DegronMD - Q03112(MECOM)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.E750K	TCGA-63-A5M9	LUSC	TCGA	PLTPVPS	DEG_SCF_FBW7_1	753:759	Mutation rewiring degron network	0.25
p.P57L	TCGA-85-7697	LUSC	TCGA	PATSS	DEG_SPOP_SBC_1	49:53	Mutation rewiring degron network	0.2222
p.P57L	SIDM00999	Bladder Carcinoma	GDSC	PATSS	DEG_SPOP_SBC_1	49:53	Mutation rewiring degron network	0.2222
p.P57L	639-V	urinary tract	COSMIC	PATSS	DEG_SPOP_SBC_1	49:53	Mutation rewiring degron network	0.2222
p.I705V	TCGA-A5-A0G2	UCEC	TCGA	MYPFPD	LIG_APCC_ABBA_1	707:712	Mutation rewiring degron network	0.2778
p.A719D	TCGA-AP-A059	UCEC	TCGA	MYPFPD	LIG_APCC_ABBA_1	707:712	Mutation rewiring degron network	0.1389
p.S594L	TCGA-AX-A1CE	UCEC	TCGA	VSTPSGS	DEG_SCF_FBW7_1	585:591	Mutation rewiring degron network	0.25
p.S594L	TCGA-D3-A3ML	SKCM	TCGA	VSTPSGS	DEG_SCF_FBW7_1	585:591	Mutation rewiring degron network	0.25
p.S594L	TCGA-EE-A2GC	SKCM	TCGA	VSTPSGS	DEG_SCF_FBW7_1	585:591	Mutation rewiring degron network	0.25
p.S594L	TCGA-EE-A2GR	SKCM	TCGA	VSTPSGS	DEG_SCF_FBW7_1	585:591	Mutation rewiring degron network	0.25
p.S594L	TCGA-EO-A22U	UCEC	TCGA	VSTPSGS	DEG_SCF_FBW7_1	585:591	Mutation rewiring degron network	0.25
p.D591G	TCGA-AX-A2HJ	UCEC	TCGA	VSTPSGS	DEG_SCF_FBW7_1	585:591	Mutation altering degron motif	0.7198
p.S594P	TCGA-B5-A11F	UCEC	TCGA	VSTPSGS	DEG_SCF_FBW7_1	585:591	Mutation rewiring degron network	0.25
p.F48L	TCGA-B5-A1MR	UCEC	TCGA	PATSS	DEG_SPOP_SBC_1	49:53	Mutation rewiring degron network	0.3056
p.D45N	TCGA-BF-A1Q0	SKCM	TCGA	PATSS	DEG_SPOP_SBC_1	49:53	Mutation rewiring degron network	0.2222
p.D45N	TCGA-EE-A29E	SKCM	TCGA	PATSS	DEG_SPOP_SBC_1	49:53	Mutation rewiring degron network	0.2222
p.D45N	TCGA-W3-AA1V	SKCM	TCGA	PATSS	DEG_SPOP_SBC_1	49:53	Mutation rewiring degron network	0.2222
p.P46S	TCGA-BR-6452	STAD	TCGA	PATSS	DEG_SPOP_SBC_1	49:53	Mutation rewiring degron network	0.25
p.A56S	TCGA-CN-6021	HNSC	TCGA	PATSS	DEG_SPOP_SBC_1	49:53	Mutation rewiring degron network	0.25
p.D703N	TCGA-D3-A1Q5	SKCM	TCGA	MYPFPD	LIG_APCC_ABBA_1	707:712	Mutation rewiring degron network	0.2222
p.P578S	TCGA-D3-A8GB	SKCM	TCGA	VSTPSGS	DEG_SCF_FBW7_1	585:591	Mutation rewiring degron network	0.1389
p.E722Q	TCGA-DK-A3IS	BLCA	TCGA	MYPFPD	LIG_APCC_ABBA_1	707:712	Mutation rewiring degron network	0.0556
p.P588S	TCGA-EE-A29P	SKCM	TCGA	VSTPSGS	DEG_SCF_FBW7_1	585:591	Mutation altering degron motif	0.6752
p.M599I	TCGA-ER-A19F	SKCM	TCGA	VSTPSGS	DEG_SCF_FBW7_1	585:591	Mutation rewiring degron network	0.1111
p.P699S	TCGA-ER-A42L	SKCM	TCGA	MYPFPD	LIG_APCC_ABBA_1	707:712	Mutation rewiring degron network	0.1111
p.S772L	TCGA-FS-A1ZE	SKCM	TCGA	PPVTPATS	DEG_SCF_FBW7_1	761:768	Mutation rewiring degron network	0.2222
p.M702I	TCGA-FY-A3BL	THCA	TCGA	MYPFPD	LIG_APCC_ABBA_1	707:712	Mutation rewiring degron network	0.1944
p.E47K	TCGA-IH-A3EA	SKCM	TCGA	PATSS	DEG_SPOP_SBC_1	49:53	Mutation rewiring degron network	0.2778
p.E51K	TCGA-OD-A75X	SKCM	TCGA	PATSS	DEG_SPOP_SBC_1	49:53	Mutation altering degron motif	0.7022
p.E768K	TCGA-Q1-A73O	CESC	TCGA	PPVTPATS	DEG_SCF_FBW7_1	761:768	Mutation altering degron motif	0.7022
p.E718Q	TCGA-XF-AAMZ	BLCA	TCGA	MYPFPD	LIG_APCC_ABBA_1	707:712	Mutation rewiring degron network	0.1667
p.M53T	TCGA-XU-A92Q	THYM	TCGA	PATSS	DEG_SPOP_SBC_1	49:53	Mutation altering degron motif	0.7423
p.D600N	DO48428	BLCA	ICGC	VSTPSGS	DEG_SCF_FBW7_1	585:591	Mutation rewiring degron network	0.0833
p.S597L	DO51900	BLCA	ICGC	VSTPSGS	DEG_SCF_FBW7_1	585:591	Mutation rewiring degron network	0.1667
p.S597L	DO219219	LUSC	ICGC	VSTPSGS	DEG_SCF_FBW7_1	585:591	Mutation rewiring degron network	0.1667
p.D743H	DO1088	BRCA	ICGC	PLTPVPS	DEG_SCF_FBW7_1	753:759	Mutation rewiring degron network	0.0556
p.V757I	DO222404	BTCA	ICGC	PLTPVPS	DEG_SCF_FBW7_1	753:759	Mutation altering degron motif	0.5965
p.D583H	DO222937	BTCA	ICGC	VSTPSGS	DEG_SCF_FBW7_1	585:591	Mutation rewiring degron network	0.2778
p.A766T	DO230309	COCA	ICGC	PPVTPATS	DEG_SCF_FBW7_1	761:768	Mutation altering degron motif	0.6028
p.G61S	DO233693	GACA	ICGC	PATSS	DEG_SPOP_SBC_1	49:53	Mutation rewiring degron network	0.1111
p.G61S	DO229502	SKCA	ICGC	PATSS	DEG_SPOP_SBC_1	49:53	Mutation rewiring degron network	0.1111
p.G598D	DO218981	HNSC	ICGC	VSTPSGS	DEG_SCF_FBW7_1	585:591	Mutation rewiring degron network	0.1389
p.T57N	DO229019	LICA	ICGC	PATSS	DEG_SPOP_SBC_1	49:53	Mutation rewiring degron network	0.2222
p.S48Y	DO49720	LIHC	ICGC	PATSS	DEG_SPOP_SBC_1	49:53	Mutation rewiring degron network	0.3056
p.P756A	DO52291	LIHC	ICGC	PLTPVPS	DEG_SCF_FBW7_1	753:759	Mutation altering degron motif	0.7503
p.S40P	DO218923	LUAD	ICGC	PATSS	DEG_SPOP_SBC_1	49:53	Mutation rewiring degron network	0.0833
p.S62C	DO230961	LUSC	ICGC	PATSS	DEG_SPOP_SBC_1	49:53	Mutation rewiring degron network	0.0833
p.S62C	DO224594	LUSC	ICGC	PATSS	DEG_SPOP_SBC_1	49:53	Mutation rewiring degron network	0.0833
p.S62C	SIDM00117	Non-Small Cell Lung Carcinoma	GDSC	PATSS	DEG_SPOP_SBC_1	49:53	Mutation rewiring degron network	0.0833
p.S62C	ACH-000837	Lung Cancer	CCLE	PATSS	DEG_SPOP_SBC_1	49:53	Mutation rewiring degron network	0.0833
p.S62C	NCI-H322M	lung	COSMIC	PATSS	DEG_SPOP_SBC_1	49:53	Mutation rewiring degron network	0.0833
p.D584N	DO45482	LUSC	ICGC	VSTPSGS	DEG_SCF_FBW7_1	585:591	Mutation rewiring degron network	0.3056
p.D584N	DO51274	SKCM	ICGC	VSTPSGS	DEG_SCF_FBW7_1	585:591	Mutation rewiring degron network	0.3056
p.S599F	DO222418	MELA	ICGC	VSTPSGS	DEG_SCF_FBW7_1	585:591	Mutation rewiring degron network	0.1111
p.P711S	DO222516	MELA	ICGC	MYPFPD	LIG_APCC_ABBA_1	707:712	Mutation altering degron motif	0.5641
p.P711S	DO37916	SKCM	ICGC	MYPFPD	LIG_APCC_ABBA_1	707:712	Mutation altering degron motif	0.5641
p.S717L	DO222632	MELA	ICGC	MYPFPD	LIG_APCC_ABBA_1	707:712	Mutation rewiring degron network	0.1944
p.S717L	DO37839	SKCM	ICGC	MYPFPD	LIG_APCC_ABBA_1	707:712	Mutation rewiring degron network	0.1944
p.S717L	DO47413	SKCM	ICGC	MYPFPD	LIG_APCC_ABBA_1	707:712	Mutation rewiring degron network	0.1944
p.S717L	DO37996	SKCM	ICGC	MYPFPD	LIG_APCC_ABBA_1	707:712	Mutation rewiring degron network	0.1944
p.S717L	DO42280	UCEC	ICGC	MYPFPD	LIG_APCC_ABBA_1	707:712	Mutation rewiring degron network	0.1944
p.S717L	DO43755	UCEC	ICGC	MYPFPD	LIG_APCC_ABBA_1	707:712	Mutation rewiring degron network	0.1944
p.P761H	DO232761	PBCA	ICGC	PPVTPATS	DEG_SCF_FBW7_1	761:768	Mutation altering degron motif	0.7694
p.V757A	DO219873	SKCA	ICGC	PLTPVPS	DEG_SCF_FBW7_1	753:759	Mutation altering degron motif	0.5825
p.P49S	DO229494	SKCA	ICGC	PATSS	DEG_SPOP_SBC_1	49:53	Mutation altering degron motif	0.6752
p.D583N	DO37607	SKCM	ICGC	VSTPSGS	DEG_SCF_FBW7_1	585:591	Mutation rewiring degron network	0.2778
p.M722I	DO37679	SKCM	ICGC	MYPFPD	LIG_APCC_ABBA_1	707:712	Mutation rewiring degron network	0.0556
p.L697I	DO37679	SKCM	ICGC	MYPFPD	LIG_APCC_ABBA_1	707:712	Mutation rewiring degron network	0.0556
p.D774N	DO37547	SKCM	ICGC	PPVTPATS	DEG_SCF_FBW7_1	761:768	Mutation rewiring degron network	0.1667
p.D774N	DO37422	SKCM	ICGC	PPVTPATS	DEG_SCF_FBW7_1	761:768	Mutation rewiring degron network	0.1667
p.R748Q	DO37707	SKCM	ICGC	PLTPVPS	DEG_SCF_FBW7_1	753:759	Mutation rewiring degron network	0.1944
p.R748Q	DO50291	SKCM	ICGC	PLTPVPS	DEG_SCF_FBW7_1	753:759	Mutation rewiring degron network	0.1944
p.P758S	DO37406	SKCM	ICGC	PLTPVPS	DEG_SCF_FBW7_1	753:759	Mutation altering degron motif	0.5641
p.L582I	DO37432	SKCM	ICGC	VSTPSGS	DEG_SCF_FBW7_1	585:591	Mutation rewiring degron network	0.25
p.P701S	DO50280	SKCM	ICGC	MYPFPD	LIG_APCC_ABBA_1	707:712	Mutation rewiring degron network	0.1667
p.D714G	DO42105	UCEC	ICGC	MYPFPD	LIG_APCC_ABBA_1	707:712	Mutation rewiring degron network	0.2778
p.S717P	DO43618	UCEC	ICGC	MYPFPD	LIG_APCC_ABBA_1	707:712	Mutation rewiring degron network	0.1944
p.S577A	DO41379	UCEC	ICGC	VSTPSGS	DEG_SCF_FBW7_1	585:591	Mutation rewiring degron network	0.1111
p.R743G	SIDM01959	Colorectal Carcinoma	GDSC	PLTPVPS	DEG_SCF_FBW7_1	753:759	Mutation rewiring degron network	0.0556
p.I43F	SIDM01156	Small Cell Lung Carcinoma	GDSC	PATSS	DEG_SPOP_SBC_1	49:53	Mutation rewiring degron network	0.1667
p.I43F	ACH-000890	Lung Cancer	CCLE	PATSS	DEG_SPOP_SBC_1	49:53	Mutation rewiring degron network	0.1667
p.I43F	SW1271	lung	COSMIC	PATSS	DEG_SPOP_SBC_1	49:53	Mutation rewiring degron network	0.1667
p.V708A	SIDM01021	Glioblastoma	GDSC	MYPFPD	LIG_APCC_ABBA_1	707:712	Mutation altering degron motif	0.6936
p.V708A	D-245MG	central nervous system	COSMIC	MYPFPD	LIG_APCC_ABBA_1	707:712	Mutation altering degron motif	0.6936
p.L41R	SIDM00007	Other Solid Cancers	GDSC	PATSS	DEG_SPOP_SBC_1	49:53	Mutation rewiring degron network	0.1111
p.L41R	ACH-001550	Skin Cancer	CCLE	PATSS	DEG_SPOP_SBC_1	49:53	Mutation rewiring degron network	0.1111
p.L41R	MCC13	skin	COSMIC	PATSS	DEG_SPOP_SBC_1	49:53	Mutation rewiring degron network	0.1111
p.A55T	SIDM00282	Colorectal Carcinoma	GDSC	PATSS	DEG_SPOP_SBC_1	49:53	Mutation rewiring degron network	0.2778
p.A55T	ACH-000998	Colon/Colorectal Cancer	CCLE	PATSS	DEG_SPOP_SBC_1	49:53	Mutation rewiring degron network	0.2778
p.A55T	CW-2	large intestine	COSMIC	PATSS	DEG_SPOP_SBC_1	49:53	Mutation rewiring degron network	0.2778
p.P699L	SIDM00333	Endometrial Carcinoma	GDSC	MYPFPD	LIG_APCC_ABBA_1	707:712	Mutation rewiring degron network	0.1111
p.P699L	MFE-319	endometrium	COSMIC	MYPFPD	LIG_APCC_ABBA_1	707:712	Mutation rewiring degron network	0.1111
p.E718K	SIDM00983	Bladder Carcinoma	GDSC	MYPFPD	LIG_APCC_ABBA_1	707:712	Mutation rewiring degron network	0.1667
p.E718K	647-V	urinary tract	COSMIC	MYPFPD	LIG_APCC_ABBA_1	707:712	Mutation rewiring degron network	0.1667
p.P63R	SIDM00929	Chondrosarcoma	GDSC	PATSS	DEG_SPOP_SBC_1	49:53	Mutation rewiring degron network	0.0556
p.P63R	CAL-78	bone	COSMIC	PATSS	DEG_SPOP_SBC_1	49:53	Mutation rewiring degron network	0.0556
p.M702V	SIDM00349	Esophageal Squamous Cell Carcinoma	GDSC	MYPFPD	LIG_APCC_ABBA_1	707:712	Mutation rewiring degron network	0.1944
p.M702V	TE-10	oesophagus	COSMIC	MYPFPD	LIG_APCC_ABBA_1	707:712	Mutation rewiring degron network	0.1944
p.T598R	ACH-000047	Gastric Cancer	CCLE	VSTPSGS	DEG_SCF_FBW7_1	585:591	Mutation rewiring degron network	0.1389
p.T598R	GCIY	stomach	COSMIC	VSTPSGS	DEG_SCF_FBW7_1	585:591	Mutation rewiring degron network	0.1389
p.R772L	ACH-000576	Myeloma	CCLE	PPVTPATS	DEG_SCF_FBW7_1	761:768	Mutation rewiring degron network	0.2222
p.S593G	ACH-000786	Lymphoma	CCLE	VSTPSGS	DEG_SCF_FBW7_1	585:591	Mutation rewiring degron network	0.2778
p.R718Q	ACH-000856	Breast Cancer	CCLE	MYPFPD	LIG_APCC_ABBA_1	707:712	Mutation rewiring degron network	0.1667
p.R718Q	CAL-51	breast	COSMIC	MYPFPD	LIG_APCC_ABBA_1	707:712	Mutation rewiring degron network	0.1667
p.Q40R	ACH-000955	Colon/Colorectal Cancer	CCLE	PATSS	DEG_SPOP_SBC_1	49:53	Mutation rewiring degron network	0.0833
p.Q40R	SNU-407	large intestine	COSMIC	PATSS	DEG_SPOP_SBC_1	49:53	Mutation rewiring degron network	0.0833
p.R772H	ACH-000999	Colon/Colorectal Cancer	CCLE	PPVTPATS	DEG_SCF_FBW7_1	761:768	Mutation rewiring degron network	0.2222
p.R772H	SNU-1040	large intestine	COSMIC	PPVTPATS	DEG_SCF_FBW7_1	761:768	Mutation rewiring degron network	0.2222
p.L41V	ACH-001509	Head and Neck Cancer	CCLE	PATSS	DEG_SPOP_SBC_1	49:53	Mutation rewiring degron network	0.1111
p.A595T	ACH-002388	Skin Cancer	CCLE	VSTPSGS	DEG_SCF_FBW7_1	585:591	Mutation rewiring degron network	0.2222
p.A53E	MHH-NB-11	autonomic ganglia	COSMIC	PATSS	DEG_SPOP_SBC_1	49:53	Mutation altering degron motif	0.7701
p.T596I	LS-513	large intestine	COSMIC	VSTPSGS	DEG_SCF_FBW7_1	585:591	Mutation rewiring degron network	0.1944
p.D592V	IST-SL2	lung	COSMIC	VSTPSGS	DEG_SCF_FBW7_1	585:591	Mutation rewiring degron network	0.3056
p.T599R	GCIY	stomach	COSMIC	VSTPSGS	DEG_SCF_FBW7_1	585:591	Mutation rewiring degron network	0.1111
p.D575G	ETK-1	biliary tract	COSMIC	VSTPSGS	DEG_SCF_FBW7_1	585:591	Mutation rewiring degron network	0.0556

DegronMD: protein-targeted degradation, mutation and drug response to degrons

MECOM

UniProt ID: Q03112

Entrez ID: 2122

Protein name: Histone-lysine N-methyltransferase MECOM (EC 2.1.1.367) (Ecotropic virus integration site 1 protein homolog) (EVI-1) (MDS1 and EVI1 complex locus protein) (Myelodysplasia syndrome 1 protein) (Myelodysplasia syndrome-associated protein 1)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for MECOM in