DegronMD - Q63HR2(TNS2)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.G1032A	SIDM01314	Colorectal Carcinoma	GDSC	PLTPVPS	DEG_SCF_FBW7_1	1031:1037	Mutation altering degron motif	0.754
p.R540W	SIDM00781	Colorectal Carcinoma	GDSC	ERQELDRLL	DEG_APCC_DBOX_1	537:545	Mutation altering degron motif	0.8634
p.R540W	SIDM00780	Colorectal Carcinoma	GDSC	ERQELDRLL	DEG_APCC_DBOX_1	537:545	Mutation altering degron motif	0.8634
p.R540W	SIDM01451	Pancreatic Carcinoma	GDSC	ERQELDRLL	DEG_APCC_DBOX_1	537:545	Mutation altering degron motif	0.8634
p.V519I	SIDM00860	Head and Neck Carcinoma	GDSC	DSGHSST	DEG_SCF_TRCP1_1	512:518	Mutation rewiring degron network	0.3056
p.V519I	FADU	upper aerodigestive tract	COSMIC	DSGHSST	DEG_SCF_TRCP1_1	512:518	Mutation rewiring degron network	0.3056
p.R1023C	SIDM00296	Small Cell Lung Carcinoma	GDSC	PLTPVPS	DEG_SCF_FBW7_1	1031:1037	Mutation rewiring degron network	0.1111
p.D552N	SIDM00417	Plasma Cell Myeloma	GDSC	ERQELDRLL	DEG_APCC_DBOX_1	537:545	Mutation blocking phosphorylation signal	0.5833
p.D552N	U-266	haematopoietic and lymphoid tissue	COSMIC	ERQELDRLL	DEG_APCC_DBOX_1	537:545	Mutation blocking phosphorylation signal	0.5833
p.G1039W	SIDM00494	Non-Small Cell Lung Carcinoma	GDSC	PLTPVPS	DEG_SCF_FBW7_1	1031:1037	Mutation rewiring degron network	0.2778
p.G1039W	ABC-1	lung	COSMIC	PLTPVPS	DEG_SCF_FBW7_1	1031:1037	Mutation rewiring degron network	0.2778
p.T503S	SIDM01042	Breast Carcinoma	GDSC	DSGHSST	DEG_SCF_TRCP1_1	512:518	Mutation rewiring degron network	0.0833
p.P538A	SIDM01424	B-Lymphoblastic Leukemia	GDSC	ERQELDRLL	DEG_APCC_DBOX_1	537:545	Mutation altering degron motif	0.7503
p.G905W	ABC-1	lung	COSMIC	PSTPLHT	DEG_SCF_FBW7_1	908:914	Mutation rewiring degron network	0.25
p.M915I	SW48	large intestine	COSMIC	PSTPLHT	DEG_SCF_FBW7_1	908:914	Mutation blocking phosphorylation signal	0.75
p.R1174C	SNU-C2B	large intestine	COSMIC	VATPPPS	DEG_SCF_FBW7_1	1180:1186	Mutation rewiring degron network	0.1667
p.G553E	RL95-2	endometrium	COSMIC	ERQELDRLL	DEG_APCC_DBOX_1	537:545	Mutation rewiring degron network	0.1111
p.E1188K	KYSE-520	oesophagus	COSMIC	VATPPPS	DEG_SCF_FBW7_1	1180:1186	Mutation rewiring degron network	0.2778
p.V509I	FADU	upper aerodigestive tract	COSMIC	DSGHSST	DEG_SCF_TRCP1_1	512:518	Mutation rewiring degron network	0.25
p.P1035S	HCT-15	large intestine	COSMIC	PLTPVPS	DEG_SCF_FBW7_1	1031:1037	Mutation altering degron motif	0.6752
p.R521L	639-V	urinary tract	COSMIC	DSGHSST	DEG_SCF_TRCP1_1	512:518	Mutation rewiring degron network	0.25
p.A902T	RL	haematopoietic and lymphoid tissue	COSMIC	PSTPLHT	DEG_SCF_FBW7_1	908:914	Mutation rewiring degron network	0.1667
p.A902T	KNS-62	lung	COSMIC	PSTPLHT	DEG_SCF_FBW7_1	908:914	Mutation rewiring degron network	0.1667
p.P1195H	Mewo	skin	COSMIC	VATPPPS	DEG_SCF_FBW7_1	1180:1186	Mutation rewiring degron network	0.0833
p.D542N	U-266	haematopoietic and lymphoid tissue	COSMIC	ERQELDRLL	DEG_APCC_DBOX_1	537:545	Mutation altering degron motif	0.5821
p.E922K	KYSE-510	oesophagus	COSMIC	PSTPLHT	DEG_SCF_FBW7_1	908:914	Mutation rewiring degron network	0.1111
p.K1034T	HCC2998	large intestine	COSMIC	PLTPVPS	DEG_SCF_FBW7_1	1031:1037	Mutation altering degron motif	0.7306
p.M1039I	SW48	large intestine	COSMIC	PLTPVPS	DEG_SCF_FBW7_1	1031:1037	Mutation rewiring degron network	0.2778
p.R1023H	CW-2	large intestine	COSMIC	PLTPVPS	DEG_SCF_FBW7_1	1031:1037	Mutation rewiring degron network	0.1111
p.G1029W	ABC-1	lung	COSMIC	PLTPVPS	DEG_SCF_FBW7_1	1031:1037	Mutation rewiring degron network	0.2778
p.I1172N	BV-173	haematopoietic and lymphoid tissue	COSMIC	VATPPPS	DEG_SCF_FBW7_1	1180:1186	Mutation rewiring degron network	0.1111

Kaplan plot for TNS2 in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

TNS2

UniProt ID: Q63HR2

Entrez ID: 23371

Protein name: Tensin-2 (EC 3.1.3.48) (C1 domain-containing phosphatase and tensin homolog) (C1-TEN) (Tensin-like C1 domain-containing phosphatase)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for TNS2 in