DegronMD

Uniprot ID: P31270

Source protein: Homeobox protein Hox-A11

Source gene: HOXA11

Class: DEG_SCF_FBW7_1

Location: 118:123

E3 ligase: FBXW7

DEGRON score: 0.8011

ASA_SCORE: 40.6667

COIL: 0.9263

CONS_SCORE: 0.5181

DSS_SCORE: 0.3142

HELIX: 0.0315

FCONS_SCORE: 0.9877

RIG_SCORE: 0.7102

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.S110R	TCGA-A7-A5ZX	BRCA	TCGA	PTPAVS	DEG_SCF_FBW7_1	0.1111
p.S110R	DO50014	BRCA	ICGC	PTPAVS	DEG_SCF_FBW7_1	0.1111
p.F126L	TCGA-B5-A0JY	UCEC	TCGA	PTPAVS	DEG_SCF_FBW7_1	0.25
p.F126L	TCGA-KQ-A41P	BLCA	TCGA	PTPAVS	DEG_SCF_FBW7_1	0.25
p.F126L	DO223590	BLCA	ICGC	PTPAVS	DEG_SCF_FBW7_1	0.25
p.F126L	DO43041	UCEC	ICGC	PTPAVS	DEG_SCF_FBW7_1	0.25
p.S111L	TCGA-FD-A6TC	BLCA	TCGA	PTPAVS	DEG_SCF_FBW7_1	0.1389
p.S111L	DO49755	BLCA	ICGC	PTPAVS	DEG_SCF_FBW7_1	0.1389
p.N113K	DO229025	LICA	ICGC	PTPAVS	DEG_SCF_FBW7_1	0.1944
p.V114I	DO231808	LINC	ICGC	PTPAVS	DEG_SCF_FBW7_1	0.2222

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P31270	Homeobox protein Hox-A11	DEG_SCF_FBW7_1	118:123	PTPAVS	FBXW7	0.8011	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons