DegronMD

Uniprot ID: Q63HR2

Source protein: Tensin-2

Source gene: TNS2

Class: DEG_APCC_DBOX_1

Location: 537:545

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.944

ASA_SCORE: 74.9222

COIL: 0.1596

CONS_SCORE: 0.4012

DSS_SCORE: 0.6546

HELIX: 0.8372

FCONS_SCORE: 1.1072

RIG_SCORE: 0.7557

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.R540W	SIDM00781	Colorectal Carcinoma	GDSC	ERQELDRLL	DEG_APCC_DBOX_1	0.8634
p.R540W	SIDM00780	Colorectal Carcinoma	GDSC	ERQELDRLL	DEG_APCC_DBOX_1	0.8634
p.R540W	SIDM01451	Pancreatic Carcinoma	GDSC	ERQELDRLL	DEG_APCC_DBOX_1	0.8634
p.D552N	SIDM00417	Plasma Cell Myeloma	GDSC	ERQELDRLL	DEG_APCC_DBOX_1	0.5833
p.D552N	U-266	haematopoietic_and_lymphoid_tissue	COSMIC	ERQELDRLL	DEG_APCC_DBOX_1	0.5833
p.P538A	SIDM01424	B-Lymphoblastic Leukemia	GDSC	ERQELDRLL	DEG_APCC_DBOX_1	0.7503
p.G553E	RL95-2	endometrium	COSMIC	ERQELDRLL	DEG_APCC_DBOX_1	0.1111
p.D542N	U-266	haematopoietic_and_lymphoid_tissue	COSMIC	ERQELDRLL	DEG_APCC_DBOX_1	0.5821

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q63HR2	Tensin-2	DEG_APCC_DBOX_1	537:545	ERQELDRLL	APC,CDC20,FZR1	0.944	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons