DegronMD - Q68CZ2(TNS3)

Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.A1025S	TCGA-05-4382	LUAD	TCGA	LAPPSSQAFLGF	DEG_ODPH_VHL_1	1011:1022	Mutation rewiring degron network	0.25
p.A1025S	DO24900	LUAD	ICGC	LAPPSSQAFLGF	DEG_ODPH_VHL_1	1011:1022	Mutation rewiring degron network	0.25
p.Q1221L	TCGA-17-Z031	LUAD	TCGA	VATPPPS	DEG_SCF_FBW7_1	1212:1218	Mutation rewiring degron network	0.25
p.A1213V	TCGA-69-7979	LUAD	TCGA	VATPPPS	DEG_SCF_FBW7_1	1212:1218	Mutation altering degron motif	0.5825
p.A1213V	DO23874	LUAD	ICGC	VATPPPS	DEG_SCF_FBW7_1	1212:1218	Mutation altering degron motif	0.5825
p.A1025T	TCGA-AA-3510	COAD	TCGA	LAPPSSQAFLGF	DEG_ODPH_VHL_1	1011:1022	Mutation rewiring degron network	0.25
p.A1025T	DO7783	COAD	ICGC	LAPPSSQAFLGF	DEG_ODPH_VHL_1	1011:1022	Mutation rewiring degron network	0.25
p.T402M	TCGA-AJ-A8CW	UCEC	TCGA	DSGHST	DEG_SCF_TRCP1_1	392:397	Mutation rewiring degron network	0.1944
p.T402M	DO48971	PBCA	ICGC	DSGHST	DEG_SCF_TRCP1_1	392:397	Mutation rewiring degron network	0.1944
p.T402M	DO52400	UCEC	ICGC	DSGHST	DEG_SCF_TRCP1_1	392:397	Mutation rewiring degron network	0.1944
p.V389I	TCGA-AZ-6601	COAD	TCGA	DSGHST	DEG_SCF_TRCP1_1	392:397	Mutation rewiring degron network	0.25
p.V389I	DO8119	COAD	ICGC	DSGHST	DEG_SCF_TRCP1_1	392:397	Mutation rewiring degron network	0.25
p.M1210I	TCGA-B5-A0JY	UCEC	TCGA	VATPPPS	DEG_SCF_FBW7_1	1212:1218	Mutation rewiring degron network	0.2778
p.M1210I	DO43041	UCEC	ICGC	VATPPPS	DEG_SCF_FBW7_1	1212:1218	Mutation rewiring degron network	0.2778
p.D1228G	TCGA-BA-6869	HNSC	TCGA	VATPPPS	DEG_SCF_FBW7_1	1212:1218	Mutation rewiring degron network	0.0556
p.D1228G	DO14250	HNSC	ICGC	VATPPPS	DEG_SCF_FBW7_1	1212:1218	Mutation rewiring degron network	0.0556
p.G1021S	TCGA-BR-A4J4	STAD	TCGA	LAPPSSQAFLGF	DEG_ODPH_VHL_1	1011:1022	Mutation altering degron motif	0.5882
p.G1021S	TCGA-D3-A8GI	SKCM	TCGA	LAPPSSQAFLGF	DEG_ODPH_VHL_1	1011:1022	Mutation altering degron motif	0.5882
p.G1021S	DO50284	SKCM	ICGC	LAPPSSQAFLGF	DEG_ODPH_VHL_1	1011:1022	Mutation altering degron motif	0.5882
p.G1021S	DO38671	STAD	ICGC	LAPPSSQAFLGF	DEG_ODPH_VHL_1	1011:1022	Mutation altering degron motif	0.5882
p.S1003F	TCGA-D3-A2JN	SKCM	TCGA	LAPPSSQAFLGF	DEG_ODPH_VHL_1	1011:1022	Mutation rewiring degron network	0.1111
p.S1003F	DO47590	SKCM	ICGC	LAPPSSQAFLGF	DEG_ODPH_VHL_1	1011:1022	Mutation rewiring degron network	0.1111
p.V1212G	TCGA-D3-A8GI	SKCM	TCGA	VATPPPS	DEG_SCF_FBW7_1	1212:1218	Mutation altering degron motif	0.7532
p.V1212G	DO50284	SKCM	ICGC	VATPPPS	DEG_SCF_FBW7_1	1212:1218	Mutation altering degron motif	0.7532
p.G1023S	TCGA-DM-A1D9	COAD	TCGA	LAPPSSQAFLGF	DEG_ODPH_VHL_1	1011:1022	Mutation rewiring degron network	0.3056
p.G1023S	DO8866	COAD	ICGC	LAPPSSQAFLGF	DEG_ODPH_VHL_1	1011:1022	Mutation rewiring degron network	0.3056
p.Q1017H	TCGA-ER-A19P	SKCM	TCGA	LAPPSSQAFLGF	DEG_ODPH_VHL_1	1011:1022	Mutation altering degron motif	0.647
p.Q1017H	DO47623	SKCM	ICGC	LAPPSSQAFLGF	DEG_ODPH_VHL_1	1011:1022	Mutation altering degron motif	0.647
p.G1227E	TCGA-IB-7651	PAAD	TCGA	VATPPPS	DEG_SCF_FBW7_1	1212:1218	Mutation rewiring degron network	0.0833
p.G1227E	DO46657	PAAD	ICGC	VATPPPS	DEG_SCF_FBW7_1	1212:1218	Mutation rewiring degron network	0.0833
p.L1011V	TCGA-P4-AAVM	KIRP	TCGA	LAPPSSQAFLGF	DEG_ODPH_VHL_1	1011:1022	Mutation altering degron motif	0.6765
p.L1011V	DO219695	KIRP	ICGC	LAPPSSQAFLGF	DEG_ODPH_VHL_1	1011:1022	Mutation altering degron motif	0.6765
p.A1205S	DO234457	ESAD	ICGC	VATPPPS	DEG_SCF_FBW7_1	1212:1218	Mutation rewiring degron network	0.1389
p.Q1221K	DO229018	LICA	ICGC	VATPPPS	DEG_SCF_FBW7_1	1212:1218	Mutation rewiring degron network	0.25
p.N1223K	DO229026	LICA	ICGC	VATPPPS	DEG_SCF_FBW7_1	1212:1218	Mutation rewiring degron network	0.1944
p.L1004Q	DO44740	LICA	ICGC	LAPPSSQAFLGF	DEG_ODPH_VHL_1	1011:1022	Mutation rewiring degron network	0.1389
p.F1019L	DO220858	MELA	ICGC	LAPPSSQAFLGF	DEG_ODPH_VHL_1	1011:1022	Mutation altering degron motif	0.587
p.K1224E	DO229264	THCA	ICGC	VATPPPS	DEG_SCF_FBW7_1	1212:1218	Mutation blocking ubiquitination signal	0.6111
p.P1216L	DO229221	THCA	ICGC	VATPPPS	DEG_SCF_FBW7_1	1212:1218	Mutation altering degron motif	0.6471
p.T386A	SIDM00933	Breast Carcinoma	GDSC	DSGHST	DEG_SCF_TRCP1_1	392:397	Mutation rewiring degron network	0.1667
p.T386A	ACH-000856	Breast Cancer	CCLE	DSGHST	DEG_SCF_TRCP1_1	392:397	Mutation rewiring degron network	0.1667
p.T386A	CAL-51	breast	COSMIC	DSGHST	DEG_SCF_TRCP1_1	392:397	Mutation rewiring degron network	0.1667
p.S1218L	SIDM00399	Head and Neck Carcinoma	GDSC	VATPPPS	DEG_SCF_FBW7_1	1212:1218	Mutation altering degron motif	0.8778
p.S1218L	ACH-001228		CCLE	VATPPPS	DEG_SCF_FBW7_1	1212:1218	Mutation altering degron motif	0.8778
p.S1218L	SCC90	upper aerodigestive tract	COSMIC	VATPPPS	DEG_SCF_FBW7_1	1212:1218	Mutation altering degron motif	0.8778
p.D1009E	SIDM00427	Ewing's Sarcoma	GDSC	LAPPSSQAFLGF	DEG_ODPH_VHL_1	1011:1022	Mutation rewiring degron network	0.2778
p.D1009E	ACH-000499	Bone Cancer	CCLE	LAPPSSQAFLGF	DEG_ODPH_VHL_1	1011:1022	Mutation rewiring degron network	0.2778
p.D1009E	ACH-002194	Bone Cancer	CCLE	LAPPSSQAFLGF	DEG_ODPH_VHL_1	1011:1022	Mutation rewiring degron network	0.2778
p.D1009E	RH-1	soft tissue	COSMIC	LAPPSSQAFLGF	DEG_ODPH_VHL_1	1011:1022	Mutation rewiring degron network	0.2778
p.D384E	SIDM01752	Pancreatic Carcinoma	GDSC	DSGHST	DEG_SCF_TRCP1_1	392:397	Mutation rewiring degron network	0.1111
p.D384E	ACH-000685	Pancreatic Cancer	CCLE	DSGHST	DEG_SCF_TRCP1_1	392:397	Mutation rewiring degron network	0.1111
p.V389A	ACH-000999	Colon/Colorectal Cancer	CCLE	DSGHST	DEG_SCF_TRCP1_1	392:397	Mutation rewiring degron network	0.25
p.V389A	SNU-1040	large intestine	COSMIC	DSGHST	DEG_SCF_TRCP1_1	392:397	Mutation rewiring degron network	0.25
p.L1031H	ACH-001959	Bile Duct Cancer	CCLE	LAPPSSQAFLGF	DEG_ODPH_VHL_1	1011:1022	Mutation rewiring degron network	0.0833

DegronMD: protein-targeted degradation, mutation and drug response to degrons

TNS3

UniProt ID: Q68CZ2

Entrez ID: 64759

Protein name: Tensin-3 (Tensin-like SH2 domain-containing protein 1) (Tumor endothelial marker 6)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for TNS3 in