DegronMD - P31270(HOXA11)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.S110R	TCGA-A7-A5ZX	BRCA	TCGA	PTPAVS	DEG_SCF_FBW7_1	118:123	Mutation rewiring degron network	0.1111
p.S110R	DO50014	BRCA	ICGC	PTPAVS	DEG_SCF_FBW7_1	118:123	Mutation rewiring degron network	0.1111
p.F126L	TCGA-B5-A0JY	UCEC	TCGA	PTPAVS	DEG_SCF_FBW7_1	118:123	Mutation rewiring degron network	0.25
p.F126L	TCGA-KQ-A41P	BLCA	TCGA	PTPAVS	DEG_SCF_FBW7_1	118:123	Mutation rewiring degron network	0.25
p.F126L	DO223590	BLCA	ICGC	PTPAVS	DEG_SCF_FBW7_1	118:123	Mutation rewiring degron network	0.25
p.F126L	DO43041	UCEC	ICGC	PTPAVS	DEG_SCF_FBW7_1	118:123	Mutation rewiring degron network	0.25
p.S111L	TCGA-FD-A6TC	BLCA	TCGA	PTPAVS	DEG_SCF_FBW7_1	118:123	Mutation rewiring degron network	0.1389
p.S111L	DO49755	BLCA	ICGC	PTPAVS	DEG_SCF_FBW7_1	118:123	Mutation rewiring degron network	0.1389
p.G198C	DO222946	BTCA	ICGC	PATSS	DEG_SPOP_SBC_1	187:191	Mutation rewiring degron network	0.1389
p.S191N	DO50401	ESAD	ICGC	PATSS	DEG_SPOP_SBC_1	187:191	Mutation altering degron motif	0.7069
p.R212L	DO223059	ESCA	ICGC	PESSS	DEG_SPOP_SBC_1	216:220	Mutation rewiring degron network	0.2222
p.R212L	DO223059	ESCA	ICGC	PESSS	DEG_SPOP_SBC_1	222:226	Mutation rewiring degron network	0.0556
p.A206E	DO228974	LICA	ICGC	PESSS	DEG_SPOP_SBC_1	216:220	Mutation rewiring degron network	0.0556
p.S220R	DO229015	LICA	ICGC	PESSS	DEG_SPOP_SBC_1	216:220	Mutation altering degron motif	0.7427
p.N113K	DO229025	LICA	ICGC	PTPAVS	DEG_SCF_FBW7_1	118:123	Mutation rewiring degron network	0.1944
p.A207E	DO229035	LICA	ICGC	PESSS	DEG_SPOP_SBC_1	216:220	Mutation rewiring degron network	0.0833
p.S220N	DO50970	LICA	ICGC	PESSS	DEG_SPOP_SBC_1	216:220	Mutation altering degron motif	0.7069
p.V114I	DO231808	LINC	ICGC	PTPAVS	DEG_SCF_FBW7_1	118:123	Mutation rewiring degron network	0.2222
p.KA232KT	DO222824	MELA	ICGC	PESSS	DEG_SPOP_SBC_1	222:226	Mutation substituting flanking lysine	0.1111
p.D231E	DO228481	PRAD	ICGC	PESSS	DEG_SPOP_SBC_1	222:226	Mutation rewiring degron network	0.1944
p.S225F	DO229470	SKCA	ICGC	PESSS	DEG_SPOP_SBC_1	222:226	Mutation altering degron motif	0.7982
p.S225F	SIDM00225	Melanoma	GDSC	PESSS	DEG_SPOP_SBC_1	222:226	Mutation altering degron motif	0.7982
p.T229A	DO229264	THCA	ICGC	PESSS	DEG_SPOP_SBC_1	216:220	Mutation rewiring degron network	0.0833
p.T229A	DO229264	THCA	ICGC	PESSS	DEG_SPOP_SBC_1	222:226	Mutation rewiring degron network	0.25
p.E230G	DO229275	THCA	ICGC	PESSS	DEG_SPOP_SBC_1	216:220	Mutation rewiring degron network	0.0556
p.E230G	DO229275	THCA	ICGC	PESSS	DEG_SPOP_SBC_1	222:226	Mutation rewiring degron network	0.2222
p.R214G	DO229208	THCA	ICGC	PESSS	DEG_SPOP_SBC_1	216:220	Mutation rewiring degron network	0.2778
p.R214G	DO229208	THCA	ICGC	PESSS	DEG_SPOP_SBC_1	222:226	Mutation rewiring degron network	0.1111
p.R201L	SIDM00700	Non-Small Cell Lung Carcinoma	GDSC	PATSS	DEG_SPOP_SBC_1	187:191	Mutation rewiring degron network	0.0556
p.A178V	SIDM01218	Other Solid Cancers	GDSC	PATSS	DEG_SPOP_SBC_1	187:191	Mutation rewiring degron network	0.0833
p.A178V	ACH-001530	Endometrial/Uterine Cancer	CCLE	PATSS	DEG_SPOP_SBC_1	187:191	Mutation rewiring degron network	0.0833
p.E208K	ACH-000783	Breast Cancer	CCLE	PESSS	DEG_SPOP_SBC_1	216:220	Mutation rewiring degron network	0.1111
p.R214W	ACH-000941	Endometrial/Uterine Cancer	CCLE	PESSS	DEG_SPOP_SBC_1	216:220	Mutation rewiring degron network	0.2778
p.R214W	ACH-000941	Endometrial/Uterine Cancer	CCLE	PESSS	DEG_SPOP_SBC_1	222:226	Mutation rewiring degron network	0.1111

Kaplan plot for HOXA11 in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

HOXA11

UniProt ID: P31270

Entrez ID: 3207

Protein name: Homeobox protein Hox-A11 (Homeobox protein Hox-1I)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for HOXA11 in