DegronMD

Uniprot ID: Q03112

Source protein: Histone-lysine N-methyltransferase MECOM

Source gene: MECOM

Class: LIG_APCC_ABBA_1

Location: 707:712

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.8204

ASA_SCORE: 84.6

COIL: 0.8762

CONS_SCORE: 0.4072

DSS_SCORE: 0.3259

HELIX: 0.0725

FCONS_SCORE: 1.0493

RIG_SCORE: 0.7366

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.I705V	TCGA-A5-A0G2	UCEC	TCGA	MYPFPD	LIG_APCC_ABBA_1	0.2778
p.A719D	TCGA-AP-A059	UCEC	TCGA	MYPFPD	LIG_APCC_ABBA_1	0.1389
p.D703N	TCGA-D3-A1Q5	SKCM	TCGA	MYPFPD	LIG_APCC_ABBA_1	0.2222
p.E722Q	TCGA-DK-A3IS	BLCA	TCGA	MYPFPD	LIG_APCC_ABBA_1	0.0556
p.P699S	TCGA-ER-A42L	SKCM	TCGA	MYPFPD	LIG_APCC_ABBA_1	0.1111
p.M702I	TCGA-FY-A3BL	THCA	TCGA	MYPFPD	LIG_APCC_ABBA_1	0.1944
p.E718Q	TCGA-XF-AAMZ	BLCA	TCGA	MYPFPD	LIG_APCC_ABBA_1	0.1667
p.P711S	DO222516	MELA	ICGC	MYPFPD	LIG_APCC_ABBA_1	0.5641
p.P711S	DO37916	SKCM	ICGC	MYPFPD	LIG_APCC_ABBA_1	0.5641
p.S717L	DO222632	MELA	ICGC	MYPFPD	LIG_APCC_ABBA_1	0.1944
p.S717L	DO37839	SKCM	ICGC	MYPFPD	LIG_APCC_ABBA_1	0.1944
p.S717L	DO47413	SKCM	ICGC	MYPFPD	LIG_APCC_ABBA_1	0.1944
p.S717L	DO37996	SKCM	ICGC	MYPFPD	LIG_APCC_ABBA_1	0.1944
p.S717L	DO42280	UCEC	ICGC	MYPFPD	LIG_APCC_ABBA_1	0.1944
p.S717L	DO43755	UCEC	ICGC	MYPFPD	LIG_APCC_ABBA_1	0.1944
p.M722I	DO37679	SKCM	ICGC	MYPFPD	LIG_APCC_ABBA_1	0.0556
p.L697I	DO37679	SKCM	ICGC	MYPFPD	LIG_APCC_ABBA_1	0.0556
p.P701S	DO50280	SKCM	ICGC	MYPFPD	LIG_APCC_ABBA_1	0.1667
p.D714G	DO42105	UCEC	ICGC	MYPFPD	LIG_APCC_ABBA_1	0.2778
p.S717P	DO43618	UCEC	ICGC	MYPFPD	LIG_APCC_ABBA_1	0.1944
p.V708A	SIDM01021	Glioblastoma	GDSC	MYPFPD	LIG_APCC_ABBA_1	0.6936
p.V708A	D-245MG	central_nervous_system	COSMIC	MYPFPD	LIG_APCC_ABBA_1	0.6936
p.P699L	SIDM00333	Endometrial Carcinoma	GDSC	MYPFPD	LIG_APCC_ABBA_1	0.1111
p.P699L	MFE-319	endometrium	COSMIC	MYPFPD	LIG_APCC_ABBA_1	0.1111
p.E718K	SIDM00983	Bladder Carcinoma	GDSC	MYPFPD	LIG_APCC_ABBA_1	0.1667
p.E718K	647-V	urinary_tract	COSMIC	MYPFPD	LIG_APCC_ABBA_1	0.1667
p.M702V	SIDM00349	Esophageal Squamous Cell Carcinoma	GDSC	MYPFPD	LIG_APCC_ABBA_1	0.1944
p.M702V	TE-10	oesophagus	COSMIC	MYPFPD	LIG_APCC_ABBA_1	0.1944
p.R718Q	ACH-000856	Breast Cancer	CCLE	MYPFPD	LIG_APCC_ABBA_1	0.1667
p.R718Q	CAL-51	breast	COSMIC	MYPFPD	LIG_APCC_ABBA_1	0.1667

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: MYPFPD

Degron related mutations and impact score

Drug responses associated with MECOM mutations

All proteins holding degron of MYPFPD

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q03112	Histone-lysine N-methyltransferase MECOM	LIG_APCC_ABBA_1	707:712	MYPFPD	APC,CDC20,FZR1	0.8204	More...