DegronMD

Uniprot ID: Q03112

Source protein: Histone-lysine N-methyltransferase MECOM

Source gene: MECOM

Class: DEG_SCF_FBW7_1

Location: 761:768

E3 ligase: FBXW7

DEGRON score: 0.9722

ASA_SCORE: 87.35

COIL: 0.9105

CONS_SCORE: 0.948

DSS_SCORE: 0.766

HELIX: 0.0645

FCONS_SCORE: 0.9616

RIG_SCORE: 0.6168

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.S772L	TCGA-FS-A1ZE	SKCM	TCGA	PPVTPATS	DEG_SCF_FBW7_1	0.2222
p.E768K	TCGA-Q1-A73O	CESC	TCGA	PPVTPATS	DEG_SCF_FBW7_1	0.7022
p.A766T	DO230309	COCA	ICGC	PPVTPATS	DEG_SCF_FBW7_1	0.6028
p.P761H	DO232761	PBCA	ICGC	PPVTPATS	DEG_SCF_FBW7_1	0.7694
p.D774N	DO37547	SKCM	ICGC	PPVTPATS	DEG_SCF_FBW7_1	0.1667
p.D774N	DO37422	SKCM	ICGC	PPVTPATS	DEG_SCF_FBW7_1	0.1667
p.R772L	ACH-000576	Myeloma	CCLE	PPVTPATS	DEG_SCF_FBW7_1	0.2222
p.R772H	ACH-000999	Colon/Colorectal Cancer	CCLE	PPVTPATS	DEG_SCF_FBW7_1	0.2222
p.R772H	SNU-1040	large_intestine	COSMIC	PPVTPATS	DEG_SCF_FBW7_1	0.2222

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q03112	Histone-lysine N-methyltransferase MECOM	DEG_SCF_FBW7_1	761:768	PPVTPATS	FBXW7	0.9722	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons