DegronMD

Uniprot ID: Q03112

Source protein: Histone-lysine N-methyltransferase MECOM

Source gene: MECOM

Class: DEG_SCF_FBW7_1

Location: 753:759

E3 ligase: FBXW7

DEGRON score: 0.9718

ASA_SCORE: 98.4714

COIL: 0.9521

CONS_SCORE: 0.9904

DSS_SCORE: 0.7512

HELIX: 0.0084

FCONS_SCORE: 1.0243

RIG_SCORE: 0.6087

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.E750K	TCGA-63-A5M9	LUSC	TCGA	PLTPVPS	DEG_SCF_FBW7_1	0.25
p.D743H	DO1088	BRCA	ICGC	PLTPVPS	DEG_SCF_FBW7_1	0.0556
p.V757I	DO222404	BTCA	ICGC	PLTPVPS	DEG_SCF_FBW7_1	0.5965
p.P756A	DO52291	LIHC	ICGC	PLTPVPS	DEG_SCF_FBW7_1	0.7503
p.V757A	DO219873	SKCA	ICGC	PLTPVPS	DEG_SCF_FBW7_1	0.5825
p.R748Q	DO37707	SKCM	ICGC	PLTPVPS	DEG_SCF_FBW7_1	0.1944
p.R748Q	DO50291	SKCM	ICGC	PLTPVPS	DEG_SCF_FBW7_1	0.1944
p.P758S	DO37406	SKCM	ICGC	PLTPVPS	DEG_SCF_FBW7_1	0.5641
p.R743G	SIDM01959	Colorectal Carcinoma	GDSC	PLTPVPS	DEG_SCF_FBW7_1	0.0556

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q03112	Histone-lysine N-methyltransferase MECOM	DEG_SCF_FBW7_1	753:759	PLTPVPS	FBXW7	0.9718	More...
Q63HR2	Tensin-2	DEG_SCF_FBW7_1	1031:1037	PLTPVPS	FBXW7	0.9878	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons