DegronMD

Uniprot ID: Q63HR2

Source protein: Tensin-2

Source gene: TNS2

Class: DEG_SCF_FBW7_1

Location: 1180:1186

E3 ligase: FBXW7

DEGRON score: 0.9271

ASA_SCORE: 53.5714

COIL: 0.8093

CONS_SCORE: 0.4557

DSS_SCORE: 0.4033

HELIX: 0.0446

FCONS_SCORE: 1.1063

RIG_SCORE: 0.6798

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.R1174C	SNU-C2B	large_intestine	COSMIC	VATPPPS	DEG_SCF_FBW7_1	0.1667
p.E1188K	KYSE-520	oesophagus	COSMIC	VATPPPS	DEG_SCF_FBW7_1	0.2778
p.P1195H	Mewo	skin	COSMIC	VATPPPS	DEG_SCF_FBW7_1	0.0833
p.I1172N	BV-173	haematopoietic_and_lymphoid_tissue	COSMIC	VATPPPS	DEG_SCF_FBW7_1	0.1111

DegronMD: protein-targeted degradation, mutation and drug response to degrons