TCGA	PATSS	DEG_SPOP_SBC_1	0.2778
p.E51K	TCGA-OD-A75X	SKCM	TCGA	PATSS	DEG_SPOP_SBC_1	0.7022
p.M53T	TCGA-XU-A92Q	THYM	TCGA	PATSS	DEG_SPOP_SBC_1	0.7423
p.G61S	DO233693	GACA	ICGC	PATSS	DEG_SPOP_SBC_1	0.1111
p.G61S	DO229502	SKCA	ICGC	PATSS	DEG_SPOP_SBC_1	0.1111
p.T57N	DO229019	LICA	ICGC	PATSS	DEG_SPOP_SBC_1	0.2222
p.S48Y	DO49720	LIHC	ICGC	PATSS	DEG_SPOP_SBC_1	0.3056
p.S40P	DO218923	LUAD	ICGC	PATSS	DEG_SPOP_SBC_1	0.0833
p.S62C	DO230961	LUSC	ICGC	PATSS	DEG_SPOP_SBC_1	0.0833
p.S62C	DO224594	LUSC	ICGC	PATSS	DEG_SPOP_SBC_1	0.0833
p.S62C	SIDM00117	Non-Small Cell Lung Carcinoma	GDSC	PATSS	DEG_SPOP_SBC_1	0.0833
p.S62C	ACH-000837	Lung Cancer	CCLE	PATSS	DEG_SPOP_SBC_1	0.0833
p.S62C	NCI-H322M	lung	COSMIC	PATSS	DEG_SPOP_SBC_1	0.0833
p.P49S	DO229494	SKCA	ICGC	PATSS	DEG_SPOP_SBC_1	0.6752
p.I43F	SIDM01156	Small Cell Lung Carcinoma	GDSC	PATSS	DEG_SPOP_SBC_1	0.1667
p.I43F	ACH-000890	Lung Cancer	CCLE	PATSS	DEG_SPOP_SBC_1	0.1667
p.I43F	SW1271	lung	COSMIC	PATSS	DEG_SPOP_SBC_1	0.1667
p.L41R	SIDM00007	Other Solid Cancers	GDSC	PATSS	DEG_SPOP_SBC_1	0.1111
p.L41R	ACH-001550	Skin Cancer	CCLE	PATSS	DEG_SPOP_SBC_1	0.1111
p.L41R	MCC13	skin	COSMIC	PATSS	DEG_SPOP_SBC_1	0.1111
p.A55T	SIDM00282	Colorectal Carcinoma	GDSC	PATSS	DEG_SPOP_SBC_1	0.2778
p.A55T	ACH-000998	Colon/Colorectal Cancer	CCLE	PATSS	DEG_SPOP_SBC_1	0.2778
p.A55T	CW-2	large_intestine	COSMIC	PATSS	DEG_SPOP_SBC_1	0.2778
p.P63R	SIDM00929	Chondrosarcoma	GDSC	PATSS	DEG_SPOP_SBC_1	0.0556
p.P63R	CAL-78	bone	COSMIC	PATSS	DEG_SPOP_SBC_1	0.0556
p.Q40R	ACH-000955	Colon/Colorectal Cancer	CCLE	PATSS	DEG_SPOP_SBC_1	0.0833
p.Q40R	SNU-407	large_intestine	COSMIC	PATSS	DEG_SPOP_SBC_1	0.0833
p.L41V	ACH-001509	Head and Neck Cancer	CCLE	PATSS	DEG_SPOP_SBC_1	0.1111
p.A53E	MHH-NB-11	autonomic_ganglia	COSMIC	PATSS	DEG_SPOP_SBC_1	0.7701

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
A6NGG8	Photoreceptor cilium actin regulator	DEG_SPOP_SBC_1	1125:1129	PATSS	SPOP	0.9621	More...
A8CG34	Nuclear envelope pore membrane protein POM 121C	DEG_SPOP_SBC_1	907:911	PATSS	SPOP	0.9948	More...
O60504	Vinexin	DEG_SPOP_SBC_1	189:193	PATSS	SPOP	0.9439	More...
O75081	Protein CBFA2T3	DEG_SPOP_SBC_1	152:156	PATSS	SPOP	0.7702	More...
P28908	Tumor necrosis factor receptor superfamily member 8	DEG_SPOP_SBC_1	184:188	PATSS	SPOP	0.9966	More...
P31270	Homeobox protein Hox-A11	DEG_SPOP_SBC_1	187:191	PATSS	SPOP	0.8903	More...
P35227	Polycomb group RING finger protein 2	DEG_SPOP_SBC_1	270:274	PATSS	SPOP	0.9677	More...
P40200	T-cell surface protein tactile	DEG_SPOP_SBC_1	412:416	PATSS	SPOP	0.9237	More...
P52948	Nuclear pore complex protein Nup98-Nup96	DEG_SPOP_SBC_1	232:236	PATSS	SPOP	0.8979	More...
P54252	Ataxin-3	DEG_SPOP_SBC_1	319:323	PATSS	SPOP	0.9966	More...
Q03112	Histone-lysine N-methyltransferase MECOM	DEG_SPOP_SBC_1	49:53	PATSS	SPOP	0.9868	More...
Q14687	Genetic suppressor element 1	DEG_SPOP_SBC_1	44:48	PATSS	SPOP	0.9439	More...
Q5SSJ5	Heterochromatin protein 1-binding protein 3	DEG_SPOP_SBC_1	87:91	PATSS	SPOP	0.9842	More...
Q63HK5	Teashirt homolog 3	DEG_SPOP_SBC_1	815:819	PATSS	SPOP	0.9964	More...
Q6P4R8	Nuclear factor related to kappa-B-binding protein	DEG_SPOP_SBC_1	892:896	PATSS	SPOP	0.9948	More...
Q8IXZ2	Zinc finger CCCH domain-containing protein 3	DEG_SPOP_SBC_1	364:368	PATSS	SPOP	0.9027	More...
Q8WXI7	Mucin-16	DEG_SPOP_SBC_1	1004:1008	PATSS	SPOP	0.9683	More...
Q92502	StAR-related lipid transfer protein 8	DEG_SPOP_SBC_1	61:65	PATSS	SPOP	0.8873	More...
Q92581	Sodium/hydrogen exchanger 6	DEG_SPOP_SBC_1	611:615	PATSS	SPOP	0.9967	More...
Q96CB8	Integrator complex subunit 12	DEG_SPOP_SBC_1	321:325	PATSS	SPOP	0.8945	More...
Q96HA1	Nuclear envelope pore membrane protein POM 121	DEG_SPOP_SBC_1	930:934	PATSS	SPOP	0.9895	More...
Q9H4A3	Serine/threonine-protein kinase WNK1	DEG_SPOP_SBC_1	1357:1361	PATSS	SPOP	0.96	More...
Q9H7N4	Splicing factor, arginine/serine-rich 19	DEG_SPOP_SBC_1	617:621	PATSS	SPOP	0.9725	More...
Q9HBZ2	Aryl hydrocarbon receptor nuclear translocator 2	DEG_SPOP_SBC_1	619:623	PATSS	SPOP	0.9524	More...
Q9HC84	Mucin-5B	DEG_SPOP_SBC_1	1889:1893	PATSS	SPOP	0.9045	More...
Q9HC84	Mucin-5B	DEG_SPOP_SBC_1	4232:4236	PATSS	SPOP	0.6101	More...
Q9HCE9	Anoctamin-8	DEG_SPOP_SBC_1	939:943	PATSS	SPOP	0.7199	More...
Q9NRR5	Ubiquilin-4	DEG_SPOP_SBC_1	521:525	PATSS	SPOP	0.994	More...
Q9UKP3	Integrin beta-1-binding protein 2	DEG_SPOP_SBC_1	78:82	PATSS	SPOP	0.9254	More...
Q9UMN6	Histone-lysine N-methyltransferase 2B	DEG_SPOP_SBC_1	637:641	PATSS	SPOP	0.7297	More...
Q9UPP1	Histone lysine demethylase PHF8	DEG_SPOP_SBC_1	774:778	PATSS	SPOP	0.9112	More...
A6NF01	Putative nuclear envelope pore membrane protein POM 121B	DEG_SPOP_SBC_1	514:518	PATSS	SPOP	0.985	More...
A6NNC1	Putative POM121-like protein 1-like	DEG_SPOP_SBC_1	563:567	PATSS	SPOP	0.9988	More...
A6NNC1	Putative POM121-like protein 1-like	DEG_SPOP_SBC_1	835:839	PATSS	SPOP	0.9635	More...
Q3SYA9	Putative POM121-like protein 1	DEG_SPOP_SBC_1	333:337	PATSS	SPOP	0.9106	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: PATSS

Degron related mutations and impact score

Drug responses associated with MECOM mutations

All proteins holding degron of PATSS