DegronMD

Uniprot ID: Q03112

Source protein: Histone-lysine N-methyltransferase MECOM

Source gene: MECOM

Class: DEG_SCF_FBW7_1

Location: 585:591

E3 ligase: FBXW7

DEGRON score: 0.9902

ASA_SCORE: 71.1

COIL: 0.897

CONS_SCORE: 0.5522

DSS_SCORE: 0.7477

HELIX: 0.0433

FCONS_SCORE: 1.3244

RIG_SCORE: 0.5706

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.S594L	TCGA-AX-A1CE	UCEC	TCGA	VSTPSGS	DEG_SCF_FBW7_1	0.25
p.S594L	TCGA-D3-A3ML	SKCM	TCGA	VSTPSGS	DEG_SCF_FBW7_1	0.25
p.S594L	TCGA-EE-A2GC	SKCM	TCGA	VSTPSGS	DEG_SCF_FBW7_1	0.25
p.S594L	TCGA-EE-A2GR	SKCM	TCGA	VSTPSGS	DEG_SCF_FBW7_1	0.25
p.S594L	TCGA-EO-A22U	UCEC	TCGA	VSTPSGS	DEG_SCF_FBW7_1	0.25
p.D591G	TCGA-AX-A2HJ	UCEC	TCGA	VSTPSGS	DEG_SCF_FBW7_1	0.7198
p.S594P	TCGA-B5-A11F	UCEC	TCGA	VSTPSGS	DEG_SCF_FBW7_1	0.25
p.P578S	TCGA-D3-A8GB	SKCM	TCGA	VSTPSGS	DEG_SCF_FBW7_1	0.1389
p.P588S	TCGA-EE-A29P	SKCM	TCGA	VSTPSGS	DEG_SCF_FBW7_1	0.6752
p.M599I	TCGA-ER-A19F	SKCM	TCGA	VSTPSGS	DEG_SCF_FBW7_1	0.1111
p.D600N	DO48428	BLCA	ICGC	VSTPSGS	DEG_SCF_FBW7_1	0.0833
p.S597L	DO51900	BLCA	ICGC	VSTPSGS	DEG_SCF_FBW7_1	0.1667
p.S597L	DO219219	LUSC	ICGC	VSTPSGS	DEG_SCF_FBW7_1	0.1667
p.D583H	DO222937	BTCA	ICGC	VSTPSGS	DEG_SCF_FBW7_1	0.2778
p.G598D	DO218981	HNSC	ICGC	VSTPSGS	DEG_SCF_FBW7_1	0.1389
p.D584N	DO45482	LUSC	ICGC	VSTPSGS	DEG_SCF_FBW7_1	0.3056
p.D584N	DO51274	SKCM	ICGC	VSTPSGS	DEG_SCF_FBW7_1	0.3056
p.S599F	DO222418	MELA	ICGC	VSTPSGS	DEG_SCF_FBW7_1	0.1111
p.D583N	DO37607	SKCM	ICGC	VSTPSGS	DEG_SCF_FBW7_1	0.2778
p.L582I	DO37432	SKCM	ICGC	VSTPSGS	DEG_SCF_FBW7_1	0.25
p.S577A	DO41379	UCEC	ICGC	VSTPSGS	DEG_SCF_FBW7_1	0.1111
p.T598R	ACH-000047	Gastric Cancer	CCLE	VSTPSGS	DEG_SCF_FBW7_1	0.1389
p.T598R	GCIY	stomach	COSMIC	VSTPSGS	DEG_SCF_FBW7_1	0.1389
p.S593G	ACH-000786	Lymphoma	CCLE	VSTPSGS	DEG_SCF_FBW7_1	0.2778
p.A595T	ACH-002388	Skin Cancer	CCLE	VSTPSGS	DEG_SCF_FBW7_1	0.2222
p.T596I	LS-513	large_intestine	COSMIC	VSTPSGS	DEG_SCF_FBW7_1	0.1944
p.D592V	IST-SL2	lung	COSMIC	VSTPSGS	DEG_SCF_FBW7_1	0.3056
p.T599R	GCIY	stomach	COSMIC	VSTPSGS	DEG_SCF_FBW7_1	0.1111
p.D575G	ETK-1	biliary_tract	COSMIC	VSTPSGS	DEG_SCF_FBW7_1	0.0556

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q03112	Histone-lysine N-methyltransferase MECOM	DEG_SCF_FBW7_1	585:591	VSTPSGS	FBXW7	0.9902	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: VSTPSGS

Degron related mutations and impact score

Drug responses associated with MECOM mutations

All proteins holding degron of VSTPSGS