DegronMD

Uniprot ID: Q63HR2

Source protein: Tensin-2

Source gene: TNS2

Class: DEG_SCF_FBW7_1

Location: 908:914

E3 ligase: FBXW7

DEGRON score: 0.9637

ASA_SCORE: 82.9857

COIL: 0.8899

CONS_SCORE: 0.4001

DSS_SCORE: 0.7657

HELIX: 0.019

FCONS_SCORE: 1.0847

RIG_SCORE: 0.5294

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.G905W	ABC-1	lung	COSMIC	PSTPLHT	DEG_SCF_FBW7_1	0.25
p.M915I	SW48	large_intestine	COSMIC	PSTPLHT	DEG_SCF_FBW7_1	0.75
p.A902T	RL	haematopoietic_and_lymphoid_tissue	COSMIC	PSTPLHT	DEG_SCF_FBW7_1	0.1667
p.A902T	KNS-62	lung	COSMIC	PSTPLHT	DEG_SCF_FBW7_1	0.1667
p.E922K	KYSE-510	oesophagus	COSMIC	PSTPLHT	DEG_SCF_FBW7_1	0.1111

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q63HR2	Tensin-2	DEG_SCF_FBW7_1	908:914	PSTPLHT	FBXW7	0.9637	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons